Protein Alignment Kank and Kank3

DIOPT Version :10

• Sequence 1: NP_001097318.1
• Gene: Kank / 36668
• FlyBaseID: FBgn0027596
• Length: 1339
• Species: Drosophila melanogaster
• Sequence 2: XP_008763424.1
• Gene: Kank3 / 366848
• RGDID: 1308853
• Length: 818
• Species: Rattus norvegicus
• Alignment Length: 1294
• Identity: 287/1294 - (22%)
• Similarity: 434/1294 - (33%)
• Gaps: 534/1294 - (41%)

  Fly    67 SANPAPAGITRSVRSCNC--CPYGYHIDLDFVRYCEALALEKPSEEEQRRRDRRRSRKSMEFMLG 129
            |..|.|.|..||..|...  .|||:|:||||::|.         ||.:|....||:
  Rat    17 SLYPGPTGSARSPSSPYSVETPYGFHLDLDFLKYV---------EEIERGPASRRA--------- 63

  Fly   130 FESLFGGDWQAESRVQGKLSETSHESEPDSPHPIGGGGSLHMSQSYTTTPCYRPRSSSVPRFTYG 194
                                       |..||                  ..|||:|.     .|
  Rat    64 ---------------------------PGPPH------------------ARRPRASG-----KG 78

  Fly   195 SIPPRSESPFGTASSTCSSLRGGVES--DAGIYHQRHRPAISPPETRAF-LHEALDEVCSDFERT 256
            ....||...: |:|.:.:|..||...  ..|.:.....|.:||   |:| .:..::....:..|.
  Rat    79 LAGARSPGAW-TSSESLASDDGGASGALSPGAFPGLSLPPLSP---RSFSRNPRVEHTLLETSRR 139

  Fly   257 LERTSVKRRKSPYGAGSLSMDRNNNKLSLSISNGHGALKELKSHRLGNSTWDRHFDVADSCIGGN 321
            ||:...:.|                    ::|....|.:..:.                   .|.
  Rat   140 LEQAQAQER--------------------ALSPARAATRSPRG-------------------SGR 165

  Fly   322 QSPTGTPRPFLRSNTLPLRQRPSPAEVQYESYVQATVAANAKSPVEQLESAKSPGAPPPPPPRRH 386
            .||  .|.|.|.|.: |:...|.||::|.
  Rat   166 SSP--APNPALASPS-PVLASPGPAQLQL------------------------------------ 191

  Fly   387 HLLATTPTGKPTFKEDRPQENGSVSSSSLQSPVISETGQTTADAQALFQIREQMALSLRRLKDLE 451
                                                             :|||||::||||::||
  Rat   192 -------------------------------------------------VREQMAVALRRLRELE 207

  Fly   452 EQVKVIPDMELELNSLRSEKQKLLRRNEELMRSQRQTPSPPSPGLKTASPVQFTPQRISP----- 511
            :|.:.:|:::.::.:||:||.:||....:           |...::    ::..|.::|.
  Rat   208 DQARALPELQEQVRALRAEKARLLAGRVQ-----------PEQDVE----IEVRPDKLSQLRRLT 257

  Fly   512 --VSLESLGARMRSSSTSASPSPSVVRRDVSTQAVVRPPATRDVSVGHQPTTRNVGVQPSETVYS 574
              ::....|.|.|:|..:..|.....||......|: .||:|  :...:|.||..|.:
  Rat   258 ERLATSDRGVRSRASPRAEDPDGLAARRSEGALQVL-DPASR--TPDGEPQTREAGTE------- 312

  Fly   575 KEELDKKVEQALTNAQKQQLRKLISVGTQMYVPQRDQKDSGVQTTPERPKLKYHVGVTVKPATRE 639
                                                                      |.|.|||
  Rat   313 ----------------------------------------------------------VVPETRE 319

  Fly   640 NFTSCKPDVRHVGSSDDRLDDVLCEKCAVSKRSVACGPETPAEKVKPAPQMPGRSNTFSLGENET 704
            ......|:.|..|
  Rat   320 VDAQAVPETREAG---------------------------------------------------- 332

  Fly   705 VSVVRKTIGCQTPVT---LVLSSGSQTTTAVVRSTGAQVNPQQQHSGVQCATEQVSRQTDTKGLQ 766
            |.||.:|:...|.||   |.|...::....::|::       .:|.               :|:.
  Rat   333 VEVVPETVEVDTWVTEALLGLPEAAERELELLRTS-------LEHQ---------------RGVS 375

