Protein Alignment Kank and KANK3

DIOPT Version :10

• Sequence 1: NP_001097318.1
• Gene: Kank / 36668
• FlyBaseID: FBgn0027596
• Length: 1339
• Species: Drosophila melanogaster
• Sequence 2: XP_016882052.1
• Gene: KANK3 / 256949
• HGNCID: 24796
• Length: 872
• Species: Homo sapiens
• Alignment Length: 1281
• Identity: 293/1281 - (22%)
• Similarity: 420/1281 - (32%)
• Gaps: 520/1281 - (40%)

  Fly    70 PAP-AGITRSVRSCNC--CPYGYHIDLDFVRYCEALALEKPSEEEQRRRDRRRSRKSMEFMLGFE 131
            |.| ||..||..|...  .|||:|:||||::|.|.|.....:.........||.|.....:.|..
Human    71 PVPAAGGARSPSSPYSVETPYGFHLDLDFLKYIEELERGPAARRAPGPPTSRRPRAPRPGLAGAR 135

  Fly   132 SLFGGDWQAESRVQGKLSETSHESEPDSPHPIGGGGSLHMSQSYTTTPCYRPRSSSVPRFTYGSI 196
            |  .|.|            ||.||....    .||....:||...:....:|.|
Human   136 S--PGAW------------TSSESLASD----DGGAPGILSQGAPSGLLMQPLS----------- 171

  Fly   197 PPRSESPFGTASSTCSSLRGGVESDAGIYHQRHRPAISPPETRAFLHEALDEVCSDFERTLERTS 261
             ||:                              |..:|                ..|.||..||
Human   172 -PRA------------------------------PVRNP----------------RVEHTLRETS 189

  Fly   262 VKRRKSPYGAGSLSMDRNNNKLSLSISNGHGALKELKSHRLGNSTWDRHFDVADSCIGGNQSPTG 326
              ||                   |.::..|
Human   190 --RR-------------------LELAQTH----------------------------------- 198

  Fly   327 TPRPFLRSNTLPLRQRPSPAEVQYESYVQATVAANAKSPVEQLESAKSPGAPPPPPPRRHHLLAT 391
                                                       |.|.|||...|..||
Human   199 -------------------------------------------ERAPSPGRGVPRSPR------- 213

  Fly   392 TPTGKPTFKEDRPQENGSVSSSSLQSPVISETGQTTADAQALFQIREQMALSLRRLKDLEEQVKV 456
                            ||..||  .:|.::......|..|.   :|||||.:||||::||:|.:.
Human   214 ----------------GSGRSS--PAPNLAPASPGPAQLQL---VREQMAAALRRLRELEDQART 257

  Fly   457 IPDMELELNSLRSEKQKLLRRNEELMRSQRQTPSPPSPGLKTASPVQFTPQR--ISPVSLESLGA 519
            :|:::.::.:||:||.:||        :.|..|.|  .|.....|.:....|  ...::....|.
Human   258 LPELQEQVRALRAEKARLL--------AGRAQPEP--DGEAETRPDKLAQLRRLTERLATSERGG 312

  Fly   520 RMRSSSTSASPSPSVVRRDVSTQAVVRPPATRDVSVGHQPTTRNVGVQPSETVYSKEELDKKVEQ 584
            |.|:|..:.||......|......|:      |..||                    .||
Human   313 RARASPRADSPDGLAAGRSEGALQVL------DGEVG--------------------SLD----- 346

  Fly   585 ALTNAQKQQLRKLISVGTQMYVPQRDQKDSGVQTTPERPKLKYHVGVTVKPATRENFTSCKPDVR 649
                            ||                                |.|||
Human   347 ----------------GT--------------------------------PQTRE---------- 353

  Fly   650 HVGSSDDRLDDVLCEKCAVSKRSVACGPETPAEKVKPAPQMPGRSNTFSLGENETVSVVRKTIGC 714
                              |:..:|   |||
Human   354 ------------------VAAEAV---PET----------------------------------- 362

  Fly   715 QTPVTLVLSSGSQTTTAVVRSTGAQVNPQQQHSGVQCATEQVSRQTDTKGLQRLTRSQTKAEQVS 779
                               |..|||..|:.:.:||:.|.|.|  :.|....:.|......||:
Human   363 -------------------REAGAQAVPETREAGVEAAPETV--EADAWVTEALLGLPAAAER-- 404

