DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp317a1 and Cyp3a41b

DIOPT Version :9

Sequence 1:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001098629.1	Gene:	Cyp3a41b / 100041375	MGIID:	3714859	Length:	504	Species:	Mus musculus

Alignment Length:	552	Identity:	140/552 - (25%)
Similarity:	254/552 - (46%)	Gaps:	101/552 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIIFLIIGLLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHYS 66
            |::..||       ||||..........::...||..:|   .|.:..::           .:|.
Mouse    12 WVLLAII-------LVLLYRYGTRTHGLFKKQGIPGPKP---LPFLGTVL-----------NYYK 55

  Fly    67 AIYK----KFKGSGPFCGFYALLQPRALILDRELIRQIMIKD----FWN---FNDRGLYCNQKSD 120
            .::|    .::..|...|.:....|..:|.|.|:|:.:::|:    |.|   |...|:.  .|:.
Mouse    56 GLWKFDMECYEKYGKTWGLFDGQMPLFVITDPEMIKNVLVKECFSVFTNRREFGPVGIM--SKAI 118

  Fly   121 PLSGDLYALRGESWKEMRQKLDPSLEGDRM-----------SLLYDCLYEEAEQLLLTVNSTLMS 174
            .:|.|      |.||..|..|.|:....::           .:|...|.:|||:          .
Mouse   119 SISKD------EEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEK----------G 167

  Fly   175 QPHSTVHIQKIMRRYVLSSLAKCVFGLNAEQRKTYPLEDFEQMTELALNSHKHGYLMNLMMIRFP 239
            :|   |.::.::..|.:..:....||:|.:.... |.:.|.:..:..|.......|: ..::.||
Mouse   168 KP---VTMKDVLGAYSIDVITSTSFGVNVDSLNN-PEDPFVEKAKGILRVDFFDPLV-FSVVLFP 227

  Fly   240 NFC---RMLRMRRTPKQAEEYFIKLLTSIVEQR-ETSGKPQKDYLQLLIDVKALEFITHQYEADK 300
            ...   .||.:...||.:.|:|.|.:..:.|.| ::..|.:.|:|||:::       .|....||
Mouse   228 FLTPVYEMLNICMFPKDSIEFFKKFVNRMKESRLDSKQKHRVDFLQLMMN-------AHNNSKDK 285

  Fly   301 ELGAHLQN-ELAAHAVVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHE 364
            :....|.: |:.|.::||:.||||.|::|||:.||.||.||::|.:::||:.:.:. :....|::
Mouse   286 DSHKALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLP-NKAPPTYD 349

  Fly   365 GIKSLSFMGQVINETLRMHPITPYILR-----RTLNDYAVPDHPKYILVKELFLIIPTHAIHHDP 424
            .:..:.::..|:|||||::||...:.|     ..||...:|        |...::||::|:||||
Mouse   350 TVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVELNGVYIP--------KGSTVMIPSYALHHDP 406

  Fly   425 DIYPDPEEFKPDRWSGPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFS---- 485
            ..:|:||||:|:|:|.......:...:..||:|.|:|||::||.:.::|||..::..:.|.
Mouse   407 QHWPEPEEFQPERFSKENKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQE 471

  Fly   486 -----LNTRKPLINLEDGIALTLMPLGVIEPG 512
                 ..:|:.|:..|..|.|.::|..|:..|
Mouse   472 TQIPLKLSRQGLLQPEKPIVLKVVPRDVVITG 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	117/458 (26%)
Cyp3a41b	NP_001098629.1	p450	39..494	CDD:278495	129/507 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820