DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment IRS1 and irs1

DIOPT Version :9

Sequence 1:NP_005535.1 Gene:IRS1 / 3667 HGNCID:6125 Length:1242 Species:Homo sapiens
Sequence 2:XP_002937134.1 Gene:irs1 / 100495320 XenbaseID:XB-GENE-478672 Length:1091 Species:Xenopus tropicalis


Alignment Length:1286 Identity:755/1286 - (58%)
Similarity:845/1286 - (65%) Gaps:247/1286 - (19%)


- Green bases have known domain annotations that are detailed below.


Human     1 MASPPE---SDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKR 62
            ||||.:   .:.||||||||||||||||||||||||:|||: |.||||||||||||||||.||||
 Frog     1 MASPTDPQAQENFSDVRKVGYLRKPKSMHKRFFVLRSASES-GLARLEYYENEKKWRHKSGAPKR 64

Human    63 SIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH-----HD 122
            ||||||||||||||||||||||||||::|.|||||:.|.|||.|||||:.||||.|.|     ||
 Frog    65 SIPLESCFNINKRADSKNKHLVALYTKEECFAIAAECEQEQDGWYQALVDLHNRGKTHHQHHNHD 129

Human   123 GAAALGAGGGGGSCSGSSGL--GEAGEDLSYGDV-PPGPAFKEVWQVILKPKGLGQTKNLIGIYR 184
            ||              ::|:  |..|:|: ||:| |||.|||||||||:|||||||.|||:||||
 Frog   130 GA--------------TNGVHDGLNGDDV-YGEVTPPGLAFKEVWQVIMKPKGLGQLKNLVGIYR 179

Human   185 LCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNM 249
            ||||::|||.|||||:||||||||||||||||||||||||||||||||.||||||||||||||||
 Frog   180 LCLTNRTISLVKLNSDAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGAGEFWMQVDDSVVAQNM 244

Human   250 HETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPA 314
            ||||||||:|:||||||||||||||||||||||||||||||:||||||||.||:||||:||||||
 Frog   245 HETILEAMKALSDEFRPRSKSQSSSNCSNPISVPLRRHHLNHPPPSQVGLNRRARTESVTATSPA 309

Human   315 SMVG--GKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSARLHPPLNHSRSIPM 377
            ..|.  |...|||||||||||||||||||::|||||||.:|..:||||||:||||||||||||||
 Frog   310 GGVAKHGSSSSFRVRASSDGEGTMSRPASMEGSPVSPSASRAQSHRHRGSSRLHPPLNHSRSIPM 374

Human   378 PASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSF 442
            ||:||||||||||||||||||||||||||:.||||||||||||||||||||||||||||||||||
 Frog   375 PATRCSPSATSPVSLSSSSTSGHGSTSDCMCPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSF 439

Human   443 RSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPNGHYILSRGGNGHRCTPGTGLGTSPALA 507
            ||||||||||||||| ||||:||||||..|.....:....|.||||                   
 Frog   440 RSVTPDSLGHTPPAR-EEELNNYICMGKSGSHLQRSQQQRYQLSRG------------------- 484

Human   508 GDEAASAADLDNRFRKRTHSAGTS-PTITHQKTPSQSSVASIEEYTEMMPAYPPGGGSGGRLPGH 571
                ....|.|..|||||||:||| ||::||||||||   |||||||||||:|.      ||...
 Frog   485 ----EEHPDFDKVFRKRTHSSGTSPPTVSHQKTPSQS---SIEEYTEMMPAHPV------RLTSF 536

Human   572 RHSAFVPTRSYPEEGLEMHPLERRGGHHRPDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMS 636
            ||||||||.|||||.|::| ||        .|...|||||||||||||||||:   .|.||||||
 Frog   537 RHSAFVPTYSYPEECLDLH-LE--------GSRANHTDDGYMPMSPGVAPVPT---KSNDYMPMS 589

Human   637 PKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTN 701
            ||||||||||||| ||| ..||.||||||||||.||||                 .|:|.|:|||
 Frog   590 PKSVSAPQQIINP-RRH-SAVDSNGYMMMSPSGSCSPD-----------------STNYSKIWTN 635

Human   702 GVGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYS 766
            |.         :||..::|..|| |||: ||:||||...|.||:|.|.|....:...|||.||:|
 Frog   636 GT---------NPKLSIDSIEGK-LPCS-DYINMSPASGSTTSTPPDSYLNSIEESTKPVYSYFS 689

Human   767 LPRSFKHTQRPGEPEEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPH 831
            |||||||..|  :.|:|    :||::.:||..||  |.|.||||||||||||             
 Frog   690 LPRSFKHVHR--KSEDG----NLRITANSGHNLY--TEDSSSSSTSSDSLGG------------- 733

Human   832 PHHQVLQPHLPRKVDTAAQTNSRLARPTRLSL-GDPKASTLPRAREQQQQQQPLLHPPEPKSPGE 895
                 ..|..|||.:|..| ..||.||||||| ...||||||||||      |.| |||||||||
 Frog   734 -----QDPQQPRKGETCIQ-GKRLTRPTRLSLENSSKASTLPRARE------PAL-PPEPKSPGE 785

Human   896 YVNIEFGSDQ--SGYLSGPVAFHSSPSVRCP---SQLQPAPREEETGTEEYMKMDLGPGRRAAWQ 955
            |||||| :|:  ||.|        .||: ||   .|.:..|:.|  ...|||.||||     .|:
 Frog   786 YVNIEF-NDKVFSGGL--------MPSM-CPLPFVQSRVVPQRE--NLSEYMNMDLG-----VWR 833

Human   956 EST---GVEMGRLGPAPPGAASICRPTRAVPSSR---------GDYMTMQMSCPRQSYVDTSP-- 1006
            ..|   ........|.....:|:| ||....|||         .|||:||:|.....|....|  
 Frog   834 AKTSYASTSSSSYEPPYKPVSSVC-PTETCSSSRPPIRGKTNSRDYMSMQLSALCSDYSQVPPTR 897

Human  1007 --AAPV-------SYADMRTGIAAEEV-SLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLG 1061
              |.|:       :||:|.:|..::.: ::|:     .|:||.:.||            .|||||
 Frog   898 ITAKPITLSSNKSNYAEMSSGGVSDNIPAIPQ-----TSNSSLSEAS------------RSSLLG 945

Human  1062 GPQGPGGMSAFTRVNLSPNRNQSAKVIRA-DPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAV 1125
            ...||   ||||||:|||||||||||||| |||| |||||||||||||:..||.:          
 Frog   946 QGSGP---SAFTRVSLSPNRNQSAKVIRAGDPQG-RRRHSSETFSSTPTTARVTS---------- 996

Human  1126 GGGGGSSSSSEDVKRHSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQ 1190
                 ...|.||||||||||||||||:|||:  |.::..:   .:....||||||||||.||...
 Frog   997 -----GPVSGEDVKRHSSASFENVWLKPGEI--ARRDSLQ---PSDHTHNGLNYIDLDLAKDLSG 1051

Human  1191 CPQECTPEPQPPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDR 1241
            . ..|.          .||       |.....|:|||.||||:|.|..|.|
 Frog  1052 L-DHCN----------SHQ-------SGVSHPSDDLSTYASITFHKLEEHR 1084

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IRS1NP_005535.1 Mediates interaction with PHIP. /evidence=ECO:0000250 3..137 101/141 (72%)
PH_IRS 11..118 CDD:269959 92/106 (87%)
PTB_IRS 160..263 CDD:269915 92/102 (90%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..430 146/169 (86%)
YXXM motif 1 465..468 2/2 (100%)
YXXM motif 2 551..554 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 592..616 11/23 (48%)
YXXM motif 3 612..615 2/2 (100%)
YXXM motif 4 632..635 2/2 (100%)
YXXM motif 5 662..665 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 668..693 6/24 (25%)
YXXM motif 6 732..735 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 771..900 65/129 (50%)
GRB2-binding. /evidence=ECO:0000250 896..898 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 918..937 7/21 (33%)
YXXM motif 7 941..944 2/2 (100%)
YXXM motif 8 989..992 2/2 (100%)
YXXM motif 9 1012..1015 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1057..1146 56/89 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1190..1242 16/52 (31%)
irs1XP_002937134.1 PH_IRS 14..120 CDD:269959 92/106 (87%)
PTB_IRS 155..258 CDD:269915 92/102 (90%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 835 1.000 Domainoid score I1081
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H4049
Inparanoid 1 1.050 1222 1.000 Inparanoid score I2176
NCBI 1 1.000 - -
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D154392at33208
OrthoFinder 1 1.000 - - FOG0001178
OrthoInspector 1 1.000 - - oto154171
Panther 1 1.100 - - LDO PTHR10614
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1499
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
99.160

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