Protein Alignment Kank and Kank1

DIOPT Version :10

• Sequence 1: NP_001097318.1
• Gene: Kank / 36668
• FlyBaseID: FBgn0027596
• Length: 1339
• Species: Drosophila melanogaster
• Sequence 2: NP_001032274.2
• Gene: Kank1 / 309429
• RGDID: 1307714
• Length: 1360
• Species: Rattus norvegicus
• Alignment Length: 1522
• Identity: 364/1522 - (23%)
• Similarity: 576/1522 - (37%)
• Gaps: 474/1522 - (31%)

  Fly    86 PYGYHIDLDFVRYCEALALEKPSEEEQRRRDRRRSRKSMEFMLGFESLFG--GDWQAESRVQGKL 148
            |||:.:|||||:|.:.:......::...::.|:.|....|    ..::.|  |.|.:..    .|
  Rat    36 PYGFQLDLDFVKYVDDIQKGNTIKKLNIQKRRKPSGPCAE----VRAIPGPQGVWTSTE----SL 92

  Fly   149 SETSHESEPDSPHPIGGGGSLHMSQSYTTTPCYRPRSSSVPRFTYGSIPPRSESPFGTASSTCSS 213
            |.::.:.....|       |..:::|:.|       |:.:||      ||   :|..|:.:...|
  Rat    93 SSSNSDDSKQCP-------SFLLARSHVT-------STPIPR------PP---APLETSPTFAIS 134

  Fly   214 LRGGVESDAGIYHQRHRPAISPPETRAFLHEA-LDEVCSDFERTLERTSVKRRKSPYGAGSLSMD 277
                          .:|..:.||..:...|.. :.:...:..|.||:..|..:.:|   |.....
  Rat   135 --------------ENRQLLPPPSPQLPRHNLHVTKTLMETRRRLEQERVTMQMAP---GEFRRP 182

  Fly   278 RNNNKLSLSISNGHGALKELKSHRLGNSTWDRHFDVADSCIGGNQSPTGTPRPFLRSNTLPLRQR 342
            |      |:...|.|:...|.|. :|:               ||           .|:.:...|.
  Rat   183 R------LASFGGMGSTSSLPSF-MGS---------------GN-----------HSSAMHQLQN 214

  Fly   343 PSPAEVQYESYVQATVAANAKSPVEQLESAKSPGAPPPPPPRRHHLLATTPTGKPTFKEDRPQEN 407
            .......|.|||.|.                                       ||        .
  Rat   215 GYQGNGDYSSYVPAV---------------------------------------PT--------T 232

  Fly   408 GSVSSSSLQSPVIS--ETGQTTADAQALFQIREQMALSLRRLKDLEEQVKVIPDMELELNSLRSE 470
            .|:.||...||:.|  .|..|......|..||||||::|:|||:|||||:.||.::::::.|:.|
  Rat   233 SSMGSSVRHSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELEEQVRTIPVLQVKISVLQEE 297

  Fly   471 KQKLLRRNEELMRSQRQTPSPPSPGLKTAS--------------------------------PVQ 503
            |::|..:    :::||......:.|::..|                                .|:
  Rat   298 KRQLASQ----LKNQRAASQNEACGVRKRSYSAGNASQLELLSRARRGGGELYIDYEEEEMESVE 358

  Fly   504 FTPQRIS-----PVSLESLGARMRSSSTSASP----SPSVVRRDVSTQAVVRPP----------- 548
            .:.|||.     ...:::|..:::.||..|:|    :.....|:..:.||....
  Rat   359 QSTQRIREFRQLTADMQALEQKIQDSSCEATPELRENGQCASRERKSVAVGSDENMNDIVVYHRD 423

  Fly   549 --ATRDVSVGHQPTTRNVGVQPSETVYSK-EELDKKVE--QALTNAQKQQLRKLISVGTQMYVPQ 608
              :.:|.:||....|||.|:..:|.:... .|.||::|  |....|.|:::.:|   ..|:....
  Rat   424 FRSRKDTAVGTVTETRNFGISVTEAMLGVITEADKEIELQQQTIEALKEKIYRL---EVQLKETT 485

  Fly   609 RDQK-----------------DSGVQTTPERPKLKYHVGVTVKPATRENFTSCKPDVRHVGSSDD 656
            .||:                 |..:...|    |.:...|.....|||..         |||..|
  Rat   486 HDQEMTKLKQELQAAGSRKKVDKAIMAQP----LVFSKLVEALVPTREQM---------VGSHVD 537

  Fly   657 RLDDVLCEKCAVSKRSVACGPETPAEKVKPAPQMP-------GRSNTFSLGENETVSVVRKTIGC 714
            .:|..:......|....:|.|:...:.|  .|::|       .|..|.......:|....:::|.
  Rat   538 TMDSCVGTSVQTSSVGTSCHPDRKNQVV--GPELPMNWWVVKERVGTHDRCVGRSVETCNRSVGV 600

  Fly   715 QTPV----TLVLSSGSQTTTAV-------VRSTGAQVNPQQQHSGVQCATEQV--------SRQT 760
            :..|    :...:|||..|...       |||.|..          .|:.:.:        ||..
  Rat   601 EVSVCETGSNTEASGSDLTLLKTNLNLKDVRSIGCG----------DCSVDVIVCLPKECTSRSM 655

