DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and CYP72A13

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_188084.1	Gene:	CYP72A13 / 820694	AraportID:	AT3G14660	Length:	512	Species:	Arabidopsis thaliana

Alignment Length:	528	Identity:	127/528 - (24%)
Similarity:	225/528 - (42%)	Gaps:	99/528 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALTYILFQVAVALLAILTYYIHRKL-----------TYFKRRGI------PFVAPHLIRGNMEE 48
            |.::.....|:||:: ::::::.|.|           :|.:|:|:      |.|..  ::.|...
plant     1 MEISVASVTVSVAVV-VVSWWVWRTLQRVWLKPKMLESYLRRQGLAGTPYTPLVGD--LKRNFSM 62

  Fly    49 L--QKTKNIH--------------EIFQDHYNKFRESKAPFVGFFFFQSPAAFVIDLELAKQILI 97
            |  .::|.|:              ::.:.|...|      |.  :|...|...::|.|..|::..
plant    63 LAEARSKPINLTDDITPRIVPYPLQMLKTHGRTF------FT--WFGPIPTITIMDPEQIKEVFN 119

  Fly    98 KDFSNFSNKGIFYNEKDDP----ISAHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANE 158
            |.: :|.....|      |    |:|.|.:.||.:|...|..::..|...|:|.|.|......:|
plant   120 KVY-DFQKAHTF------PLGRLIAAGLVSYDGDKWTKHRRIINPAFHLEKIKNMVPAFHQSCSE 177

  Fly   159 FMTVMHEKV-PKNSVLEIRDL---VARFTVDVIGTCAFGIQCN------SLRDEKAEFLYFGKRS 213
            .:....:.| .|.|..|: |:   :...|.|||...|||....      .|:.|.|:.:....|.
plant   178 IVGEWDKLVTDKQSSCEV-DIWPWLVSMTADVISRTAFGSSYKEGQRIFELQAELAQLIIQAFRK 241

  Fly   214 LVDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFYSRIVTETVAVREKEHIKRNDFMDMLIEL 278
                   .::.|: |.:|....: .|...|..|:.....||.:.:..||......:|.:.:|:|
plant   242 -------AIIPGY-RYFPTKGNR-RMKAAAREIKFILRGIVNKRLRAREAGEAPSDDLLGILLE- 296

  Fly   279 KNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEV 343
               ..:....|:   |::.||::.:..:|:.||.||::..:.:.:..|:::.|.|.:.|.||::|
plant   297 ---SNLGQTKGN---GMSTEELMEECKLFYFAGQETTTVLLVWTMVLLSQHQDWQARAREEVKQV 355

  Fly   344 IEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKR-----YVVPGHPNFVIEAGQSV 403
            .  .|:....|....||.:..:|.|.||||..|..|.|...|.     ..:||        |..:
plant   356 F--GDKEPDAEGLNQLKVMTMILYEVLRLYPPVVQLTRAIHKEMQLGDLTLPG--------GVQI 410

  Fly   404 IIPSSAIHHDPSIY-PEPFEFRPERFSPEES-AGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLA 466
            .:|...|..|..:: .:..||:|:||....| |.:..|::.||..|||.|||..|..::|::.:.
plant   411 SLPILLIQRDRELWGNDAGEFKPDRFKDGLSKATKNQVSFFPFAWGPRICIGQNFALLEAKMAMT 475

  Fly   467 LLIRNFKF 474
            |::|.|.|
plant   476 LILRKFSF 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	116/473 (25%)
CYP72A13	NP_188084.1	p450	24..512	CDD:299894	122/504 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810