DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kank and Kank2

DIOPT Version :9

Sequence 1:	NP_001097318.1	Gene:	Kank / 36668	FlyBaseID:	FBgn0027596	Length:	1339	Species:	Drosophila melanogaster
Sequence 2:	XP_006242651.1	Gene:	Kank2 / 100361376	RGDID:	2320289	Length:	847	Species:	Rattus norvegicus

Alignment Length:	1244	Identity:	293/1244 - (23%)
Similarity:	423/1244 - (34%)	Gaps:	481/1244 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 PYGYHIDLDFVRYCEALALEKPSEEEQRRRDRRRSRKSMEFMLGFESLFGGDWQAESRVQGKLSE 150
            ||||.:||||::|.:  .:|| ....:|...:||.|      ||......|.|.
  Rat    37 PYGYRLDLDFLKYVD--DIEK-GHTLRRVPVQRRPR------LGSLPRGPGSWW----------- 81

  Fly   151 TSHESEPDSPHPIGGGGSLHMSQSYTTTPCYRPRSSSVPRFTYGSIPPRSESPFGTASSTCSSLR 215
            ||.||....    ..|.|.|.:.||    |.|
  Rat    82 TSTESLCSD----ASGDSRHSAYSY----CGR--------------------------------- 105

  Fly   216 GGVESDAGIYHQRHRPAISPPETRAFLHEALDEVCSDFERTLERTSVKRRKSPYGAGSLSMDRNN 280
                   |.|     |.....|||:..:..::....|..|.||..:.  ..|..|.|||:.....
  Rat   106 -------GFY-----PQYGALETRSGTNPRVERTLLDARRRLEDQAA--APSSGGLGSLTPSAAG 156

  Fly   281 NKLSLSISNGHGALKELKSHRLGNSTWDRHFDVADSCIGGNQSPTGTPRPFLRSNTLPLRQRPSP 345
            :..||:   |.|.|
  Rat   157 STSSLA---GVGLL--------------------------------------------------- 167

  Fly   346 AEVQYESYVQATVAANAKSPVEQLESAKSPGAPPPPPPRRHHLLATTPTGKPTFKEDRPQENGSV 410
                                              ||.||
  Rat   168 ----------------------------------PPTPR-------------------------- 172

  Fly   411 SSSSLQSPVISETGQTTADAQALFQIREQMALSLRRLKDLEEQVKVIPDMELELNSLRSEKQKLL 475
             ||.|.:||....|.       |..:|||||.:||:|:.||||||:||.::::|:.|:.||::|.
  Rat   173 -SSGLSTPVAPSAGH-------LAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLT 229

  Fly   476 RRNEELMRSQRQTPSPPSPGLKTASPVQFTPQRISPVSLESLGARMRS----SSTSASPSPSVVR 536
            .:    ::||:....|.                         |.|.||    ....|...|:|:.
  Rat   230 VQ----LKSQKFLGHPS-------------------------GTRSRSELCLDLPEAPDDPAVLE 265

  Fly   537 RDVSTQAVVRPPATRDVSVGHQPTTRNVGVQPSET-----VYSKEELDKKVEQALTNAQKQQLRK 596
                         ||  |||.....|::|:...|.     |...|...||..|.|..||.||
  Rat   266 -------------TR--SVGTWVRERDLGIPDGEAALVAKVAVLETQLKKALQELRAAQTQQ--- 312

  Fly   597 LISVGTQMYVPQRDQKDSGVQTTPERPKLKYHVGVTVKPATRENFTSCKPDVRHVGSSDDRLDDV 661
             :.:..|.:.|...|.........|.|:
  Rat   313 -VDLQPQAWPPPDTQVRVDTVRVVEGPR------------------------------------- 339

  Fly   662 LCEKCAVSKRSVACGPETPAEKVKPAPQMPGRSNTFSLGENETVSVVRKTIGCQTPVTLVLSSGS 726
               :..|:..:.|..|...|:.::|          :..|                   |...:.|
  Rat   340 ---EVEVAASTAAGAPAQRAQSLEP----------YGAG-------------------LKALATS 372

  Fly   727 QTTTAVVRSTGAQVNPQQQHSGVQCATEQVSRQTDTKGLQRLTRSQTKAEQVSESVPRPTTRHTA 791
            ...|.|.||          |                             |.|....|.||
  Rat   373 AENTLVFRS----------H-----------------------------EVVETMCPLPT----- 393