  Fly   767 RLTRSQTKAEQVSESVPRPTTRHTASNTDKVEEAEPAKVRTSHSACNTEEVRKRDVGCGDIVKPH 831
            .|.|.:.:                     ::|||..|.|..|.|         |:|
  Rat   376 ELLRGRLR---------------------ELEEAHEAIVTRSQS---------REV--------- 401

  Fly   832 ISIACAANYCDSCKEAIQDLARGFSKASPTATRTG-GAVRRSTSADSRIPRPKHLSSPSPVRKEF 895
                                          ||:|. |...::|..:            .||..:
  Rat   402 ------------------------------ATQTTLGYTEKTTQTE------------LPVESQ- 423

  Fly   896 MRQNTYTLATPSPTPSPQVERKARLSSLQEKPPSVSSFQASEPLPESQSFIRQPQKDSLDLSLLG 960
                      |.||...::.....|.|:.:|.......|:|:. |:|..|:.         .|.|
  Rat   424 ----------PRPTAGDEMAPAGILKSIMKKKDGTPGAQSSQG-PKSLQFVG---------VLNG 468

  Fly   961 EDELIVREEKRVSISWSRDASPAPLMTSSGTTKSESPEQEPAMSSSSDSSPPIDVQIAQGARKKS 1025
            |.|....|:...|.. ..|.:..|..:|||              |..|||...|          :
  Rat   469 EYESSSSEDASNSDD-EDDVAELPRSSSSG--------------SGDDSSGGSD----------A 508

  Fly  1026 STPLKSSQSEGSQVTVIEQPATKAQLHQLAQADSEPRKKT------ELSQSLKDALKIINDSLLK 1084
            .||...:          :|.|...:|      :..|.:||      ||:..|::|...:|..|::
  Rat   509 GTPGPHN----------DQDAGDCEL------EMHPEQKTGREGRCELNPRLREACIALNQQLMR 557

  Fly  1085 KLGA------KPISSQSLKSAKATIQDHWFTNSSTGKSDPHQVEDYLDYFESLSIPLLEYCVNLS 1143
            ..|.      .|..|.|.::|...:...||..||..:.....|...|...:||...||.:.|||:
  Rat   558 PRGVTSRDALMPTLSWSCQNAARLVAQEWFRVSSQKRCQAEPVAGVLRGVKSLGPELLAHVVNLA 622

  Fly  1144 DSNGNTAMHYAVSHGNFDVVSILLDSKVCDVNQMNNAGYTSVMLVSLAKL-KQPAHRTVVERLFK 1207
            |.|||||:||:|||||..:.|:|||:.|||||..|.|||:::||.:|..: |:.....||:|||.
  Rat   623 DGNGNTALHYSVSHGNLAISSLLLDTGVCDVNHQNRAGYSALMLAALTSVGKEEEDMAVVQRLFS 687

  Fly  1208 MADVNIRAKKHCQTALMLAVSHGNGDMVNMLLDAGADINIQDEDGSTALMCAAEHGRVDVIKHLL 1272
            |.|||.:|.:..|||||||:|||:.|||..||:.|||:|:||.||:||||||:|:||:|.::.||
  Rat   688 MGDVNAKASQTGQTALMLAISHGHQDMVAALLECGADVNVQDADGATALMCASEYGRLDTVQLLL 752

  Fly  1273 SHPECDSLVTDVDGSTAFKIAWQAGHRDVGLLIYVHEQMLRSKLPNRGDATRSSLISPP 1331
            :.|.||..:.|.:|::|..||.:|...:|..|::.|   |.|   |..|:...|....|
  Rat   753 AQPGCDLTILDNEGTSALAIALEAEQDEVAALLHAH---LTS---NHHDSQEQSTPGSP 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kank	NP_001097318.1	KN_motif	76..>102	CDD:432311	12/27 (44%)
		ANKYR	1066..1305	CDD:440430	109/245 (44%)
		ANK repeat	1146..1215	CDD:293786	38/69 (55%)
		ANK repeat	1217..1249	CDD:293786	19/31 (61%)
Kank3	XP_008763424.1	KN_motif	32..73	CDD:432311	18/103 (17%)
		COG4913	<129..>322	CDD:443941	60/402 (15%)
		ANKYR	<614..802	CDD:440430	97/193 (50%)
		ANK repeat	625..657	CDD:293786	21/31 (68%)
		ANK repeat	659..695	CDD:293786	16/35 (46%)
		ANK repeat	697..729	CDD:293786	19/31 (61%)
		ANK repeat	731..763	CDD:293786	17/31 (55%)