DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kank and KANK1

DIOPT Version :9

Sequence 1:	NP_001097318.1	Gene:	Kank / 36668	FlyBaseID:	FBgn0027596	Length:	1339	Species:	Drosophila melanogaster
Sequence 2:	NP_001243805.1	Gene:	KANK1 / 23189	HGNCID:	19309	Length:	1352	Species:	Homo sapiens

Alignment Length:	1541	Identity:	367/1541 - (23%)
Similarity:	569/1541 - (36%)	Gaps:	520/1541 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 PYGYHIDLDFVRYCEAL----ALEKPSEEEQRRRD----RRRSRKSMEFMLGFESLFGGDWQAES 142
            ||||.:||||::|.:.:    .:::.:.:::|:..    ..|:....:          |.|.:..
Human    36 PYGYQLDLDFLKYVDDIQKGNTIKRLNIQKRRKPSVPCPEPRTTSGQQ----------GIWTSTE 90

  Fly   143 RVQGKLSETSHESEPDSPHPIGGGGSLHMSQSYTTTPCYRPRSSSVPRFTYGSIPPRSES--PFG 205
                .||.::.:.....|:      .|......|:||..:|             ||..|:  ||.
Human    91 ----SLSSSNSDDNKQCPN------FLIARSQVTSTPISKP-------------PPPLETSLPFL 132

  Fly   206 TASSTCSSLRGGVESDAGIYHQRHRPAISPPETRAFLHEALDEVCSDFERTLERTSVKRRKSPYG 270
            |                 |...|..|..||...:..||  :.:...:..|.||:.....:.:|
Human   133 T-----------------IPENRQLPPPSPQLPKHNLH--VTKTLMETRRRLEQERATMQMTP-- 176

  Fly   271 AGSLSMDRNNNKLSLSISNGHGALKELKSHRLGNSTWDRHFDVADSCIGGNQSPTGTPRPFLRSN 335
             |.....|      |:...|.|....|.|. :|:               ||.:|.        .:
Human   177 -GEFRRPR------LASFGGMGTTSSLPSF-VGS---------------GNHNPA--------KH 210

  Fly   336 TLPLRQRPSPAEVQYESYVQATVAANAKSPVEQLESAKSPGAPPPPPPRRHHLLATTPTGKPTFK 400
            .|   |........|.||                    :|.||            ||
Human   211 QL---QNGYQGNGDYGSY--------------------APAAP------------TT-------- 232

  Fly   401 EDRPQENGSVSSSSLQSPVIS--ETGQTTADAQALFQIREQMALSLRRLKDLEEQVKVIPDMELE 463
                   .|:.||...||:.|  .|..|......|..||||||::|:|||:|||||:.||.::::
Human   233 -------SSMGSSIRHSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELEEQVRTIPVLQVK 290

  Fly   464 LNSLRSEKQKLLRRNEELMRSQRQTPSPPSPGLKTAS---------------------------- 500
            ::.|:.||::|:.:    :::||........|::..|
Human   291 ISVLQEEKRQLVSQ----LKNQRAASQINVCGVRKRSYSAGNASQLEQLSRARRSGGELYIDYEE 351

  Fly   501 ----PVQFTPQRIS-----PVSLESLGARMRSSSTSASP---------SPSVVRRDVSTQAVVRP 547
                .|:.:.|||.     ...:::|..:::.||..||.         |.:|...:.....||..
Human   352 EEMETVEQSTQRIKEFRQLTADMQALEQKIQDSSCEASSELRENGECRSVAVGAEENMNDIVVYH 416

  Fly   548 PATR---DVSVGHQPTTRNVGVQPSETVYS-KEELDKKVEQALTNAQKQQLRKLISVGTQMYVPQ 608
            ..:|   |.:||.....||.||..:|.:.. ..|.||::|     .|:|.:..|.....::.|..
Human   417 RGSRSCKDAAVGTLVEMRNCGVSVTEAMLGVMTEADKEIE-----LQQQTIESLKEKIYRLEVQL 476

  Fly   609 RDQKDSGVQTTPER--PKLKYHVGVTVKPATRENFTSCKPDV-------------RHVGSSDDRL 658
            |       :||.:|  .|||..:.........:..|..:|.|             :.|||..|.:
Human   477 R-------ETTHDREMTKLKQELQAAGSRKKVDKATMAQPLVFSKVVEAVVQTRDQMVGSHMDLV 534

  Fly   659 DDVLCEKCAVSKRSVAC---------GPETP------AEKVKPAPQMPGRSNTFSLGENETVSVV 708
            |..:......:...::|         |||.|      .|:|:...:..|||          |.:.
Human   535 DTCVGTSVETNSVGISCQPECKNKVVGPELPMNWWIVKERVEMHDRCAGRS----------VEMC 589

  Fly   709 RKTIGCQTPVTLVLSSGSQTTTAV--------------VRSTG--------AQVNPQQQHSGVQC 751
            .|::..:..   |..:||.|..:|              |||.|        ...:|:      :|
Human   590 DKSVSVEVS---VCETGSNTEESVNDLTLLKTNLNLKEVRSIGCGDCSVDVTVCSPK------EC 645

  Fly   752 ATEQVSRQTDTKGLQRLTRSQTKAEQVSESVPRPTTRHTASNTDKVEEAEPAKVRTSHSAC-NT- 814
            |:..|:           |.:.::.|....:|||...:.|:::.::|.:....:..|...:| ||
Human   646 ASRGVN-----------TEAVSQVEAAVMAVPRTADQDTSTDLEQVHQFTNTETATLIESCTNTC 699

