DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADPS and Agps

DIOPT Version :9

Sequence 1:	NP_001188935.1	Gene:	ADPS / 36669	FlyBaseID:	FBgn0033983	Length:	631	Species:	Drosophila melanogaster
Sequence 2:	NP_445802.2	Gene:	Agps / 84114	RGDID:	620364	Length:	670	Species:	Rattus norvegicus

Alignment Length:	608	Identity:	320/608 - (52%)
Similarity:	417/608 - (68%)	Gaps:	21/608 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AVTTEAPESSAPGEGTALALDSRLSKRVESVIPKKRHEALKWFGWGYNDSQF-YGKDGIICFRGE 70
            |..:.|...:||..||               |||||.|.:||.|||||||:| ..|.|.:...|:
  Rat    79 AGASPAASPAAPESGT---------------IPKKRQELMKWNGWGYNDSKFLLNKKGQVELTGK 128

  Fly    71 KYPLGGCELPSFTKWVEKKFDLRVD--TTKQYPQLPRTYPRPVENAPFLHELKGTTQVDYSAEGI 133
            :|||.|..||:...|::....:.::  ||.:....|...|..:.|..||.||| ...:.||.:..
  Rat   129 RYPLSGLALPTLKDWIQNTLGVNLEHKTTSKPSINPSEAPPSIVNEDFLQELK-EAHISYSQDAD 192

  Fly   134 DRLVRCHGQTLNDIYSLWHHKFRRIPDLVVWPRCHDEVVQLVRLANKHNVMLVPFGGGTSVSGAI 198
            ||:.|.||..|::|:.|....|.||||:||||.|||:||::|.||.|:|:.::|.|||||||..:
  Rat   193 DRVFRAHGHCLHEIFLLREGMFERIPDIVVWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYGL 257

  Fly   199 TCPQNESRMICALDTSQMNRLLWLNRENLTVCFESGIVGQDLERVLRSEGLTVGHEPDSYEFSTL 263
            .||.:|:|.|.:||||||||:||::..|||...|:||.||||||.|:..|...||||||.|||.:
  Rat   258 MCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQDLERQLKESGYCTGHEPDSLEFSIV 322

  Fly   264 GGWVATRASGMKKNVYGNIEDLVVRVRMVTPSGTLERECSAPRVSCGPDFNHVILGSEGTLGVIT 328
            |||::|||||||||||||||||||.::||||.|.:|:....||:|.|||.:|.|:||||||||||
  Rat   323 GGWISTRASGMKKNVYGNIEDLVVHMKMVTPRGVIEKSSQGPRMSTGPDIHHFIMGSEGTLGVIT 387

  Fly   329 EVVLKVRPLPSLRRYGSLAFPNFEQGVLFMREVARRRCQPASVRLMDNEQFMFGQALKPE-KSWW 392
            |..:|:||.|..::|||:|||||||||..:||:|::||.|||:|||||:||.||.||||: .|.:
  Rat   388 EATIKIRPTPEYQKYGSVAFPNFEQGVACLREIAKQRCAPASIRLMDNQQFQFGHALKPQVSSIF 452

  Fly   393 ASVVDAMKQRYVTSWKGIDLNQICAATLLFEGDLKDVQRQEALIYEIAEKFQGFPAGGQNGERGY 457
            .|.:|..|:.|:|.:||.|.|||..||||||||.:.|.:.|..:|:||.||.|..||..||:|||
  Rat   453 TSFLDGFKKFYITKFKGFDPNQISVATLLFEGDREKVLQHEKQVYDIAAKFGGLAAGEDNGQRGY 517

  Fly   458 ILTFVIAYIRDFGLHQGIVAESFETSVPWDRCSLLCRSVKQRVVSECSKRSINYYTIS-CRVTQT 521
            :||:||||:||.||...:|.||||||.||||...|||:||:|:..||.:|.:.:..:| ||||||
  Rat   518 LLTYVIAYMRDLGLEYYVVGESFETSAPWDRVIDLCRNVKERIRRECKERGVQFAPLSTCRVTQT 582

  Fly   522 YDAGACIYFYFGFRSTDVADPVELFEAIEHSARDEILSCGGSLSHHHGVGKIRSHWYRNAVTETG 586
            |||||||||||.|....::||:.:||..|.:||||||:.||||||||||||:|..|.:.::::.|
  Rat   583 YDAGACIYFYFAFNYRGISDPLTVFEQTEAAARDEILANGGSLSHHHGVGKLRKQWLKESISDVG 647

  Fly   587 SSLYSAAKRHLDPKNIFALGNLL 609
            ..:..:.|.::||.|||...|||
  Rat   648 FGMLKSVKDYVDPSNIFGNRNLL 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADPS	NP_001188935.1	GlcD	152..612	CDD:223354	268/460 (58%)
		FAD_binding_4	159..300	CDD:279851	89/140 (64%)
		FAD-oxidase_C	337..608	CDD:280983	150/272 (55%)
Agps	NP_445802.2	GlcD	212..664	CDD:223354	263/451 (58%)
		FAD_binding_4	218..361	CDD:279851	90/142 (63%)
		FAD-oxidase_C	396..669	CDD:280983	150/272 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351076
Domainoid	1	1.000	319	1.000	Domainoid score	I1209
eggNOG	1	0.900	-	-		E1_COG0277
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2716
Inparanoid	1	1.050	653	1.000	Inparanoid score	I748
OMA	1	1.010	-	-		QHG60851
OrthoDB	1	1.010	-	-		D152982at33208
OrthoFinder	1	1.000	-	-		FOG0006627
OrthoInspector	1	1.000	-	-		oto98717
orthoMCL	1	0.900	-	-		OOG6_103310
Panther	1	1.100	-	-	LDO	PTHR46568
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4864
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810