Protein Alignment Cyp6a8 and Cyp4x1

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_001003947.1
• Gene: Cyp4x1 / 81906
• MGIID: 1932403
• Length: 507
• Species: Mus musculus
• Alignment Length: 546
• Identity: 141/546 - (25%)
• Similarity: 247/546 - (45%)
• Gaps: 108/546 - (19%)

  Fly     6 ILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAP--HLIRGNMEELQK--TKNIHEIFQDHYNKF 66
            ::|.:|:.|:..:..|:.|:  ...|...||..|  |.:.|:.:.||:  .:.:.||.:.|...|
Mouse    18 LVFCLALVLMQAMKLYLRRQ--RLLRDLSPFPGPPAHWLLGHQKFLQEDNMETLDEIVKKHPCAF 80

  Fly    67 RESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDP-ISAHLFNLDGAQWR 130
            .....||..||:...|       :.||..|    |....|..:.::...| |...|.||||.:|.
Mouse    81 PCWVGPFQAFFYIYDP-------DYAKIFL----SRTDPKMQYLHQLLTPCIGRGLLNLDGPRWF 134

  Fly   131 LLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPK-----NSVLEIRDLVARFTVDVIGTC 190
            ..|..|:..|....:|   |.|.::|:. :.||.:|..|     .:.:|:.:.:...|:|:|..|
Mouse   135 QHRCLLTPAFHQDILK---PCVDTMAHS-VKVMLDKWEKMWTTQETTIEVFEHINLMTLDIIMKC 195

  Fly   191 AFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGMV--------------- 240
            |||.:.|                       ..:||...||.|...:||.:
Mouse   196 AFGQETN-----------------------CQINGTYESYVKATFELGEIISSRLYNFWHHHDII 237

  Fly   241 -RTAPH----------IQEFYSRIVTETVAVREKEHIKRND------FMDMLIELKNQKEMTLEN 288
             :.:|.          |.::..:|:.:...:. |..:|::|      |:|:::..:.:.|....:
Mouse   238 FKLSPKGHCFQELGKVIHQYTEKIIQDRKKIL-KNQVKQDDTQTSQIFLDIVLSAQAEDERAFSD 301

  Fly   289 GDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTY 353
            .|         :.|:...|..||.:.|::::.:.||.||.||:.||:.|.|:..::.. ..:.|:
Mouse   302 AD---------LRAEVNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGD-GSSITW 356

  Fly   354 ECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVP-GHPNFVIEAGQSVIIPSSAIHHDPSIY 417
            |...::.|....:.|||||...||::.|..:|...:| ||.   :.||.:|::....:||:|:::
Mouse   357 EQLDEMSYTTMCIKETLRLIPPVPSISRELSKPLTLPDGHS---LPAGMTVVLSIWGLHHNPAVW 418

  Fly   418 PEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPN 482
            .:|..|.|.||:.|.|..|...|:|||..|||||||.:|..::.::.:||::.:|:.:
Mouse   419 NDPKVFDPLRFTKENSDQRHPCAFLPFSSGPRNCIGQQFAMLELKVAIALILLHFQVA------- 476

  Fly   483 PLVYDPKSF----VLGVKDGIYLKVE 504
            |.:..|.:|    ||..|.||||.::
Mouse   477 PDLTRPPAFSSHTVLRPKHGIYLHLK 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	121/472 (26%)
Cyp4x1	NP_001003947.1	CYP4B-like	66..500	CDD:410771	127/492 (26%)