Protein Alignment Cyp6a8 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 151/572 - (26%)
• Similarity: 264/572 - (46%)
• Gaps: 93/572 - (16%)

  Fly    10 VAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRESKAPFV 74
            ::|||||:|.:|.....:..::.|:....|....||:...::.      |.:...:.|:...|..
Human    20 LSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQG------FWESQMELRKLYGPLC 78

  Fly    75 GFFFFQSPAAFVIDLELAKQILIKDFSNFSNK---GIFYNEKDDPISAHLFNLDGAQWRLLRNKL 136
            |::..:.....:.:.::.||:|:::||||:|:   |:.:....|.:   || |...:|..:|..|
Human    79 GYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSV---LF-LRDKRWEEVRGAL 139

  Fly   137 SSTFTSGKM----------------------------KLMYPTVVSVANEFMTVMHEKVP----- 168
            .|.|:..|:                            :|..|:.:.|...:.|:....||
Human   140 MSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMVPLISQA 204

  Fly   169 -------------KNSVLEIRDLVARFTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSL---VDK 217
                         .....:|:.....:|.||:.:.|||...:|.:..:..|:...||..   :.:
Human   205 CDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPR 269

  Fly   218 RHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFYSRIVTETVAVREKE--HIKRNDFMDMLIELKN 280
            ....||..|......|||.|.. :....:..|:::::...:|:|:::  ..:|.||:.|:::.::
Human   270 PILVLLLSFPSIMVPLARILPN-KNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARH 333

  Fly   281 Q-KEMTLENGDVVRG-----------------------LTMEEVLAQAFVFFIAGFETSSSTMGF 321
            . ..|.:::.|:||.                       ||::|::.|||:|.|||:|..::|:.|
Human   334 SASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSF 398

  Fly   322 ALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKR 386
            |.|.||.|||.|:|:..||:...|:|.........:.|.||:.|:.||||:|.......|.||:.
Human   399 ATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQD 463

  Fly   387 YVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNC 451
            ..|.|..   |.||..:.:...|:||||..:|.|..|.||||:.|.........:||||.|||:|
Human   464 CEVLGQR---IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSC 525

  Fly   452 IGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLKV 503
            :|:|.|.::.::.|..::..|:|..|.:|..||..:.|| .||.|:|:|:|:
Human   526 LGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKS-ALGPKNGVYIKI 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	136/507 (27%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	136/508 (27%)