Protein Alignment Cyp317a1 and CYP3A7-CYP3A51P

DIOPT Version :10

• Sequence 1: NP_611004.1
• Gene: Cyp317a1 / 36667
• FlyBaseID: FBgn0033982
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_001243426.2
• Gene: CYP3A7-CYP3A51P / 100861540
• HGNCID: 51504
• Length: 535
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 136/544 - (25%)
• Similarity: 248/544 - (45%)
• Gaps: 81/544 - (14%)

  Fly     2 WIIFLIIGLLVLGLLVLLIIAARYQRDYWRYLDIPHERP-----------KKLWPIIRQIMTQTL 55
            |:      ||.:.|::|.:...| ....::.|.||...|           |..|         |.
Human    12 WL------LLAVSLILLYLYGTR-THGLFKKLGIPGPTPLPFLGNALSFRKGYW---------TF 60

  Fly    56 STEAMKAEHYSAIYKKFKGSGPFCGFYALLQPRALILDRELIRQIMIKDFWN-FNDR------GL 113
            ..|.         |||::   ...|.|...||...|.|.::|:.:::|:.:: |.:|      |.
Human    61 DMEC---------YKKYR---KVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGF 113

  Fly   114 YCNQKSDPLSGDLYALRGESWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHS 178
            ..|..|  ::.|      |.||.:|..|.|:....::..:...:.:..:  :|..|....::...
Human   114 MKNAIS--IAED------EEWKRIRSLLSPTFTSGKLKEMVPIIAQYGD--VLVRNLRREAETGK 168

  Fly   179 TVHIQKIMRRYVLSSLAKCVFGLNAEQRKTYPLEDFEQMTELALNSHK-HGYLMNLMMIRF-PNF 241
            .|.::.:...|.:..:....||::.:.... |.:.|.:.|:..|..:. ..:::::.:..| ...
Human   169 PVTLKHVFGAYSMDVITSTSFGVSIDSLNN-PQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPI 232

  Fly   242 CRMLRMRRTPKQAEEYFIKLLTSIVEQR--ETSGKPQKDYLQLLIDVKALEFITHQYEADKELGA 304
            ...|.:...|::...:..|.:..|.|.|  ||. |.:.|:|||:||        .|...|.|...
Human   233 LEALNITVFPRKVISFLTKSVKQIKEGRLKETQ-KHRVDFLQLMID--------SQNSKDSETHK 288

  Fly   305 HLQN-ELAAHAVVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKS 368
            .|.: ||.|.:::|:.||||.|::.||:::||||.||::|.:|::|:...:. :....|::.:..
Human   289 ALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLP-NKAPPTYDTVLQ 352

  Fly   369 LSFMGQVINETLRMHPITPYILRRTLNDYAVPDH--PKYILVKELFLIIPTHAIHHDPDIYPDPE 431
            |.::..|:|||||:.|:...:.|....|..:...  ||.::|     :||::.:||||..:.:||
Human   353 LEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVV-----MIPSYVLHHDPKYWTEPE 412

  Fly   432 EFKPDRWSGPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFS--LNTRKPLIN 494
            :|.|:|:|.......:...:..||.|.|:|||::||.:.::|||..:|..:.|.  ..|:.||..
Human   413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKL 477

  Fly   495 LEDGIALTLMPLGVIEPGNEERAV 518
            ...|:.||..|:.:.....:|..|
Human   478 RFGGLLLTEKPIVLKAESRDETFV 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_611004.1	CYP6-like	74..509	CDD:410679	117/450 (26%)
CYP3A7-CYP3A51P	NP_001243426.2	CYP3A	67..492	CDD:410743	118/453 (26%)