Protein Alignment Cyp317a1 and TBXAS1

DIOPT Version :9

• Sequence 1: NP_001286435.1
• Gene: Cyp317a1 / 36667
• FlyBaseID: FBgn0033982
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 121/516 - (23%)
• Similarity: 218/516 - (42%)
• Gaps: 114/516 - (22%)

  Fly    76 GPFCGFYALLQPRALILDRELIRQIMIKDFWNFNDR---GLYCNQKSDPLSGDLYALRGESWKEM 137
            ||.||:|...:...:|.:.::|:|:::::|.||.:|   ||.....:|    .:..||.:.|:|:
Human    75 GPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVAD----SVLFLRDKRWEEV 135

  Fly   138 RQKLDPSLEGDRMSLLYDCLYEE-------AEQLLLTVNSTLMSQP---HSTVH----------- 181
            |..|..:...::::.|...:.:|       .:|....:..|.:|:|   :..:|
Human   136 RGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMVPL 200

  Fly   182 -----------------------IQKIMRRYVLSSLAKCVFGLNAEQRKTYPLEDFEQMTELALN 223
                                   ||:....|....:|...||.        |::.: |..|....
Human   201 ISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGT--------PVDSW-QAPEDPFV 256

  Fly   224 SHKHGYL-------MNLMMIRFPNFCRMLRMRRTPKQAEE---YFIKLLTSIVEQR--ETSGKPQ 276
            .|...:.       :.::::.||:....|......|..:|   :|.||:.:::..|  :.:.:.:
Human   257 KHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERR 321

  Fly   277 KDYLQLLID---------VKALEFI-------------THQYEADKELGAHLQNELAAHAVVFLK 319
            :|:||:::|         |:..:.:             :.|::..........:|:...|.:||.
Human   322 RDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLI 386

  Fly   320 AGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERH---DGHITHEGIKSLSFMGQVINETLR 381
            ||||...||||:..|.||.:|:.|.::..||....|:|   :.....||   |.::..||.||||
Human   387 AGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEG---LPYLDMVIAETLR 448

  Fly   382 MHPITPYILRRTLNDYAVPDHPKYILVKEL----FLIIPTHAIHHDPDIYPDPEEFKPDRWSGPR 442
            |:|......|....|..|       |.:.:    .|.:...|:||||:.:|.||.|.|:|::...
Human   449 MYPPAFRFTREAAQDCEV-------LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEA 506

  Fly   443 DSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFSL--NTRKPLINLEDGIAL 501
            .......|:..||.|.|||:|::...|:::|.|..:|.::.|..  .|:.|| .||...||
Human   507 RQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPL-QLESKSAL 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	109/477 (23%)
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	121/516 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920