DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp317a1 and Cyp6t3

DIOPT Version :9

Sequence 1:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	119/519 - (22%)
Similarity:	226/519 - (43%)	Gaps:	52/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLVLGLLVLLIIA----ARYQRDYWRYLDIPHERPKKLWPI--IRQIMTQTLSTEAMKAEHYSAI 68
            :|::.||:|.|:.    .|::.||:|...|||..|....|:  :.|::...:|        :..:
  Fly     1 MLLIWLLLLTIVTLNFWLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRIS--------FGDL 57

  Fly    69 YKKF-----KGSGPFCGFYALLQPRALILDRELIRQIMIKDFWNFNDRGLYCNQKSDPLSG-DLY 127
            :::.     .|.....||:....|..::.|.|||||::||:|.||.:| .......||:.. .|.
  Fly    58 FRQLYADPRNGQAKIVGFFIFQTPALMVRDPELIRQVLIKNFNNFLNR-FESADAGDPMGALTLP 121

  Fly   128 ALRGESWKEMRQKLDPSLEGDRM-SLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHIQKIMRRYVL 191
            ..:...|||.||.:.......|| .::|..:.:.|..|...:|..|..:....:.:.::.:.|..
  Fly   122 LAKYHHWKESRQCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLPLGRMCQLYTT 186

  Fly   192 SSLAKCVFGLNAEQRKTYPLEDFEQMTELALNSHKHGYLMNLMMIRFPNFCRMLRMRRTPKQAEE 256
            .......:.||....:....|...:..|| .|::....|..:.:...|.:..:|:    ||...|
  Fly   187 DVTGNLFYSLNVGGLRRGRSELITKTKEL-FNTNPRKVLDFMSVFFLPKWTGVLK----PKVFTE 246

  Fly   257 YFIKLLTSIVEQRETSGKPQKDYLQLLIDVKALEFITHQYEADKELGAHLQNELAAHAVVFLKAG 321
            .:.:.:..:|:...   :|.|..|...:....|...::.|....:.       :|:.|.:.|.||
  Fly   247 DYARYMRHLVDDHH---EPTKGDLINQLQHFQLSRSSNHYSQHPDF-------VASQAGIILLAG 301

  Fly   322 YEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMGQVINETLRMHPIT 386
            :|.::..:.:.|||||..|::|.|:|.|:::|. .....::::.:.:|.::..|..|.||::|..
  Fly   302 FETSSALMGFTLYELAKAPDIQERLRSELREAF-ISTATLSYDTLMTLPYLKMVCLEALRLYPAA 365

  Fly   387 PYILRRTLND----YAVPDHPKYILVKELFLIIPTHAIHHDPDIYPDPEEFKPDRWSGPRDSLQE 447
            .::.|...:.    :::..|..:|:...:...|....:|.|...:|:|..|.|:|:...|.....
  Fly   366 AFVNRECTSSASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIH 430

  Fly   448 QGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEY----------EFSLNTRKPLINLEDGIAL 501
            ..|:..||.|...|||.:...|||:|.:..:|.:|          |...|.:..::..|:.|.|
  Fly   431 PMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	96/439 (22%)
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	104/476 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461085
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900