DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp317a1 and Cyp28c1

DIOPT Version :9

Sequence 1:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	128/547 - (23%)
Similarity:	238/547 - (43%)	Gaps:	97/547 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IIGLLVLGLLVLL-----IIAARYQRDYWRYLDIPHER--------PKKLWPIIRQIMTQTLSTE 58
            :.|.|:||:..||     .:.:.:  .:||...:...|        |..:||  ||..|..:..
  Fly     1 MFGSLLLGIATLLGAIYAFLVSNF--GHWRRRGVTEPRALPLFGSFPNMIWP--RQHFTMDMRD- 60

  Fly    59 AMKAEHYSAIYKKFKGSGPFCGFYALLQPRALILDRELIRQIMIKDFWNF--NDRGLYCNQKSDP 121
                     ||..::.:..:.|.|.|..|:.|:|:..|:.:|.:..|.:|  ||.....:...|.
  Fly    61 ---------IYMHYRNTHSYVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDR 116

  Fly   122 LSG-DLYALRGESWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHIQKI 185
            |.. :.:.|.||.|:..|......|...|:...:..:......|...:  .:.|.....:....:
  Fly   117 LVALNPFVLEGEEWRHQRAVFSTLLTNGRIRTTHAIMQRVCLDLCQFI--AIKSAGGKDLDCIDL 179

  Fly   186 MRRYVLSSLAKCVFGLNAEQRKTYPL----EDFEQMTE---LALNSHKHGYLMNLMMIRFPNFCR 243
            ..|:...||..||.|:.|......||    ::.|...|   ||:....||.        |||..|
  Fly   180 GLRFTGESLFDCVLGIQARTFTDNPLPVVRQNHEMSAENRGLAIAGAVHGL--------FPNLPR 236

  Fly   244 MLRMRRTPKQAEEYFIKLLTSIVEQRETSGKPQKDYLQLLIDVKALEFITHQYEADKELGAHLQN 308
            .||.:..|:..:.::.::::..:..|.:..:.:.|            ||.|..|..:||... :.
  Fly   237 WLRPKVFPRSHDRFYGQMISEALRLRRSKHQERND------------FINHLLEMQRELDLS-EE 288

  Fly   309 ELAAHAVVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITH-EGIKSLSFM 372
            ::|:||:.|:..|.:.|:|::::.|..|..:|:.|.|:.||::  :....|::.. :.:..|.::
  Fly   289 DMASHAMTFMFDGLDTTSNSIAHCLLLLGRNPDCQRRLYEELQ--LVNPGGYLPDLDALIDLPYL 351

  Fly   373 GQVINETLRMHPITPYILRRTLNDYAV-------------PDHPKYILVKELFLIIPTHAIHHDP 424
            ....||:||::|...:..:....:|.:             .||          :::|.:|:|:||
  Fly   352 SACFNESLRIYPAGGWASKTCTKEYELRGSHHSEPLKLRPGDH----------VMVPIYALHNDP 406

  Fly   425 DIYPDPEEFKPDRW-SGPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFSLNT 488
            |:||:|:.|:|:|: .|...:.::||.:.|||.|.|.|:|::......:.|||.::..:|..::.
  Fly   407 DLYPEPDVFRPERFLDGGLKNCKQQGIFLGFGNGPRQCVGMRLGLAMAKAALAAIVQRFEVVVSP 471

  Fly   489 R-------KPLINL---EDGIALTLMP 505
            |       .|||.:   :.||.|..:|
  Fly   472 RTLNGTELDPLIFVGVHKGGIWLQFVP 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	108/459 (24%)
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	116/498 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460929
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900