Protein Alignment Cyp317a1 and CYP4F2

DIOPT Version :10

• Sequence 1: NP_611004.1
• Gene: Cyp317a1 / 36667
• FlyBaseID: FBgn0033982
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 142/551 - (25%)
• Similarity: 247/551 - (44%)
• Gaps: 96/551 - (17%)

  Fly     2 WIIFLIIGLLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKLW---------PIIR--QIMTQTL 55
            |::.|::|...|...||....|.|  |..|.|....:.|::.|         |...  :::||.:
Human    19 WLLLLLVGASWLLAHVLAWTYAFY--DNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLV 81

  Fly    56 STEAMKAEHYSAIYKKFKGSGPFCGFYALLQPRALILDRELIRQIM---------IKDFWNFNDR 111
            :|       |...:|.:  .||.....:|..|       ::||.::         .|.|::|
Human    82 AT-------YPQGFKVW--MGPISPLLSLCHP-------DIIRSVINASAAIAPKDKFFYSF--- 127

  Fly   112 GLYCNQKSDPLSGD-LYALRGESWKEMRQKLDPSLEGDRMSLL--YDCLYEEAEQLLLTVNSTLM 173
                   .:|..|| |....|:.|...|:.|.|:.   ..::|  |..::.|:..::......|.
Human   128 -------LEPWLGDGLLLSAGDKWSRHRRMLTPAF---HFNILKPYMKIFNESVNIMHAKWQLLA 182

  Fly   174 SQPHSTVHIQKIMRRYVLSSLAKCVFGLNAE-QRKTYPLEDFEQMTELA--LNSHKHGYLMNLMM 235
            |:..:.:.:.:.:....|.||.||||..::. |.|  |.|....:.||:  ::...|..|:::..
Human   183 SEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEK--PSEYIAAILELSALVSKRHHEILLHIDF 245

  Fly   236 I--------RFPNFCRMLRMRRTPKQAEEYFIKLLTSIVEQRETSGKPQ--KDYLQLLIDVKALE 290
            :        ||...||::.             ....:::::|..:...|  .|:||.....|.|:
Human   246 LYYLTPDGQRFRRACRLVH-------------DFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLD 297

  Fly   291 FITHQYEADKELGAHLQNE-LAAHAVVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVKKAI 354
            ||.....:..|.|..|.:| :.|.|..|:..|::.||:.||:|||.||.|||.|.|.|:||::.:
Human   298 FIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELL 362

  Fly   355 -ERHDGHITHEGIKSLSFMGQVINETLRMHPITPYILRRTLNDYAVPDHPKYILVKELFLIIPTH 418
             :|....|..:.:..|.|:...:.|:||:||..|.|.|....|..:||  ..::.|.:..:|...
Human   363 KDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPD--GRVIPKGIICLISVF 425

  Fly   419 AIHHDPDIYPDPEEFKPDRWSGPRDSLQEQG--TWFGFGVGARSCIGIQFAQLQLRLALALLLSE 481
            ..||:|.::||||.:.|.|:.  .::::|:.  .:..|..|.|:|||..||..::::.|||.|..
Human   426 GTHHNPAVWPDPEVYDPFRFD--PENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLR 488

  Fly   482 Y----EFSLNTRKP--LINLEDGIALTLMPL 506
            :    :.:...|||  ::..|.|:.|.:.||
Human   489 FRVLPDHTEPRRKPELVLRAEGGLWLRVEPL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_611004.1	CYP6-like	74..509	CDD:410679	123/468 (26%)
CYP4F2	NP_001073.3	CYP4F	74..515	CDD:410772	125/488 (26%)