DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp317a1 and Tbxas1

DIOPT Version :9

Sequence 1:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_035669.3	Gene:	Tbxas1 / 21391	MGIID:	98497	Length:	533	Species:	Mus musculus

Alignment Length:	547	Identity:	136/547 - (24%)
Similarity:	242/547 - (44%)	Gaps:	81/547 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IIGLL----------VLGLLVLLIIAARYQRDYWRYLD---IPHERPKKLWPIIRQIM---TQTL 55
            ::|||          |..|:.||.:...|....:..|:   |.|.:|.   |.:..:|   ....
Mouse     3 VLGLLKFEVSGTIVTVTLLVALLALLKWYSMSAFSRLEKLGIRHPKPS---PFVGNLMFFRQGFW 64

  Fly    56 STEAMKAEHYSAIYKKFKGSGPFCGFYALLQPRALILDRELIRQIMIKDFWNFNDR---GLYCNQ 117
            .::....|.|          ||.||:|...:...:|.:.::|:|:::::|.||::|   ||....
Mouse    65 ESQLELRERY----------GPLCGYYLGRRMHVVISEPDMIKQVLVENFSNFSNRMASGLEPKM 119

  Fly   118 KSDPLSGDLYALRGESWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHI 182
            .:|    .:..||...|:|:|..|..|...:::..:...:.:..|  ||..:....:......:|
Mouse   120 VAD----SVLLLRDRRWEEVRGALMSSFSPEKLDEMTPLISQACE--LLVAHLKRYAASRDAFNI 178

  Fly   183 QKIMRRYVLSSLAKCVFGLNAEQRKTYPLEDFEQMTELALNSHKHGYLMNLMMIRFPNFCRMLRM 247
            |:....|.:..:|...||...:.:.: |.:.|.|....|........|: ::::.||:....|..
Mouse   179 QRCYCCYTIDVVASVAFGTQVDSQNS-PEDPFVQHCRRASTFCIPRPLL-VLILSFPSIMVPLAR 241

  Fly   248 RRTPKQAEE---YFIKLLTSIVEQR--ETSGKPQKDYLQLLID---------VKALEFITHQY-- 296
            ....|..:|   :|..|:.:::..|  :.:.:.::|:||:::|         |:..:.:....
Mouse   242 ILPNKNRDELNGFFNTLIRNVIALRDQQAAEERRRDFLQMVLDAQHSMNSVGVEGFDMVPESLSS 306

  Fly   297 -EADKELGAHLQ----------NELAAHAVVFLKAGYEQTANTLSYVLYELALHPELQVRVREEV 350
             |..||......          :|:...|.:||.||:|...||||::.|.||.||:.|.|:.:||
Mouse   307 SECTKEPPQRCHPTSTSKPFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEV 371

  Fly   351 KKAIERHDGHITHEGIKSLSFMGQVINETLRMHPITPYILRRTLNDYAVPDHPKYILVKEL---- 411
            ...:.:|.....|...:.|.::..||:|||||:|......|....|..|       |.:.:
Mouse   372 DLFMGKHPAPEYHSLQEGLPYLDMVISETLRMYPPAFRFTREAAQDCEV-------LGQRIPAGT 429

  Fly   412 FLIIPTHAIHHDPDIYPDPEEFKPDRWSGPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALA 476
            .|.|...|:||||:.:|:||.|.|:|::......:...|:..||.|.|||:|::...|.::|.:.
Mouse   430 VLEIAVGALHHDPEHWPNPETFDPERFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTIL 494

  Fly   477 LLLSEYEF--SLNTRKPLINLEDGIAL 501
            .:|.::.|  |..|:.|| .||...||
Mouse   495 QVLHKFRFEASPETQVPL-QLESKSAL 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	113/463 (24%)
Tbxas1	NP_035669.3	p450	47..528	CDD:365848	125/503 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820