Protein Alignment Cyp6a8 and CYP4F2

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Alignment Length: 454
• Identity: 115/454 - (25%)
• Similarity: 215/454 - (47%)
• Gaps: 47/454 - (10%)

  Fly    75 GFFFFQSPAAFVIDL---ELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLDGAQWRLLRNKL 136
            ||..:..|.:.::.|   ::.:.::....:.......||:..:..:...|....|.:|...|..|
Human    87 GFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRML 151

  Fly   137 SSTFTSGKMKLMYPTVVSVANEFMTVMHEK-----VPKNSVLEIRDLVARFTVDVIGTCAFGIQC 196
            :..|....:|    ..:.:.||.:.:||.|     ...::.|::.:.::..|:|.:..|.|...
Human   152 TPAFHFNILK----PYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFD- 211

  Fly   197 NSLRDEKAEFL--YFGKRSLVDKRHGTLLNGFMRSY------PKLARKLGMVR--TAPHIQEFYS 251
            :..:::.:|::  .....:||.|||..:|......|      .:..|...:|.  |...|||...
Human   212 SHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRR 276

  Fly   252 RIVTETV--AVREKEHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFET 314
            .:.::.|  .::.|...|..||:|:|:..|:      |:|   :.|:.|::.|:|..|...|.:|
Human   277 TLPSQGVDDFLQAKAKSKTLDFIDVLLLSKD------EDG---KKLSDEDIRAEADTFMFEGHDT 332

  Fly   315 SSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHD-QNFTYECTKDLKYLNQVLDETLRLYTIVPN 378
            ::|.:.:.||.|||:|:.|::.|.||:|:::..: :...::....|.:|...:.|:|||:..||.
Human   333 TASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPV 397

  Fly   379 LDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLP 443
            :.|...:..|:|  ...||..|...:|.....||:|:::|:|..:.|.||.||....|..:|::|
Human   398 ISRHVTQDIVLP--DGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIP 460

  Fly   444 FGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPK---SFVLGVKDGIYLKVE 504
            |..|||||||..|...:.::.|||.:..|:..       |...:|:   ..||..:.|::|:||
Human   461 FSAGPRNCIGQTFAMAEMKVVLALTLLRFRVL-------PDHTEPRRKPELVLRAEGGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	112/448 (25%)
CYP4F2	NP_001073.3	CYP4F	74..515	CDD:410772	112/450 (25%)