DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kank and kank2

DIOPT Version :9

Sequence 1:	NP_001097318.1	Gene:	Kank / 36668	FlyBaseID:	FBgn0027596	Length:	1339	Species:	Drosophila melanogaster
Sequence 2:	XP_017948040.1	Gene:	kank2 / 100495496	XenbaseID:	XB-GENE-997067	Length:	887	Species:	Xenopus tropicalis

Alignment Length:	1337	Identity:	305/1337 - (22%)
Similarity:	452/1337 - (33%)	Gaps:	505/1337 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VLRSQRAFIEENARPIASSANPAPAGITRSVRSCNCCPYGYHIDLDFVRYCEALALEKPSEEEQR 113
            ||..:..|..:...|..||.....|..  ||.:    ||||.:||||::|.:  .:|| ....:|
Frog     5 VLHMEAHFPGKPGPPSLSSMKDPEAAY--SVET----PYGYRLDLDFLKYVD--DIEK-GHTIKR 60

  Fly   114 RRDRRRSRKSMEFMLGFESL-----FGGDWQAESRVQGKLSETSHESEPDSPHPIGGGGSLHMSQ 173
            ....||.|        :.||     :.|.|...:  :...|..|::|.             |.|.
Frog    61 VPVHRRPR--------YGSLPRGPGYTGSWWTST--ESLCSNASNDSR-------------HSSY 102

  Fly   174 SYTTTPCYRPRSSSVPRFTYGSIPPRSESPFGTASSTCSSLRGGVESDAGIYHQRHRPAISPPET 238
            ||.....|                |..||            |||.::.
Frog   103 SYCGRGFY----------------PAYES------------RGGAQAP----------------- 122

  Fly   239 RAFLHEALDEVCSDFERTLERTSVKRRKSPYGAGSLSMDRNNNKLSLSISNGHGALKELKSHRLG 303
                        .:|...:|:|.:                             .|.|:|::
Frog   123 ------------HNFNPRVEKTLL-----------------------------DASKKLEA---- 142

  Fly   304 NSTWDRHFDVADSCIGGNQSPTGTPRPF---LRS----NTLPLRQRPSPAEVQYESYVQATVAAN 361
                                  |..||.   .||    :|..|.:.||.:..|..|:
Frog   143 ----------------------GQSRPLSLGCRSTSSLSTQSLSRFPSTSSQQISSF-------- 177

  Fly   362 AKSPVEQLESAKSPGAPPPPPPRRHHLLATTPTGKPTFKEDRPQENGSVSSSSLQSPVISETGQT 426
                                          ||.                 ||.:.:||.....|
Frog   178 ------------------------------TPL-----------------SSGMSTPVSPSPAQ- 194

  Fly   427 TADAQALFQIREQMALSLRRLKDLEEQVKVIPDMELELNSLRSEKQKLLRRNEELMRSQRQTPSP 491
                  |..:|||||::|:||:.||||||:||.::::::.|:.||::
Frog   195 ------LQHVREQMAVALKRLRQLEEQVKMIPVLQVKISVLQEEKRQ------------------ 235

  Fly   492 PSPGLKTASPVQFTPQRISPVSLESLGARMRSSSTSASPSPSVVRRDVSTQAVVRPPATRDVSVG 556
                                     |..:::|......|..::..:|.....:..|
Frog   236 -------------------------LSVQLKSQKYLGHPRGNIRGKDRGELYIEIP--------- 266

  Fly   557 HQPTTRNVGVQPSETVYSKEELDKKVEQALTNAQKQQLRKLISVGTQMYVPQRDQKDSGVQTTPE 621
                       ..|:...|||.:.||      |.|:.             |:::.|
Frog   267 -----------EEESKVEKEEGEDKV------AGKEG-------------PEKENK--------- 292

  Fly   622 RPKLKYHVGVTVKPATRENFTSCKPDVRHVGSSDDRLDDVLCEKCAVSKRSVACGPETPAEKVKP 686
                                   ||:      .:.:....:|:|..|...|
Frog   293 -----------------------KPE------GEIKNPKEVCKKETVENNS-------------- 314

  Fly   687 APQMPGRSNTFSLGENETVSV-VRKTIGCQTPVTLVLSSGSQTTTAVVRSTGAQVNPQQQHSGVQ 750
               :||:...       :|.| ||:|.....|:                   .|:...:|...||
Frog   315 ---LPGKRMC-------SVGVWVRETDFAPLPI-------------------RQLEADKQKMLVQ 350

  Fly   751 CATEQVSRQTDTKGLQRLTRSQTKAEQVSESVPRPTTRHTASNTDKVEEAEPAKVRTSHSACNTE 815
            ..:.:::  ...|.|.|.......|.:..|...|......|:..:|.||.....|:.:.....:|
Frog   351 ALSAKIA--VLEKQLGRALIEVQNANRKLEEAERAGRAEEAAKREKKEEVRADAVKVARVERGSE 413

