DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp317a1 and Cyp6w1

DIOPT Version :9

Sequence 1:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	137/509 - (26%)
Similarity:	240/509 - (47%)	Gaps:	73/509 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLVLG-LLVLLIIAARYQRDYWRYLDIPHERPKKLWPII---RQIMTQTLSTEAMKAEHYSAIYK 70
            ||:|| |.::..|..|....:|....:.:.||   :|::   |:.:|       .|...:..|.|
  Fly     4 LLLLGSLTIVFYIWQRRTLSFWERHGVKYIRP---FPVVGCTREFLT-------AKVPFFEQIQK 58

  Fly    71 KFKGSG----PFCGFYALLQPRALILDRELIRQIMIKDFWNFNDRGLYCNQKSDPLS-GDLYALR 130
            ..:..|    ||.|.|...:|..:|.|.|||:.:|||.|..||:|.|..:..:|.|. .:|:..|
  Fly    59 FHEAPGFENEPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDALGYKNLFFAR 123

  Fly   131 GESWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPH-----STVHIQKIMRRYV 190
            ...|:|:|.|:.|.....::..:|        .|::.:...|.....     :.|.::.:..|:.
  Fly   124 SPGWRELRTKISPVFTSGKIKQMY--------PLMVKIGKNLQDSAERLGSGTEVQVKDLCSRFT 180

  Fly   191 LSSLAKCVFGLNAEQRKTYPLEDFEQMTELALNSHKHGYLMNLMMIR---------FPNFCRMLR 246
            ...:|...||:.|...:....|.|          :.:..:.:|.:.|         .|....:.|
  Fly   181 TDLIATIAFGVEANALQDAKSEFF----------YHNRAIFSLTLSRGIDFAIIFMIPALASLAR 235

  Fly   247 MRRTPKQAEEYFIKLLTSIVEQRETSGKPQKDYLQLLIDVKALEFITHQYEADKELGAHLQNELA 311
            ::...::..::....:..::::||.:|:.:.|.:.:|:.:|. |...:..:..||:..   :.|.
  Fly   236 VKLFSRETTKFIRSSVNYVLKERERTGEKRNDLIDILLALKR-EAAANPGKMSKEVDL---DYLV 296

  Fly   312 AHAVVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMGQVI 376
            |.|.||..||:|.:|:|::..|||||.:..||.|:|:|:.......| ||::|.|:.:.::.||:
  Fly   297 AQAAVFQTAGFETSASTMTMTLYELAKNEALQDRLRQEIVDFFGDED-HISYERIQEMPYLSQVV 360

  Fly   377 NETLRMHPITPYILRR----------TLNDYAVPDHPKYILVKELFLIIPTHAIHHDPDIYPDPE 431
            |||||.:||..||.|.          ||..:...:.|     ..:.:.:.|.|:|.||..:||||
  Fly   361 NETLRKYPIVGYIERECSQPAEGERFTLEPFHNMELP-----HGMSIYMSTVAVHRDPQYWPDPE 420

  Fly   432 EFKPDRW-SGPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEF 484
            ::.|:|: |..||:| ....:..||||.|:|||::...||.:|.|..:|..:.|
  Fly   421 KYDPERFNSSNRDNL-NMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRF 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	123/459 (27%)
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	129/479 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461133
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900