DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment IRS1 and Irs1

DIOPT Version :9

Sequence 1:NP_005535.1 Gene:IRS1 / 3667 HGNCID:6125 Length:1242 Species:Homo sapiens
Sequence 2:NP_034700.2 Gene:Irs1 / 16367 MGIID:99454 Length:1231 Species:Mus musculus


Alignment Length:1245 Identity:1111/1245 - (89%)
Similarity:1146/1245 - (92%) Gaps:17/1245 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     1 MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIP 65
            |||||::||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIP 65

Human    66 LESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAALGAG 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||    .|
Mouse    66 LESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAHHDGA----GG 126

Human   131 GGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFV 195
            |.|||||||||:||||||||| |..||||||||||||||||||||||||||||||||||||||||
Mouse   127 GCGGSCSGSSGVGEAGEDLSY-DTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFV 190

Human   196 KLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAM 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   191 KLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAM 255

Human   261 SDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFR 325
            ||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   256 SDEFRPRSKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFR 320

Human   326 VRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSARLHPPLNHSRSIPMPASRCSPSATSPV 390
            |||||||||||||||||||||||||||||||||||||:|||||||||||||||:|||||||||||
Mouse   321 VRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPV 385

Human   391 SLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPP 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   386 SLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPP 450

Human   456 ARGEEELSNYICMGGKGPSTLTAPNGHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNR 520
            |||||||||||||||||.|||.||||||||||||||||..||..|||||||.|||||.|||||||
Mouse   451 ARGEEELSNYICMGGKGASTLAAPNGHYILSRGGNGHRYIPGANLGTSPALPGDEAAGAADLDNR 515

Human   521 FRKRTHSAGTSPTITHQKTPSQSSVASIEEYTEMMP-AYPPGGGSGGRLPGHRHSAFVPTRSYPE 584
            ||||||||||||||:||||||||||||||||||||| ||||||||||||||:||||||||.||||
Mouse   516 FRKRTHSAGTSPTISHQKTPSQSSVASIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPE 580

Human   585 EGLEMHPLERRGGHHRPDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINP 649
            ||||||.|||||||||||:|.|||||||||||||||||||.|||:||||||||||||||||||||
Mouse   581 EGLEMHHLERRGGHHRPDTSNLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINP 645

Human   650 IRRHPQRVDPNGYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHP 714
            ||||||||||||||||||||.|||||||| ||||||.:|.|||:||||.|||||||||:|.|||.
Mouse   646 IRRHPQRVDPNGYMMMSPSGSCSPDIGGG-SSSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHA 709

Human   715 KPPVESSGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGE 779
            ||||||.||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||
Mouse   710 KPPVESGGGKLLPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGE 774

Human   780 PEEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPHLPRK 844
            |||||||||||||:|||||.|.|||:|||||||||||||||||||.|.||.||||.|||||||||
Mouse   775 PEEGARHQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSLTHPHHHVLQPHLPRK 839

Human   845 VDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIEFGSDQSGYL 909
            |||||||||||||||||||||||||||||.||||||||..|||||||||||||||||||.|.|||
Mouse   840 VDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQSSLHPPEPKSPGEYVNIEFGSGQPGYL 904

Human   910 SGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGVEMGRLGPAPPGAAS 974
            :||....||||||||.||.|||| ||||:||||.|||||||||.||||.|||:||:||||||:|:
Mouse   905 AGPATSRSSPSVRCPPQLHPAPR-EETGSEEYMNMDLGPGRRATWQESGGVELGRIGPAPPGSAT 968

Human   975 ICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIAAEEVSLPRATMAAASSSSA 1039
            :|||||:||:|||||||||:.|||||||||||.|||||||||||||||:.||||.|.||...||.
Mouse   969 VCRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKASLPRPTGAAPPPSST 1033

