DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp317a1 and Cyp6a17

DIOPT Version :9

Sequence 1:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	165/519 - (31%)
Similarity:	288/519 - (55%)	Gaps:	39/519 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LIIGLLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKL------WPIIRQIMTQTLSTEAMKAEH 64
            |::.|:|: :|.||:.|||.:..||:...|||:....|      ||..|.|           ||.
  Fly     2 LLLALIVV-ILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHI-----------AEI 54

  Fly    65 YSAIYKKFKGSG-PFCGFYALLQPRALILDRELIRQIMIKDFWNFNDRGLYCNQKSDPLSGDLYA 128
            :...|.|:|.|. ||.||:......|::.|.||:::::||||.:|.:||::.|:..||||..|::
  Fly    55 FRDYYFKYKNSDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDPLSATLFS 119

  Fly   129 LRGESWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHIQKIMRRYVLSS 193
            :.|:.|:.:|.||.|:....:|..::..:.:..|::.....|...:.....:.:..::.||....
  Fly   120 IEGQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADV 184

  Fly   194 LAKCVFGLNAEQRKTY-PLEDFEQMTELALNSHKHGYLMNLMMIRFPNFCRMLRMRRTPKQAEEY 257
            :..|.||||.  ...| |..:|..:.:.|:..|::|.::::.:..||...|.||::...::||::
  Fly   185 IGNCAFGLNC--NSLYDPKAEFVSIGKRAITEHRYGNMLDIFLFGFPKLSRRLRLKLNIQEAEDF 247

  Fly   258 FIKLLTSIVEQRETSGKPQKDYLQLLIDVKALEFITHQYEADKELGAHLQNELAAHAVVFLKAGY 322
            :.|::...::.|..:.:.:.|::..||     |...::...:.|.|... |||.|.|.:|..||:
  Fly   248 YTKIVRETIDYRLRTKEKRNDFMDSLI-----EMYKNEQSGNSEDGLTF-NELLAQAFIFFVAGF 306

  Fly   323 EQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMGQVINETLRMHPITP 387
            |.::.|:.:.|||||.:.::|.::|||:.....:|:...|:||||.:.::.||:.||||.:|:..
  Fly   307 ETSSTTMGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLA 371

  Fly   388 YILRRTLNDYAVPDHPKYILVKELFLIIPTHAIHHDPDIYPDPEEFKPDRWSGPRDSLQEQGTWF 452
            ::.|.|..|:: |:.|||.:.|...::||...||:||||||:||.|||:|::....:.:...||.
  Fly   372 HLTRMTDTDFS-PEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCTWL 435

  Fly   453 GFGVGARSCIGIQFAQLQLRLALALLLSEYEFSLN--TRKP--------LINLEDGIALTLMPL 506
            .||.|.|:|||::|..:|..:.||.|:..|:||::  |:.|        ||:.|:||.|.:..|
  Fly   436 PFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHLKVEKL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	134/434 (31%)
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	144/461 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471836
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900