Protein Alignment Cyp317a1 and CYP3A7

DIOPT Version :9

• Sequence 1: NP_001286435.1
• Gene: Cyp317a1 / 36667
• FlyBaseID: FBgn0033982
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 136/544 - (25%)
• Similarity: 250/544 - (45%)
• Gaps: 82/544 - (15%)

  Fly     2 WIIFLIIGLLVLGLLVLLIIAARYQRDYWRYLDIPHERP-----------KKLWPIIRQIMTQTL 55
            |:      ||.:.|::|.:...| ....::.|.||...|           |..|         |.
Human    12 WL------LLAVSLILLYLYGTR-THGLFKKLGIPGPTPLPFLGNALSFRKGYW---------TF 60

  Fly    56 STEAMKAEHYSAIYKKFKGSGPFCGFYALLQPRALILDRELIRQIMIKDFWN-FNDR------GL 113
            ..|.         |||::   ...|.|...||...|.|.::|:.:::|:.:: |.:|      |.
Human    61 DMEC---------YKKYR---KVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGF 113

  Fly   114 YCNQKSDPLSGDLYALRGESWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHS 178
            ..|..|  ::.|      |.||.:|..|.|:....::..:...:.:..:  :|..|....::...
Human   114 MKNAIS--IAED------EEWKRIRSLLSPTFTSGKLKEMVPIIAQYGD--VLVRNLRREAETGK 168

  Fly   179 TVHIQKIMRRYVLSSLAKCVFGLNAEQRKTYPLEDFEQMTELALNSHK-HGYLMNLMMIRF-PNF 241
            .|.::.:...|.:..:....||::.:.... |.:.|.:.|:..|..:. ..:::::.:..| ...
Human   169 PVTLKHVFGAYSMDVITSTSFGVSIDSLNN-PQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPI 232

  Fly   242 CRMLRMRRTPKQAEEYFIKLLTSIVEQR--ETSGKPQKDYLQLLIDVKALEFITHQYEADKELGA 304
            ...|.:...|::...:..|.:..|.|.|  ||. |.:.|:|||:||        .|...|.|...
Human   233 LEALNITVFPRKVISFLTKSVKQIKEGRLKETQ-KHRVDFLQLMID--------SQNSKDSETHK 288

  Fly   305 HLQN-ELAAHAVVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKS 368
            .|.: ||.|.:::|:.||||.|::.||:::||||.||::|.:|::|:...:. :....|::.:..
Human   289 ALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLP-NKAPPTYDTVLQ 352

  Fly   369 LSFMGQVINETLRMHPITPYILRRTLNDYAVPDH--PKYILVKELFLIIPTHAIHHDPDIYPDPE 431
            |.::..|:|||||:.|:...:.|....|..:...  ||.::|     :||::.:||||..:.:||
Human   353 LEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVV-----MIPSYVLHHDPKYWTEPE 412

  Fly   432 EFKPDRWSGPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFS--LNTRKPLIN 494
            :|.|:|:|.......:...:..||.|.|:|||::||.:.::|||..:|..:.|.  ..|:.||..
Human   413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKL 477

  Fly   495 LEDGIALTLMPLGVIEPGNEERAV 518
            ...|:.||..|: |::..:.:..|
Human   478 RFGGLLLTEKPI-VLKAESRDETV 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	111/451 (25%)
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	127/500 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920