Human  1040 ASASPTGPQGA-AELAAHSSLLGGPQGPGGMSAFTRVNLSPNRNQSAKVIRADPQGCRRRHSSET 1103
            ||:|.| |||| ||.|.|||||||||||||||||||||||||.||||||||||.|||||||||||
Mouse  1034 ASSSVT-PQGATAEQATHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAKVIRADTQGCRRRHSSET 1097

Human  1104 FSSTPSATRVGNTVPFGAGAAVGG-GGGSSSSSEDVKRHSSASFENVWLRPGELGGAPKEPAKLC 1167
            ||   :.||.|||||||||||||| |||....||||||||||||||||||||:|||..||.|.:|
Mouse  1098 FS---APTRAGNTVPFGAGAAVGGSGGGGGGGSEDVKRHSSASFENVWLRPGDLGGVSKESAPVC 1159

Human  1168 GAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQPPPPPPPHQPLGSGESSSTRRSSEDLSAYASI 1232
            |||||||..||||||||.|:..   |:|..:.|..|||||||||||.|.:|.||||||||.||||
Mouse  1160 GAAGGLEKSLNYIDLDLAKERS---QDCPSQQQSLPPPPPHQPLGSNEGNSPRRSSEDLSNYASI 1221

Human  1233 SFQKQPEDRQ 1242
            ||||||||||
Mouse  1222 SFQKQPEDRQ 1231

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IRS1NP_005535.1 Mediates interaction with PHIP. /evidence=ECO:0000250 3..137 124/133 (93%)
PH_IRS 11..118 CDD:269959 106/106 (100%)
PTB_IRS 160..263 CDD:269915 102/102 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..430 164/167 (98%)
YXXM motif 1 465..468 2/2 (100%)
YXXM motif 2 551..554 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 592..616 21/23 (91%)
YXXM motif 3 612..615 2/2 (100%)
YXXM motif 4 632..635 2/2 (100%)
YXXM motif 5 662..665 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 668..693 19/24 (79%)
YXXM motif 6 732..735 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 771..900 117/128 (91%)
GRB2-binding. /evidence=ECO:0000250 896..898 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 918..937 15/18 (83%)
YXXM motif 7 941..944 2/2 (100%)
YXXM motif 8 989..992 2/2 (100%)
YXXM motif 9 1012..1015 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1057..1146 76/89 (85%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1190..1242 36/51 (71%)
Irs1NP_034700.2 Mediates interaction with PHIP. /evidence=ECO:0000250 3..133 124/133 (93%)
PH_IRS 11..118 CDD:269959 106/106 (100%)
PH 17..110 CDD:278594 92/92 (100%)
PTB_IRS 155..258 CDD:269915 102/102 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..425 164/167 (98%)
YXXM motif 1 460..463 2/2 (100%)
YXXM motif 2 546..549 2/2 (100%)
YXXM motif 3 608..611 2/2 (100%)
YXXM motif 4 628..631 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 651..720 58/69 (84%)
YXXM motif 5 658..661 2/2 (100%)
YXXM motif 6 727..730 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 766..985 187/219 (85%)
GRB2-binding. /evidence=ECO:0000250 891..893 1/1 (100%)
YXXM motif 7 935..938 2/2 (100%)
YXXM motif 8 983..986 2/2 (100%)
YXXM motif 9 1006..1009 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1176..1231 38/57 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C83953737
Domainoid 1 1.000 1735 1.000 Domainoid score I471
eggNOG 1 0.900 - - E1_28N3R
HGNC 1 1.500 - -
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4049
Inparanoid 1 1.050 2231 1.000 Inparanoid score I1232
Isobase 00.000 Not matched by this tool.
NCBI 1 1.000 - -
OMA 1 1.010 - - QHG40234
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001178
OrthoInspector 1 1.000 - - oto120832
orthoMCL 1 0.900 - - OOG6_105771
Panther 1 1.100 - - LDO PTHR10614
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4611
SonicParanoid 1 1.000 - - X1499
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1717.290

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