  Fly   815 -----------------------------EEVRKRDVGCGDIVKPHISIACAANYCDSCKEAIQD 850
                                         ...:.|.:|.|.::..|
Human   700 LSTLDKQTSTQTVETRTVAVGEGRVKDINSSTKTRSIGVGTLLSGH------------------- 745

  Fly   851 LARGFSKASPTATRTGG-------------------------------AVRRSTSADSRIPRPKH 884
              .||.:.|...|:..|                               |.|||...... |..:.
Human   746 --SGFDRPSAVKTKESGVGQININDNYLVGLKMRTIACGPPQLTVGLTASRRSVGVGDD-PVGES 807

  Fly   885 LSSPSP----------------VRKEFMRQNTYTLATPSPTPSPQVERKARLSSLQEKPPSVSSF 933
            |.:|.|                ::|....|.|......|.......|..:::.||..:..|..|.
Human   808 LENPQPQAPLGMMTGLDHYIERIQKLLAEQQTLLAENYSELAEAFGEPHSQMGSLNSQLISTLSS 872

  Fly   934 QASEPLPESQSFIRQP--QKDSLDL---SLLGEDELIVREEKRVSISWSRDASPAPLMTSSGTTK 993
            ..|.....|...:|.|  ||.||..   :.||           .:.......|.:||     :::
Human   873 INSVMKSASTEELRNPDFQKTSLGKITGNYLG-----------YTCKCGGLQSGSPL-----SSQ 921

  Fly   994 SESPEQEPAMS-----SSSDSSP-------PI---DVQIA------------------------- 1018
            :..||||...|     ||.|:.|       |:   |.|||
Human   922 TSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACTNNESTLKSIMKKKDGNKD 986

  Fly  1019 -QGARKK-----------------SSTPLKSSQSEGSQVTVIEQPATK------------AQLH- 1052
             .||:|.                 ||:...||.....:..|||.|..:            |:.|
Human   987 SNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHH 1051

  Fly  1053 --------------QLAQADSEP-----RKKTELSQSLKDALKI----INDSLLKKLGAKPISSQ 1094
                          ::...:.||     |::.|||:.:..|..:    |||       .|.::|:
Human  1052 AVNIEGLKSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTIND-------PKALTSK 1109

  Fly  1095 SLKSAKATIQDHWFTNSSTGKSDPHQVEDYLDYFESLSIPLLEYCVNLSDSNGNTAMHYAVSHGN 1159
            .::....|:|..||..||...:.|..|.||:..||::|..:|.|.:||:|.|||||:||:|||.|
Human  1110 DMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSN 1174

  Fly  1160 FDVVSILLDSKVCDVNQMNNAGYTSVMLVSLAKLKQPAHRTVVERLFKMADVNIRAKKHCQTALM 1224
            |::|.:|||:.||:|:..|.||||.:||.:||.::......:||.||...|||.:|.:..|||||
Human  1175 FEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALM 1239

  Fly  1225 LAVSHGNGDMVNMLLDAGADINIQDEDGSTALMCAAEHGRVDVIKHLLSHPECDSLVTDVDGSTA 1289
            ||||||..|||..||..|||:||||::||||||||:|||.|:::|.||:.|.|:..:.|.|||||
Human  1240 LAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTA 1304

  Fly  1290 FKIAWQAGHRDVGLLIYVHEQMLRSKLPNRGDATRSSLISP-PRHK 1334
            ..||.:|||:|:.:|:|.|....:::.|......|.:  || |.|:
Human  1305 LSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRKT--SPGPTHR 1348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kank	NP_001097318.1	KN_motif	76..>102	CDD:288894	9/15 (60%)
		ANK	1141..1272	CDD:238125	75/130 (58%)
		ANK repeat	1146..1215	CDD:293786	35/68 (51%)
		Ank_4	1147..1239	CDD:290365	49/91 (54%)
		ANK repeat	1217..1249	CDD:293786	21/31 (68%)
		Ank_4	1221..1272	CDD:290365	35/50 (70%)
		Ank_4	1252..1301	CDD:290365	28/48 (58%)
KANK1	NP_001243805.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		KN_motif	30..68	CDD:314884	9/31 (29%)
		Nuclear export signal 1 (NES 1)	43..52		4/8 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..103		6/53 (11%)
		Nuclear localization signal 1 (NLS 1)	65..68		0/2 (0%)
		Nuclear export signal 2 (NES 2)	125..134		4/25 (16%)
		SMC_N	<264..>528	CDD:330553	64/279 (23%)
		Interaction with KIF21A. /evidence=ECO:0000269\|PubMed:19559006	291..467		37/184 (20%)
		Nuclear export signal 3 (NES 3)	613..622		0/8 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	914..951		12/41 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	979..1026		7/46 (15%)
		Nuclear localization signal 2 (NLS 2)	979..992		2/12 (17%)
		ANK 0, degenerate. /evidence=ECO:0000269\|PubMed:29183992	1109..1146		12/36 (33%)
		Interaction with KIF21A. /evidence=ECO:0000269\|PubMed:19559006	1156..1308		85/151 (56%)
		ANK	1156..1287	CDD:238125	75/130 (58%)
		ANK repeat	1161..1193	CDD:293786	19/31 (61%)
		ANK repeat	1234..1264	CDD:293786	21/29 (72%)
		ANK	1261..>1320	CDD:238125	33/58 (57%)
		ANK repeat	1266..1298	CDD:293786	17/31 (55%)
		ANK 5. /evidence=ECO:0000255	1300..1329		14/28 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1331..1352		6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141470
Domainoid	1	1.000	104	1.000	Domainoid score	I6716
eggNOG	1	0.900	-	-		E2759_KOG0514
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2629
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60237at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40678
orthoMCL	1	0.900	-	-		OOG6_109508
Panther	1	1.100	-	-	O	PTHR24168
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5057
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.760