Protein Alignment Cyp317a1 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_001286435.1
• Gene: Cyp317a1 / 36667
• FlyBaseID: FBgn0033982
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 133/514 - (25%)
• Similarity: 248/514 - (48%)
• Gaps: 53/514 - (10%)

  Fly    10 LLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHYSAIYKKFKG 74
            ||:...||||.:...:....::.|.||...|   .|.:..|::..........|    .:||:
Human    13 LLLAVSLVLLYLYGTHSHGLFKKLGIPGPTP---LPFLGNILSYHKGFCMFDME----CHKKY-- 68

  Fly    75 SGPFCGFYALLQPRALILDRELIRQIMIKDFWNFNDRGLYCNQKS-DP---LSGDLYALRGESWK 135
             |...|||...||...|.|.::|:.:::|:.::     ::.|::. .|   :...:.....|.||
Human    69 -GKVWGFYDGQQPVLAITDPDMIKTVLVKECYS-----VFTNRRPFGPVGFMKSAISIAEDEEWK 127

  Fly   136 EMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHIQKIMRRYVLSSLAKCVFG 200
            .:|..|.|:....::..:...:.:..:  :|..|....::....|.::.:...|.:..:....||
Human   128 RLRSLLSPTFTSGKLKEMVPIIAQYGD--VLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFG 190

  Fly   201 LNAEQRKTYPLEDFEQMTELALNSHKHGYL--MNLMMIRFPNFCRMLRMRRT---PKQAEEYFIK 260
            :|.:.... |.:.|.:.|:..|   :..:|  ..|.:..||....:|.:...   |::...:..|
Human   191 VNIDSLNN-PQDPFVENTKKLL---RFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRK 251

  Fly   261 LLTSIVEQR-ETSGKPQKDYLQLLIDVKALEFITHQYEADKELGAHLQNELAAHAVVFLKAGYEQ 324
            .:..:.|.| |.:.|.:.|:|||:||.:.    :.:.|:.|.|.   ..||.|.:::|:.||||.
Human   252 SVKRMKESRLEDTQKHRVDFLQLMIDSQN----SKETESHKALS---DLELVAQSIIFIFAGYET 309

  Fly   325 TANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMGQVINETLRMHPITPYI 389
            |::.||:::||||.||::|.:::||: .|:..:....|::.:..:.::..|:|||||:.||...:
Human   310 TSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRL 373

  Fly   390 LRRTLNDYAVPDH--PKYILVKELFLIIPTHAIHHDPDIYPDPEEFKPDRWSGPRDSLQEQGTWF 452
            .|....|..:...  ||.::|     :||::|:|.||..:.:||:|.|:|:|.......:...:.
Human   374 ERVCKKDVEINGMFIPKGVVV-----MIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYT 433

  Fly   453 GFGVGARSCIGIQFAQLQLRLALALLLSEYEFSLNTRKPLINLEDGIALTLMPLGVIEP 511
            .||.|.|:|||::||.:.::|||..:|..:.|     ||.  .|..|.|.|...|:::|
Human   434 PFGSGPRNCIGMRFALMNMKLALIRVLQNFSF-----KPC--KETQIPLKLSLGGLLQP 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	109/438 (25%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	125/488 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920