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Protein Alignment Cyp317a1 and PTGIS

DIOPT Version :9

Sequence 1:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_000952.1	Gene:	PTGIS / 5740	HGNCID:	9603	Length:	500	Species:	Homo sapiens

Alignment Length:	582	Identity:	115/582 - (19%)
Similarity:	202/582 - (34%)	Gaps:	170/582 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IIGLLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHYSAIYKK 71
            ::|||...||:||:...|.:|        |.|.|..|
Human     6 LLGLLAALLLLLLLSRRRTRR--------PGEPPLDL---------------------------- 34

  Fly    72 FKGSGPFCGFYAL--LQPRALILDRELIRQIMIKDFWNFNDRGLYCNQKSDPLSGDLYALRGESW 134
              ||.|:.| |||  .:..|..|.|...:.   .|.:.....|.|.....||.|.|...     |
Human    35 --GSIPWLG-YALDFGKDAASFLTRMKEKH---GDIFTILVGGRYVTVLLDPHSYDAVV-----W 88

  Fly   135 KEMRQKLD---------------------PSLEGDRMSL---------LYDCLYEEAEQLLLTVN 169
             |.|.:||                     ||.|..||.|         |.:.:|.....:||. :
Human    89 -EPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLG-D 151

  Fly   170 STLMSQPHSTVHIQKIMRRYVLSSLAKCVFGLNA--------EQRKTYPLEDFEQMTE------- 219
            :|........:.:......::|.:....::|:.|        .|.:.:..:.|....:
Human   152 ATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPK 216

  Fly   220 -----LALNSHKHGYLMNLMMIRFPNFCRMLRMRRTPKQAEEYFIKLLTSIVEQRETSGKPQKDY 279
                 |::....|...:...:.:..:..|:.|.....|..|.|.:.|
Human   217 LARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHL------------------ 263

  Fly   280 LQLLIDVKALEFITHQYEADKELGAHLQNELAAHAVVF-LKAGYEQTANTLSYVLYELALHPELQ 343
                                :|:|  :..|:.|.|:|. |.|..........::|..|..:||..
Human   264 --------------------EEMG--VSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEAL 306

  Fly   344 VRVREEVKKAIERHDGHIT------HEGIKSLSFMGQVINETLRMHPITPYILRRTLNDYAVP-- 400
            ..||.|::..:.:.:..::      .:.:.|...:..|::|:||: ...|:|.|..:.|.|:|
Human   307 AAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPFITREVVVDLAMPMA 370

  Fly   401 DHPKYILVK-ELFLIIPTHAIHHDPDIYPDPEEFKPDRWSGP---------RDSLQEQGTWFGFG 455
            |..::.|.: :..|:.|..:...||:||.|||.||.:|:..|         :|..:.:.....:|
Human   371 DGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWG 435

  Fly   456 VGARSCIGIQFAQLQLRLALALLLSEYEFSLNTRKPLINLEDGIA---LTLMPLGVIEPGNE 514
            .|...|:|..:|...::..:.|:|...:..      |||.:..|.   |:....|:::|.::
Human   436 AGHNHCLGRSYAVNSIKQFVFLVLVHLDLE------LINADVEIPEFDLSRYGFGLMQPEHD 491

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.