Protein Alignment Kank and Kank4

DIOPT Version :10

• Sequence 1: NP_001097318.1
• Gene: Kank / 36668
• FlyBaseID: FBgn0027596
• Length: 1339
• Species: Drosophila melanogaster
• Sequence 2: XP_011238824.1
• Gene: Kank4 / 242553
• MGIID: 3043381
• Length: 1023
• Species: Mus musculus
• Alignment Length: 1146
• Identity: 277/1146 - (24%)
• Similarity: 439/1146 - (38%)
• Gaps: 250/1146 - (21%)

  Fly   266 KSPYGAGSLSMDRNNNKLSLSISNGHGALKELKSHRLGN----STWDRHFDVADSCIGG------ 320
            ::|||   ..:|.:..|....|..|| .:|.:..||...    ||..|:|.:.:|  |.
Mouse    28 ETPYG---FHLDLDFLKYVDDIEKGH-TIKRIPIHRRAKQAKFSTLPRNFSLPNS--GDRTYAVP 86

  Fly   321 ---NQSPT-------GTPRPFLRSNTLPLRQRPSP----AEVQYESYVQATVAANAKSPVEQLES 371
               |.||.       ||..|   |..|||...|..    :|:.|  :.:|.:|.:|:.  .:..|
Mouse    87 PQQNWSPVVPRKISLGTQEP---SQPLPLGDLPQASVQGSELNY--HRKALLAKDARQ--AEAGS 144

  Fly   372 AKSPGAPPPPPPRRHHLLATTPTGKPTFKEDRPQENGSVS--SSSLQSPVISETGQTTAD----- 429
            .:..|:..|...|...:.||      ..:...|:|....|  |:.|..|::.:.| :..|
Mouse   145 LEDVGSGRPQLLRASSMPAT------LLQNQVPEEPSLTSGPSTLLALPLLQDEG-SVCDGAFDP 202

  Fly   430 AQALFQIREQMALSLRRLKDLEEQV--KVIPDMELELNSLRSEKQKLLRRNEELMRSQRQTPSPP 492
            |:.|...:.......|.|.:||..:  :|....|.|...|::....                |.|
Mouse   203 AEGLMGFQASAQSVDRELGELEPAIPEQVWEGAEPEEGDLKASSHL----------------SQP 251

  Fly   493 SPGLKTASPVQFTPQRISPVSLESLGARMRSSST-----SASPSP-----SVVRRDVSTQAV--- 544
            .|    :|.||..|..:..|.:|.   .||.:..     ||:|||     .::..|:|...:
Mouse   252 GP----SSAVQSVPMDLEEVEIEH---HMREAELVLTPGSATPSPPPLPSPILENDLSLDEIELS 309

  Fly   545 ---VRPPATRDV---SVGHQPTTRNVGVQPSET----------VYSKEELDKKVEQ------AL- 586
               :.||...:|   |:|.:.|..::|:..::|          :..:::|..:.|:      ||
Mouse   310 ISEIPPPPPIEVDVRSIGIRVTEESLGLLETDTSSISSLKNQVLALEDKLSGRTEELARVRAALE 374

  Fly   587 -----TNAQKQQLRKLISVGTQMYVPQRDQKDSGVQTT--PERPKLKYHVGVTVKPATRENFTSC 644
                 |.|::|::::|     :..|...::|.|..:.:  |:|      ...||.....:..|..
Mouse   375 QQEEETKAREQRIQEL-----ECTVAHLEEKLSQERASEAPDR------TDATVNTDPLQELTPR 428

  Fly   645 KPDVRHVGSSDDRLDDVLCEKCAVSKRSVACGP--ETPAEKVKPAPQMPGRSNTFSLGENETVSV 707
            :...:::|.:.....|..|......|...   |  :...::..|:|:.|......||.......:
Mouse   429 ESHDKNIGVNLLNTPDPECRAPRAEKNGF---PWVQNNHKQSYPSPEEPVLPPQLSLPRGPEQIL 490

  Fly   708 VRKTIGCQTPVTLVLSSGSQTTTAVVRSTGAQVNPQQQHSGVQCATEQVSRQTDTKGLQRLTRSQ 772
            ......|.:....:...||:           |...|::.:|               ||.|.....
Mouse   491 ASSLCSCLSMELRIEEEGSE-----------QEGGQEEGAG---------------GLSRAAGES 529