  Fly   761 DTKGLQRLTRSQTKAEQVSESVPRPTTRHTASNTDKVEEAEPAKVRTSHSAC------------- 812
            :|:.:       .:.|....:||..|.:||::|.::|::....:|.|...:|
  Rat   656 NTEAV-------GQGEAAVMAVPHTTDQHTSTNLERVDQGTNTEVTTLVESCTNTLLSTLDKQTS 713

  Fly   813 --NTE-------EVRKRDV----------------GCGDIVKPHISIACAA-------------- 838
              |.|       |.|.||:                |..|..||     ||.
  Rat   714 TQNVEMRTVAIGEGRVRDINPSTKTRSVGVGTVLSGSSDFDKP-----CAVKTKESGVGQINIHD 773

  Fly   839 NYCDSCKEAIQDLARGFSKASPTATRTG--GAVRRS-------------------------TSAD 876
            ||....|  ::.:|.|     |.....|  |: |||                         |..|
  Rat   774 NYLVGLK--MRTIACG-----PPQLTVGLIGS-RRSVGVGNEPVGDLLEDPLQPQVPSGMMTGLD 830

  Fly   877 SRIPRPKHLSSPSPVRKEFMRQNTYTLATPSPTPSPQV-----ERKARLSSLQEKPPSVS----- 931
            ..|.|.:.|.:.   ::..:.:|...||.....|..|:     :..:.|||:.....|.|
  Rat   831 HYIERVQKLLAE---QQTLLAENYSELAEAFGEPHSQIGSLNSQLISTLSSINSVMKSASTEELR 892

  Fly   932 --------------------------------SFQASEPLPESQS---------FIRQPQKDSLD 955
                                            :.|.|:|..|:::         |:  .|.::|.
  Rat   893 NPDFQKSSLGKIAGNHLECTCKCGGLRSGGLVNVQTSQPEVETETTEGKRGCEQFL--TQGNTLP 955

  Fly   956 LSLLGEDELIV-------REEKRVSISWSRDASPAPLMTSSG---------------TTKSESPE 998
            ...|.:|::..       .|....||....|.:    ..|:|               ||.|:...
  Rat   956 PVNLTDDQIATGLYVCPNNENTLKSIMKKSDGN----KDSNGAKKNLQFIGVNGGYETTSSDDSS 1016

  Fly   999 QEPAMSSSSDSS------PPIDVQIAQGARKKSSTPLKSSQSEGSQVTVIE--QPA---TKAQLH 1052
            ...:.||.||..      ||.:.:..:...:...|   ...:||.....||  |.|   .:.|:.
  Rat  1017 SGGSSSSESDDECDTNGYPPEEEEEEEEEEEDHDT---RGMAEGRHAVNIEGFQSARVEDEVQVP 1078

  Fly  1053 QLAQADSEPRKKTELSQSLKDALKI----INDSLLKKLGAKPISSQSLKSAKATIQDHWFTNSST 1113
            :......|.|::.|||:.:..|..:    |||       .|.::|:.::....|:|..||..||.
  Rat  1079 ECEPEKEEIRERYELSEKMLSACSLLKYNIND-------PKALASKDMRICLNTLQHEWFRVSSQ 1136

  Fly  1114 GKSDPHQVEDYLDYFESLSIPLLEYCVNLSDSNGNTAMHYAVSHGNFDVVSILLDSKVCDVNQMN 1178
            ..:.|..|.||:..||::|..:|.|.:|::|.|||||:||:|||.||.:|.:|||:.||:|:..|
  Rat  1137 KSAVPAMVGDYIAAFEAVSPDVLRYIINMADGNGNTALHYSVSHSNFQIVKLLLDADVCNVDHQN 1201

  Fly  1179 NAGYTSVMLVSLAKLKQPAHRTVVERLFKMADVNIRAKKHCQTALMLAVSHGNGDMVNMLLDAGA 1243
            .||||.:||.:||.::......|||.||...|||.:|.:..|||||||||||..|||..||..||
  Rat  1202 KAGYTPIMLAALAAVEAEKDMQVVEELFSCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGA 1266

  Fly  1244 DINIQDEDGSTALMCAAEHGRVDVIKHLLSHPECDSLVTDVDGSTAFKIAWQAGHRDVGLLIYVH 1308
            |:||||::||||||||:|||.|:::|.||:.|.|...:.|.|||||..||.:|||:|:.:|:|.|
  Rat  1267 DVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCSGHLEDNDGSTALSIALEAGHKDIAVLLYAH 1331

  Fly  1309 EQMLRSKLPNRGDATRSSLISP-PRHK 1334
            ....:::.|:.....|.:  || |.|:
  Rat  1332 LNFSKAQSPSTPRLGRKT--SPGPTHR 1356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kank	NP_001097318.1	KN_motif	76..>102	CDD:432311	9/15 (60%)
		ANKYR	1066..1305	CDD:440430	115/242 (48%)
		ANK repeat	1146..1215	CDD:293786	36/68 (53%)
		ANK repeat	1217..1249	CDD:293786	21/31 (68%)
Kank1	NP_001032274.2	KN_motif	30..68	CDD:432311	9/31 (29%)
		YhaN	269..>501	CDD:443752	50/238 (21%)
		ANKYR	<1148..1337	CDD:440430	99/188 (53%)
		ANK repeat	1169..1201	CDD:293786	19/31 (61%)
		ANK repeat	1242..1272	CDD:293786	21/29 (72%)
		ANK repeat	1274..1306	CDD:293786	17/31 (55%)