  Fly   780 ESVPRPTTRHTASNTDKVEEAEPAKVRTSHSACNTEEVRKRDVGCGDIVKPHISIACAANYCDSC 844
                               |.|..:....|....:|.:|.|                 ....:..
Human   405 -------------------ELELLRASLEHQRGVSELLRGR-----------------LRELEEA 433

  Fly   845 KEAIQDLARGFSKASPTATRTGGAVRRSTSADSRIPRPKHLSSPSPVRKEFMRQNTYTLA----- 904
            :||.::.|.| ::|.         :|.:|:                       |..::.|
Human   434 REAAEEAAAG-ARAQ---------LREATT-----------------------QTPWSCAEKAAQ 465

  Fly   905 TPSPTPSPQVERKARLSSLQEKPPSVSSFQASEPLPESQSFIR--------QPQKDSLDLSLLGE 961
            |.||..:|.:.:       :..|.|:...:|..|....:|.::        ||......|..:|
Human   466 TESPAEAPSLTQ-------ESSPGSMDGDRAVAPAGILKSIMKKRDGTPGAQPSSGPKSLQFVG- 522

  Fly   962 DELIVREEKRVSISWSRDASPAPLMTSSGTTKSESPEQEPAMSSSSDSSPPIDVQIAQGARKKSS 1026
               ::..|  ...|.|.|||     .|.|.:::...|...:.|.|.|.|         |....|.
Human   523 ---VLNGE--YESSSSEDAS-----DSDGDSENGGAEPPGSSSGSGDDS---------GGGSDSG 568

  Fly  1027 TPLKSSQSEGSQVTVIEQPATKAQLHQLAQADSEPRKKTELSQSLKDALKIINDSLLKKLGAKPI 1091
            ||   ....|..:...| |..:|:..|:||.      :.|||..|::|...:...|     ::|.
Human   569 TP---GPPSGGDIRDPE-PEAEAEPQQVAQG------RCELSPRLREACVALQRQL-----SRPR 618

  Fly  1092 SSQSLKSAKATIQDHWFTNSSTGKSDPHQVEDYLDYFESLSIPLLEYCVNLSDSNGNTAMHYAVS 1156
            ...|...|...:...||..||..:|....|...|:....|...||.:.|||:|.|||||:||:||
Human   619 GVASDGGAVRLVAQEWFRVSSQRRSQAEPVARMLEGVRRLGPELLAHVVNLADGNGNTALHYSVS 683

  Fly  1157 HGNFDVVSILLDSKVCDVNQMNNAGYTSVMLVSLAKLKQPAH-RTVVERLFKMADVNIRAKKHCQ 1220
            |||..:.|:|||:..|:||:.|.|||:::||.:|..::|... ..||:|||.|.|||.:|.:..|
Human   684 HGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQ 748

  Fly  1221 TALMLAVSHGNGDMVNMLLDAGADINIQDEDGSTALMCAAEHGRVDVIKHLLSHPECDSLVTDVD 1285
            ||||||:|||..|||..||..|||:|.||.||:||||||:|:||:|.::.||:.|.||..:.|.:
Human   749 TALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNE 813

  Fly  1286 GSTAFKIAWQAGHRDVGLLIYVHEQMLRSKLPNRGDATRSSLISPP 1331
            |::|..||.:|...:|..|::.|   |.|..|:    |:|.  |||
Human   814 GTSALAIALEAEQDEVAALLHAH---LSSGQPD----TQSE--SPP 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kank	NP_001097318.1	KN_motif	76..>102	CDD:432311	13/27 (48%)
		ANKYR	1066..1305	CDD:440430	105/239 (44%)
		ANK repeat	1146..1215	CDD:293786	36/69 (52%)
		ANK repeat	1217..1249	CDD:293786	19/31 (61%)
KANK3	XP_016882052.1	KN_motif	84..125	CDD:432311	13/40 (33%)
		PksD	<109..637	CDD:442550	171/1019 (17%)
		ANKYR	<648..837	CDD:440430	93/191 (49%)
		ANK repeat	673..743	CDD:293786	36/69 (52%)
		ANK repeat	746..777	CDD:293786	19/30 (63%)
		ANK repeat	779..811	CDD:293786	17/31 (55%)