  Fly   792 SNTDKVEEAEPAKVRTSHSACNTEEVRKRDVGCGDIVKPHISIACAANYCDSCKEAIQDLARGFS 856
                       |.....|:|                                            .
  Rat   394 -----------ASTSNMHTA--------------------------------------------K 403

  Fly   857 KASPTATRTGGAVRRSTSADSRIPRPKHLSSPSPVRKEFMRQNTYTLATP-SPTPSPQVERKARL 920
            |.|.|.....||.|   .||.    |...:.|||       .:.|..|.| :|.|:.|......|
  Rat   404 KISITERNCTGAAR---MADP----PPSPAEPSP-------SSPYPAAEPENPAPAAQDTTDREL 454

  Fly   921 SSLQEKPPSVSSFQASEPLPES----QSFIRQPQKDSLDLSLLGEDELIVREEKRVSISWSRDAS 981
            :    :|.:....||:|....:    ||.:::.:       :..:.::..|..:.|.|:...::|
  Rat   455 T----RPVASQDSQAAEGAGGASLGVQSALKRKE-------VPADPDVHQRNLQFVGINGGYESS 508

  Fly   982 PAPLMTSSG----TTKSESPEQEPAMSSSSDSSPPIDV-QIAQGARKKSSTPL--KSSQSEGSQV 1039
            .....|:..    :|::|:||            ||:.| ..|:|.:.:...|.  |:||.| .|:
  Rat   509 SEDSSTAENSEHESTENEAPE------------PPVRVLSTAEGPQLRPLGPAVGKTSQDE-RQL 560

  Fly  1040 TVIEQPATKAQLHQLAQADSEPRKKTELSQSLKDALKIINDSLLKKLGAKP--ISSQSLKSAKAT 1102
            :...|...:|::  ....|.|...:.:||..|..|.     ..|:|....|  ::.:.||.|..|
  Rat   561 SQESQRVPEAKV--APGPDPEEEIRMDLSPDLISAC-----LALEKYLENPNALTERELKVAYTT 618

  Fly  1103 IQDHWFTNSSTGKSDPHQVEDYLDYFESLSIPLLEYCVNLSDSNGNTAMHYAVSHGNFDVVSILL 1167
            :...|...:....:.|..|..:|..|.::|..||:|.||::|||||||:||:|||.||.||..||
  Rat   619 VLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLL 683

  Fly  1168 DSKVCDVNQMNNAGYTSVMLVSLAKLKQPAHRTVVERLFKMADVNIRAKKHCQTALMLAVSHGNG 1232
            ||.||.|:::|.|||:.:||.:||.||.......:.:||::.:||.:|.:..|||||||||||..
  Rat   684 DSGVCQVDKLNRAGYSPIMLTALATLKTQDDIDTILQLFRLGNVNAKASQAGQTALMLAVSHGRV 748

  Fly  1233 DMVNMLLDAGADINIQDEDGSTALMCAAEHGRVDVIKHLLSHPECDSLVTDVDGSTAFKIAWQAG 1297
            |:|..||....|:|:||||||||||||.|||..::...||:.|.||..:||.|||||..:|..||
  Rat   749 DVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLLAVPSCDISLTDRDGSTALMVALDAG 813

  Fly  1298 HRDVGLLIY 1306
            ..::..::|
  Rat   814 QSEIASMLY 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kank	NP_001097318.1	KN_motif	76..>102	CDD:288894	9/15 (60%)
		ANK	1141..1272	CDD:238125	71/130 (55%)
		ANK repeat	1146..1215	CDD:293786	35/68 (51%)
		Ank_4	1147..1239	CDD:290365	48/91 (53%)
		ANK repeat	1217..1249	CDD:293786	17/31 (55%)
		Ank_4	1221..1272	CDD:290365	31/50 (62%)
		Ank_4	1252..1301	CDD:290365	26/48 (54%)
Kank2	XP_006242651.1	KN_motif	31..>59	CDD:314884	11/24 (46%)
		LGT	<438..580	CDD:320995	34/167 (20%)
		Ank_2	<624..687	CDD:315466	30/62 (48%)
		ANK repeat	624..660	CDD:293786	10/35 (29%)
		ANK	657..788	CDD:238125	71/130 (55%)
		ANK repeat	662..731	CDD:293786	35/68 (51%)
		ANK repeat	735..765	CDD:293786	17/29 (59%)
		ANK	762..>821	CDD:238125	31/58 (53%)
		ANK repeat	767..799	CDD:293786	17/31 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0514
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60237at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44814
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24168
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.900