DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp317a1 and Cyp3a13

DIOPT Version :9

Sequence 1:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus

Alignment Length:	513	Identity:	130/513 - (25%)
Similarity:	241/513 - (46%)	Gaps:	47/513 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHYSAIYKKFKG 74
            :|:...||||.:...:....::.|.||..:|   .|.:..|:       |.:...:....:..|.
Mouse    13 MLLATSLVLLYLYGTHSHGIFKKLGIPGPKP---LPFLGTIL-------AYQKGFWECDIQCHKK 67

  Fly    75 SGPFCGFYALLQPRALILDRELIRQIMIKDFWN-FNDRGLYCNQKSDP---LSGDLYALRGESWK 135
            .|...|.|...||...|.|.::|:.:::|:.:: |.:|     ::..|   |...:.....|.||
Mouse    68 YGKMWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNR-----RRFGPVGILKKAISISENEEWK 127

  Fly   136 EMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTL-MSQPHSTVHIQKIMRRYVLSSLAKCVF 199
            .:|..|.|:....|:..::..:.:..:.|:..:...| ..:|.|   ::.|...|.:..:....|
Mouse   128 RIRALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQGLGEGKPTS---MKDIFGAYSMDVITATSF 189

  Fly   200 GLNAEQRKTYPLEDFEQMTELALNSHKHGYLMNLMMIRFPNFCRM---LRMRRTPKQAEEYFIKL 261
            |:|.:.... |.:.|.:..:..|.......|. |.:..||....:   |.:...|:....:|...
Mouse   190 GVNIDSLNN-PQDPFVEKIKKLLKFDIFDPLF-LSVTLFPFLTPVFDALNVSLFPRDVISFFTTS 252

  Fly   262 LTSIVEQRETSGKPQK-DYLQLLIDVKALEFITHQYEADKELGAHLQNELAAHAVVFLKAGYEQT 325
            :..:.|.|....:.|: |:|||:|:       :..|:..:...|....|:.|.:|:|:.||||.|
Mouse   253 VERMKENRMKEKEKQRVDFLQLMIN-------SQNYKTKESHKALSDVEIVAQSVIFIFAGYETT 310

  Fly   326 ANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMGQVINETLRMHPITPYIL 390
            ::.||:.||.||:||::|.::::|:..|:. :....|::.:..:.::..|:|||||::||...:.
Mouse   311 SSALSFALYLLAIHPDVQKKLQDEIDAALP-NKAPATYDTLLQMEYLDMVVNETLRLYPIAGRLE 374

  Fly   391 RRTLNDYAVPDHPKYILVKELFLIIPTHAIHHDPDIYPDPEEFKPDRWSGPRDSLQEQGTWFGFG 455
            |....|..:..   ..:.|...::|||.|:|.||..:|:||||:|:|:|...........:..||
Mouse   375 RVCKTDVEING---LFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYMYLPFG 436

  Fly   456 VGARSCIGIQFAQLQLRLALALLLSEYEFSLNTRKPLINLEDGIALTLMPLGVIEPGN 513
            .|.|:|||::||.:.:::||..:|..:     |.:|....|  |.|.|...|:::|.|
Mouse   437 SGPRNCIGMRFALINMKVALVRVLQNF-----TVQPCKETE--IPLKLSKQGLLQPEN 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	108/435 (25%)
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	123/487 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810