DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp317a1 and Cyp6a20

DIOPT Version :9

Sequence 1:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	495	Identity:	148/495 - (29%)
Similarity:	279/495 - (56%)	Gaps:	28/495 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHYSAIYKKF-- 72
            :|::|::..:........:||:...|||:.||         :....::|.||..|::.|:|:.
  Fly     6 VLLIGVITFVAWYVHQHFNYWKRRGIPHDEPK---------IPYGNTSELMKTVHFADIFKRTYN 61

  Fly    73 ----KGSGPFCGFYALLQPRALILDRELIRQIMIKDFWNFNDRGLYCNQKSDPLSGDLYALRGES 133
                |..|||.|||...:...::.|.:..:.::|::|..|:|||::.|::.||||.:|..:.|:.
  Fly    62 KLRNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRGVFHNERDDPLSANLVNIDGQK 126

  Fly   134 WKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHIQKIMRRYVLSSLAKCV 198
            ||.:||||.|:....:|..::..:....::|:.....| .|....::.|..::.|:....:..|.
  Fly   127 WKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGET-ASADSDSMEITNVVARFTADVIGSCA 190

  Fly   199 FGLNAEQRKTYPLEDFEQMTELALNSHKHGYLMNLMMIRFPNFCRMLRMRRTPKQAEEYFIKLLT 263
            |||:...... |...|.||...|:...:||..|:|::...|.....|||:.|.::.|::::.::.
  Fly   191 FGLDCHSLSD-PKAKFVQMGTTAITERRHGKSMDLLLFGAPELAAKLRMKATVQEVEDFYMNIIR 254

  Fly   264 SIVEQRETSGKPQKDYLQLLIDVKALEFITHQYEADKELGAHLQNELAAHAVVFLKAGYEQTANT 328
            ..|:.|..:...:.|::.:||::| |:|    ...|||.|... ||:||.|.:|..||:|.::.|
  Fly   255 DTVDYRVKNNVKRHDFVDMLIEMK-LKF----DNGDKENGLTF-NEIAAQAFIFFLAGFETSSTT 313

  Fly   329 LSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMGQVINETLRMHPITPYILRRT 393
            :.:.|||||.|.::|.::|.|:...:::|:|.:.::.::.::::.:||:||:|..|:..:::|..
  Fly   314 MGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTYLEKVIDETMRKRPVVGHLIRVA 378

  Fly   394 LNDYAVPDHPKYILVKELFLIIPTHAIHHDPDIYPDPEEFKPDRWSGPRDSLQEQG--TWFGFGV 456
            ...|. ..:|||.:.|...:|:||.||||||:.||:||:|.|:|:.  .|.:|::.  |:..||.
  Fly   379 TQHYQ-HTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFD--EDQVQQRPACTFLPFGD 440

  Fly   457 GARSCIGIQFAQLQLRLALALLLSEYEFSLNTRKPLINLE 496
            |.|:|||::|.::|:.:.:|||:..::|..:..|.::.||
  Fly   441 GPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTVVPLE 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	132/434 (30%)
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	143/469 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.970