DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp317a1 and Cyp9h1

DIOPT Version :9

Sequence 1:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	133/508 - (26%)
Similarity:	245/508 - (48%)	Gaps:	38/508 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLVLGLLVLLII------AARYQRDYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHYSAI 68
            ::.|.|.::|::      .|:|  |.:....:.||:|   ||:|..|..:.:.......:....:
  Fly     5 MIALALFIILLVLLYKWSVAKY--DVFSERGVSHEKP---WPLIGNIPLKAMIGGMPVLKKMIEL 64

  Fly    69 YKKFKGSGPFCGFYALLQPRALILDRELIRQIMIKDFWNF-NDRGLYCNQKSDPLSGDLYALRGE 132
            :.|..|| |..|.|||......:.|.|||:.|.||:|.:| |...::.|.:...||..|.:||..
  Fly    65 HTKHTGS-PVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQESILSKSLISLRDG 128

  Fly   133 SWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTL-MSQPHS-TVHIQKIMRRYVLSSLA 195
            .|||||..|.|:..|.:|.::||.:...:|:.::.:...| :||..| .:.::....|:....:|
  Fly   129 RWKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIA 193

  Fly   196 KCVFG--LNAEQRKTYPLEDFEQMTELALNSHKHGYLMNLMMIRFPNFCRMLRMRRTPKQAEEYF 258
            ...||  :|:.:||.   .:|.::.:..........:..::...||...::||::....:..:||
  Fly   194 TVAFGISINSFRRKD---NEFFRIGQAMSRISAWSVVKAMLYALFPRLMKVLRIQVLDTKNIDYF 255

  Fly   259 IKLLTSIVEQRETSGKPQKDYLQLLIDVKALEFITHQYEADKEL--GAHLQNELAAHAVVFLKAG 321
            ..|:|:.:..|:.....:.|.:.||::.|.........::..||  .....::|.|..::|..||
  Fly   256 SSLVTAAMRYRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAG 320

  Fly   322 YEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGH-ITHEGIKSLSFMGQVINETLRMHPI 385
            :|..:::|.::.:||.|:|.:|.|:.||:....|...|. :|::.:..:.::..|:.|.||..|.
  Fly   321 FEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTKMKYLDMVVLEALRKWPP 385

  Fly   386 TPYILRRTLNDYAVPDHPKYILVKELF-------LIIPTHAIHHDPDIYPDPEEFKPDRWSGPRD 443
            :....|....|..:.|...    ::||       |.||..::||||:.:.|||.|.|:|::.  .
  Fly   386 SISTDRECRQDIDLFDENG----QKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFAD--G 444

  Fly   444 SLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEF--SLNTRKPLIN 494
            ...|...:..||||.|:|||.:.|.::|:..:..||..::.  :..|.:.|:|
  Fly   445 HALESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLN 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	118/441 (27%)
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	125/473 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461229
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900