DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a8 and TBXAS1

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001159725.2	Gene:	TBXAS1 / 6916	HGNCID:	11609	Length:	579	Species:	Homo sapiens

Alignment Length:	572	Identity:	151/572 - (26%)
Similarity:	264/572 - (46%)	Gaps:	93/572 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRESKAPFV 74
            ::|||||:|.:|.....:..::.|:....|....||:...::.      |.:...:.|:...|..
Human    20 LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQG------FWESQMELRKLYGPLC 78

  Fly    75 GFFFFQSPAAFVIDLELAKQILIKDFSNFSNK---GIFYNEKDDPISAHLFNLDGAQWRLLRNKL 136
            |::..:.....:.:.::.||:|:::||||:|:   |:.:....|.:   || |...:|..:|..|
Human    79 GYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSV---LF-LRDKRWEEVRGAL 139

  Fly   137 SSTFTSGKM----------------------------KLMYPTVVSVANEFMTVMHEKVP----- 168
            .|.|:..|:                            :|..|:.:.|...:.|:....||
Human   140 MSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMVPLISQA 204

  Fly   169 -------------KNSVLEIRDLVARFTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSL---VDK 217
                         .....:|:.....:|.||:.:.|||...:|.:..:..|:...||..   :.:
Human   205 CDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPR 269

  Fly   218 RHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFYSRIVTETVAVREKE--HIKRNDFMDMLIELKN 280
            ....||..|......|||.|.. :....:..|:::::...:|:|:::  ..:|.||:.|:::.::
Human   270 PILVLLLSFPSIMVPLARILPN-KNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARH 333

  Fly   281 Q-KEMTLENGDVVRG-----------------------LTMEEVLAQAFVFFIAGFETSSSTMGF 321
            . ..|.:::.|:||.                       ||::|::.|||:|.|||:|..::|:.|
Human   334 SASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSF 398

  Fly   322 ALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKR 386
            |.|.||.|||.|:|:..||:...|:|.........:.|.||:.|:.||||:|.......|.||:.
Human   399 ATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQD 463

  Fly   387 YVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNC 451
            ..|.|..   |.||..:.:...|:||||..:|.|..|.||||:.|.........:||||.|||:|
Human   464 CEVLGQR---IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC 525

  Fly   452 IGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKV 503
            :|:|.|.::.::.|..::..|:|..|.:|..||..:.|| .||.|:|:|:|:
Human   526 LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKS-ALGPKNGVYIKI 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	142/541 (26%)
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	142/543 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820