DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp317a1 and Cyp3a57

DIOPT Version :9

Sequence 1:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001093650.1	Gene:	Cyp3a57 / 622127	MGIID:	3646373	Length:	503	Species:	Mus musculus

Alignment Length:	508	Identity:	123/508 - (24%)
Similarity:	252/508 - (49%)	Gaps:	49/508 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHYSAIYKKFKG 74
            :|::..||...|...|....::.|.||..:|..|:..|...:......:       ...|||:
Mouse    13 VLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGNIINYLDGMWKFD-------DDCYKKY-- 68

  Fly    75 SGPFCGFYALLQPRALILDRELIRQIMIKDFWN-FNDR------GLYCNQKSDPLSGDLYALRGE 132
             |...|||...||...|:|.|:|:.:::|:.:: |.:|      |..  :||..:|.|      |
Mouse    69 -GKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRPFGPVGFL--KKSITISED------E 124

  Fly   133 SWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHIQKIMRRYVLSSLAKC 197
            .||.:|..|.|:....::..::..:.:..:  :|..|.....:....::::.|...|.:..:...
Mouse   125 EWKRLRTLLSPTFTSSKLKEMFPIMRQYGD--ILVRNLRREEEKEEPINMKDIFGAYSMDVITGT 187

  Fly   198 VFGLNAEQRKTYPLEDFEQMTELALN-SHKHGYLMNLMMIRF--PNFCRMLRMRRTPKQAEEYFI 259
            ..|:|.:.... |.:.|.|..:..|. .....:|:::::..|  |.: .||.:...|:|:..:|.
Mouse   188 SCGVNIDSLNN-PQDPFVQKIKKILKFKFFDPFLLSVVLFPFLTPIY-EMLNLSIFPRQSMNFFK 250

  Fly   260 KLLTSIVEQR-ETSGKPQKDYLQLLIDVKALEFITHQYEADKELGAHLQNELAAHAVVFLKAGYE 323
            |.:..:.:.| :.:.|.:.|:|||:::       |...:..:.|.|....|:||..::|:..||:
Mouse   251 KFVKKMKKDRLDYNQKNRVDFLQLMMN-------TQNSKGQESLKALSDLEMAAQTLIFIFGGYD 308

  Fly   324 QTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMGQVINETLRMHPITPY 388
            .|:.::|:::||||.||::|.::::|:.:|:. :...:|::.:..:.::..|:||:||::|:...
Mouse   309 GTSTSISFIMYELATHPDVQKKLQDEIDRALP-NKAPVTYDALMDMEYLDMVVNESLRLYPVVSR 372

  Fly   389 ILRRTLNDYAVPDHPKYILVKELFLIIPTHAIHHDPDIYPDPEEFKPDRWSGPRDSLQEQGTWFG 453
            |.|.:..|..:  |..:| .|...::||.:.:|.||:.:|:||:|.|:|:|.......:...:..
Mouse   373 IDRFSKKDVEI--HGVFI-PKGTIVMIPIYPLHRDPEYWPEPEDFCPERFSKENKGNIDPYIYMP 434

  Fly   454 FGVGARSCIGIQFAQLQLRLALALLLSEYEFSLNTRKPLINLEDGIALTLMPL 506
            ||.|.|:|||::||.:.::||:..:|..:     |.:|....:..:.::..|:
Mouse   435 FGNGPRNCIGMRFALISVKLAVTGVLQNF-----TVQPCEETQIPVKISRQPI 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	107/437 (24%)
Cyp3a57	NP_001093650.1	p450	39..493	CDD:278495	116/482 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820