  Fly   773 TKAEQVSESVPRPTTRHTASNTDKVEEAE-PAKVRTSHSACNTEEVRKRDVGCGDIVKP-----H 831
            :.:.:.|    .|..|..|  |.::..|| |.:..:|          .:|...|..||.     |
Mouse   530 SWSTRES----APVIREEA--TSELPGAERPGRPASS----------PQDATIGQYVKKIQELLH 578

  Fly   832 ISIACAANYCDSCKEAIQDLARGFSKASPTATRTGGAVRRSTSADSRIPRPKHLSSPSPVRKEFM 896
            ....|..:.......||:..|...|........:...:..:.||.:..|.||...:|.|
Mouse   579 EQWNCLEHGYPELASAIKQPASKLSSIQNQLLSSLNLLLSAYSAQAPEPEPKETPAPPP------ 637

  Fly   897 RQNTYTLATPSPTPSPQVERKARLSSLQEKPPSVSSFQASEPLPESQSFIRQPQKDSLDLSLLGE 961
                 :...|.|.|.|::.....|.|:.:|..  ..|:|..         ...:|:...:.:.|.
Mouse   638 -----STPPPPPPPPPEISPSTSLKSIMKKKD--YGFRAGG---------NGTKKNLQFVGVNGG 686

  Fly   962 DELIVREEKRVSISWSRDASPAPLMTSSGTTKSESPEQEPAMSSSSDSSPPIDV--QIAQGARKK 1024
            .|....||     :...|:||..|..|....|.:..|..    ...|..|..:.  .:.:|.|..
Mouse   687 YETTSSEE-----TSGEDSSPEDLSDSETEKKQDCSESR----EDRDLHPSCEAGQGVPEGTRNS 742

  Fly  1025 SSTPLKSSQSEGSQVTVIEQPATKAQLHQLAQADSEPRKKTELSQSLKDALKIINDSLLKKLGAK 1089
            ..|     ...|.:|:           |..|:......:.....|:|...|....|:
Mouse   743 GHT-----SDRGEEVS-----------HLRAERYKPSEEFLNACQTLSQHLPETGDT-------- 783

  Fly  1090 PISSQSLKSAKATIQDHWFTNSSTGKSDPHQVEDYLDYFESLSIPLLEYCVNLSDSNGNTAMHYA 1154
              :.|.|:.:..||...||..||...|.|..|..||...:..|..||:..|||:|.:||||:||:
Mouse   784 --TKQLLRQSLNTISQEWFRVSSRKLSSPEAVAAYLLEVQPHSPYLLKLLVNLADRSGNTALHYS 846

  Fly  1155 VSHGNFDVVSILLDSK-------VCDVNQMNNAGYTSVMLVSLAKLKQPAHRTVVERLFKMADVN 1212
            |||.||.:|.:|||:.       ||:|:..|.||||:||:..||..:......||.:|.:..:||
Mouse   847 VSHSNFAIVKLLLDTAPIPSFVGVCNVDHQNKAGYTAVMITPLASAETKEDMAVVWKLLREGNVN 911

  Fly  1213 IRAKKHCQTALMLAVSHGNGDMVNMLLDAGADINIQDEDGSTALMCAAEHGRVDVIKHLLSHPEC 1277
            |:|.:..||||||.|||...|||..||...||:|:||.|||:|||.|...|..|:::.||:||.|
Mouse   912 IQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDNDGSSALMLACHQGNADLVRLLLAHPAC 976

  Fly  1278 DSLVTDVDGSTAFKIAWQA-GHRDVGLLIYVHEQMLRSKLP 1317
            :|.:||..|.||..:...: .|.::..|:..|.:..||..|
Mouse   977 NSSLTDKAGRTALSLVLNSPAHVEIAELLRAHSEPGRSLGP 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kank	NP_001097318.1	KN_motif	76..>102	CDD:432311
		ANKYR	1066..1305	CDD:440430	98/246 (40%)
		ANK repeat	1146..1215	CDD:293786	33/75 (44%)
		ANK repeat	1217..1249	CDD:293786	17/31 (55%)
Kank4	XP_011238824.1	KN_motif	24..62	CDD:432311	11/37 (30%)
		hsdR	347..>409	CDD:236912	11/66 (17%)
		ANKYR	<827..1008	CDD:440430	81/180 (45%)
		ANK repeat	838..877	CDD:293786	18/38 (47%)
		ANK repeat	917..948	CDD:293786	17/30 (57%)
		ANK repeat	950..975	CDD:293786	12/24 (50%)