Protein Alignment Cyp317a1 and Cyp3a2

DIOPT Version :9

• Sequence 1: NP_001286435.1
• Gene: Cyp317a1 / 36667
• FlyBaseID: FBgn0033982
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_695224.3
• Gene: Cyp3a2 / 266682
• RGDID: 708379
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 546
• Identity: 138/546 - (25%)
• Similarity: 253/546 - (46%)
• Gaps: 89/546 - (16%)

  Fly     2 WIIFLIIGLLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHYS 66
            |::..:|       ||||.....::...::...||..:|   .|.:..::           .:|.
  Rat    12 WVLLAVI-------LVLLYRLGTHRHGIFKKQGIPGPKP---LPFLGTVL-----------NYYK 55

  Fly    67 AI-------YKKFKGSGPFCGFYALLQPRALILDRELIRQIMIKD----FWNFNDRGLYCNQKSD 120
            .:       |||:   |...|.:....|...|:|.|:|:.:::|:    |.|..|.|
  Rat    56 GLGRFDMECYKKY---GKIWGLFDGQTPVFAIMDTEMIKNVLVKECFSVFTNRRDFG-------- 109

  Fly   121 P--LSGDLYAL-RGESWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHI 182
            |  :.|...:: :.|.||..|..|.|:....|:..::..:.:..:.|:..:...  ::....|.:
  Rat   110 PVGIMGKAVSVAKDEEWKRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQE--AETGKPVTM 172

  Fly   183 QKIMRRYVLSSLAKCVFGLNAEQRKTYPLEDFEQMTELALNSHKHGYLMNLMMIRFP---NFCRM 244
            :|:...|.:..:....||:|.:.... |.:.|.:.|:..|.......|. |.::.||   ....|
  Rat   173 KKVFGAYSMDVITSTSFGVNVDSLNN-PKDPFVEKTKKLLRFDFFDPLF-LSVVLFPFLTPIYEM 235

  Fly   245 LRMRRTPKQAEEYFIKLLTSIVEQR-ETSGKPQKDYLQLLIDV--KALEFITHQYEADKELGAHL 306
            |.:...||.:..:|.|.:..|.|.| ::..|.:.|:|||:::.  .:.:.::|:..:|.
  Rat   236 LNICMFPKDSIAFFQKFVHRIKETRLDSKHKHRVDFLQLMLNAHNNSKDEVSHKALSDV------ 294

  Fly   307 QNELAAHAVVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHI------THEG 365
              |:.|.:|:|:.||||.|::|||:|||.||.||::|.:::||:       ||.:      |::.
  Rat   295 --EIIAQSVIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEI-------DGALPSKAPPTYDI 350

  Fly   366 IKSLSFMGQVINETLRMHPITPYILRRTLNDYAVPDHPKYILVKELFLIIPTHAIHHDPDIYPDP 430
            :..:.::..|:|||||::||...:.|....|..:..   ..:.|...:.|||:|:||||..:|.|
  Rat   351 VMEMEYLDMVLNETLRLYPIGNRLERVCKKDIELDG---LFIPKGSVVTIPTYALHHDPQHWPKP 412

  Fly   431 EEFKPDRWSGPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFS---------L 486
            |||.|:|:|.......:...:..||.|.|:|||::||.:.::|||..:|..:.|.         .
  Rat   413 EEFHPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLK 477

  Fly   487 NTRKPLINLEDGIALTLMPLGVIEPG 512
            .:|:.::..|..|.|.::|...:..|
  Rat   478 LSRQAILEPEKPIVLKVLPRDAVING 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	117/452 (26%)
Cyp3a2	NP_695224.3	CYP3A	67..493	CDD:410743	122/458 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920