Protein Alignment Cyp6a8 and Cyp4a31

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_964002.2
• Gene: Cyp4a31 / 666168
• MGIID: 3028580
• Length: 509
• Species: Mus musculus
• Alignment Length: 561
• Identity: 134/561 - (23%)
• Similarity: 228/561 - (40%)
• Gaps: 137/561 - (24%)

  Fly     7 LFQVAVALLAILTYYIHRKLTYFKRRGIP------FVAPHLIRGNMEELQKTKNIHEIFQDHYNK 65
            :|.:.:.|:..:..|:|||......:..|      |......:|: :|||:..:..|.|...:.:
Mouse    24 VFCLLLLLVKAVQVYLHRKWLLKALQQFPSPPFHWFFGHEQFKGD-QELQEIVSCIENFPSAFPR 87

  Fly    66 FRESKAPFVGFFFFQSPAAF-VIDLELAKQILIKDFSNFSNKGIFYNEKDDP------------I 117
                       :|:.|.|.. |.|.:..|.||               .:.||            |
Mouse    88 -----------WFWGSKAYLTVYDPDYMKVIL---------------GRSDPKANGAYRLLAPWI 126

  Fly   118 SAHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEK----VPKNSVLEIRDL 178
            ...|..|:|..|...|..|:..|....:|    |.|....:.:.:|.:|    ..::|.:||...
Mouse   127 GYGLLLLNGQSWFQHRKMLTPAFHYDILK----TYVKNMADSIRLMLDKWERLAGQDSSIEIFQH 187

  Fly   179 VARFTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSL-VDKRHGTL------LNGFMRSYPKLARK 236
            ::..|:|.:..|||.                .|.|: ||..:.|.      ||..:.|
Mouse   188 ISLMTLDTVMKCAFS----------------HKGSVQVDGNYKTYLQAIGDLNNLVHS------- 229

  Fly   237 LGMVRTAPHIQEFYSRIVTE-----------------TVAVR--------EKEHIK---RNDFMD 273
              .||...|..:...::.:.                 .:.:|        |.|:||   |.||:|
Mouse   230 --RVRNMFHQNDTIYKLSSNGRLSNQACQLAHDHTDGVIKMRKDQLQDEGELENIKKKRRLDFLD 292

  Fly   274 MLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRA 338
            :|:..:      :||.|   .::.:::.|:...|.|.|.:|::|.:.:..|.||.:|:.|.:.|.
Mouse   293 ILLFAR------MENED---SMSDKDLRAEVDTFMIEGHDTTASGVSWIFYALATHPEHQQRCRE 348

  Fly   339 EVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSV 403
            ||:.::.. ..:.|::....:.|....:.|.||||..||::.|..:.....|  ....:..|..|
Mouse   349 EVQSLLGD-GSSITWDHLDQIPYTTMCIKEALRLYPPVPSIGRELSTSVTFP--DGCSLPKGVQV 410

  Fly   404 IIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALL 468
            .:....:||:|.::|.|..|.|.||:|:  :.|.|.::|||..|.|||||.:|...:.::.:||.
Mouse   411 TLSIYGLHHNPKVWPNPEVFDPSRFAPD--SPRHSHSFLPFSGGARNCIGKQFAMSELKVIVALT 473

  Fly   469 IRNFKFSTCSKTPNPLVYDPKS---FVLGVKDGIYLKVETV 506
            :..|:.     .|:| ...|.|   |||..|:||||.::.|
Mouse   474 LLRFEL-----LPDP-TRVPMSLARFVLKSKNGIYLHLKKV 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	116/484 (24%)
Cyp4a31	NP_964002.2	CYP4B-like	71..504	CDD:410771	122/507 (24%)