Protein Alignment Cyp317a1 and CYP3A43

DIOPT Version :9

• Sequence 1: NP_001286435.1
• Gene: Cyp317a1 / 36667
• FlyBaseID: FBgn0033982
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 134/547 - (24%)
• Similarity: 245/547 - (44%)
• Gaps: 116/547 - (21%)

  Fly    10 LLVLGLLVLLIIAARYQRDYWRYLDIPHERP-----------KKLWPIIRQIMTQTLSTEAMKAE 63
            :||...||||.|...:....::.|.||...|           :.||...|:.           .|
Human    13 VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDREC-----------NE 66

  Fly    64 HYSAIYKKFKGSGPFCGFYALLQPRALILDRELIRQIMIKDFWNFNDRGLYCNQKSDPLSGDLYA 128
            .|          |...|.|...||..:|:|.::|:.:::|:.::     ::.||.  || |.:..
Human    67 KY----------GEMWGLYEGQQPMLVIMDPDMIKTVLVKECYS-----VFTNQM--PL-GPMGF 113

  Fly   129 LRG-------ESWKEMRQKLDPSLEG----DRMSLLYDC-------LYEEAEQLLLTVNSTLMSQ 175
            |:.       |.||.:|..|.|:...    :.:.::..|       |.:|||      ||
Human   114 LKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAE------NS----- 167

  Fly   176 PHSTVHIQKIMRRYVLSSLAKCVFGLNAEQRKTYPLEDF-EQMTELALNSHKHGYLMNLMMIRF- 238
              .:::::.....|.:..:...:||:|.:.... |.:.| :.|.:|........:|:.:.:..|
Human   168 --KSINLKDFFGAYTMDVITGTLFGVNLDSLNN-PQDPFLKNMKKLLKLDFLDPFLLLISLFPFL 229

  Fly   239 -PNFCRMLRMRRTPKQAEEYFIKLLTSIVEQRETSGKPQK----DYLQLLIDVK-ALEFITHQYE 297
             |.| ..|.:...||.. .:|:|  .||...:|:..|.::    |:.|.:||.: :.|..:|:..
Human   230 TPVF-EALNIGLFPKDV-THFLK--NSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKAL 290

  Fly   298 ADKELGAHLQNELAAHAVVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHIT 362
            :|.        ||.|.:::.:.|.|:.|:.||.:::||||.||::|.:::||: .|:..:...:|
Human   291 SDL--------ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEI-DAVLPNKAPVT 346

  Fly   363 HEGIKSLSFMGQVINETLRMHPITPYILRRTLNDYAVPDHPKYILVKELFLIIPTHAIHHDPDIY 427
            ::.:..:.::..|:|||||:.|:...:.|....|..:..   ..:.|.|.:::|.:|:||||..:
Human   347 YDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEING---VFIPKGLAVMVPIYALHHDPKYW 408

  Fly   428 PDPEEFKPD-RWSGPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFS------ 485
            .:||:|.|: |:|.......:...:..||.|.|:|||::||...::||:...|..:.|.
Human   409 TEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQ 473

  Fly   486 ----------LNTRKPL---INLEDGI 499
                      |...||:   ::|.|||
Human   474 IPLKLDNLPILQPEKPIVLKVHLRDGI 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	111/464 (24%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	121/513 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820