  Fly   816 EVRKRDVGCGDIVKPHISIACAANYCDSCKEAIQDLA-RGFSKASPTATRTGGAVRRSTSADSRI 879
            .|....||.|  |:|               :..:||. ||.:||      |.|...|...:...:
Frog   414 VVSSTKVGHG--VQP---------------QRARDLEWRGAAKA------TDGEEERVYKSKEVV 455

  Fly   880 PRPKHLSSPSPVRKEFMRQNTYTLATPSPTPSPQVE--------RKARLSSLQEKPPSVSSFQA- 935
            .:|  |.|||....:|......::.....|..|..|        :.|..|.:     :||...|
Frog   456 EKP--LLSPSGPAPKFHLVKKISITGHCSTEEPATEGNTGGILAQTATWSQM-----NVSGAAAG 513

  Fly   936 -----SEPLPESQSFIRQPQKDSLDLSLLGEDELIVREEKRVSISWSRDASPAPLMTSSGTTKSE 995
                 ::|..|.....|..|:|.                         ...||.....:|...|.
Frog   514 REGDGTDPTKEQDKGKRNAQEDP-------------------------QPKPAQFPRLNGEMDSA 553

  Fly   996 SPEQEPAMSSSSDSSPPIDVQIAQGARKKSSTPLKSSQSEGSQVTVIEQPATKAQLHQLAQADSE 1060
            |.|....|.:.|||               .||  :|...|.|:...    ..:|:||.||..:|:
Frog   554 SSEDSGTMENPSDS---------------EST--ESEYHEASEALA----GAQAELHSLAAGNSD 597

  Fly  1061 PRKKTELSQSLKDAL----------KIIN------DSLLKKLG---AKPISSQSLKSAKATIQDH 1106
            ..|:.|..|....|:          ::.|      .:|.|.|.   |.|...:|  :|.:.|...
Frog   598 TPKEPEREQPAPTAIVSPPKPTPRVELSNVLISGCVALQKSLDEGTALPEMEKS--AAHSVILQE 660

  Fly  1107 WFTNSSTGKSDPHQVEDYLDYFESLSIPLLEYCVNLSDSNGNTAMHYAVSHGNFDVVSILLDSKV 1171
            |.........||..:..:|..|.::|..|||..:|::|:.||||:|||||..||..|..|||:.:
Frog   661 WMKILRQKDVDPAVIRHHLTVFRAMSPRLLEVIINMADAKGNTAVHYAVSQSNFTAVRQLLDTGL 725

  Fly  1172 CDVNQMNNAGYTSVMLVSLAKLKQPAHRTVVERLFKMADVNIRAKKHCQTALMLAVSHGNGDMVN 1236
            ||||:.|.||:|.:||.:||..:.......|.::.::.|||.||.:..|||||||||||..|:|.
Frog   726 CDVNRQNKAGFTPLMLTALAAFRSDEDIETVTQMLRLGDVNCRASQAGQTALMLAVSHGRLDVVR 790

  Fly  1237 MLLDAGADINIQDEDGSTALMCAAEHGRVDVIKHLLSHPECDSLVTDVDGSTAFKIAWQAGHRDV 1301
            .||..|||:||||.|||||||||.|||..|::..||:.|.||..:||.|||||..||.:||..|:
Frog   791 ALLACGADVNIQDHDGSTALMCACEHGHADIVSLLLAVPACDVSLTDNDGSTALSIALEAGQNDI 855

  Fly  1302 GLLIYVHEQMLRSKLPNRGDATRSSLISPPRHKRQPS 1338
            .:|:..|    .||:.|:.:.|     .|.|.:..||
Frog   856 AMLLSAH----NSKISNQDEGT-----DPKRQRVNPS 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kank	NP_001097318.1	KN_motif	76..>102	CDD:288894	11/25 (44%)
		ANK	1141..1272	CDD:238125	70/130 (54%)
		ANK repeat	1146..1215	CDD:293786	31/68 (46%)
		Ank_4	1147..1239	CDD:290365	46/91 (51%)
		ANK repeat	1217..1249	CDD:293786	20/31 (65%)
		Ank_4	1221..1272	CDD:290365	34/50 (68%)
		Ank_4	1252..1301	CDD:290365	28/48 (58%)
kank2	XP_017948040.1	KN_motif	30..68	CDD:371886	16/46 (35%)
		TolA	<337..>457	CDD:225606	31/163 (19%)
		PRK13108	<484..620	CDD:237284	37/186 (20%)
		ANKYR	<688..840	CDD:223738	80/151 (53%)
		ANK repeat	700..732	CDD:293786	19/31 (61%)
		ANK repeat	735..769	CDD:293786	10/33 (30%)
		ANK repeat	773..803	CDD:293786	20/29 (69%)
		Ank_2	777..870	CDD:372319	54/96 (56%)
		ANK repeat	805..837	CDD:293786	18/31 (58%)
		ANK repeat	839..870	CDD:293786	15/34 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2327
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60237at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47857
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.060