Protein Alignment Cyp6a8 and CYP4F12

DIOPT Version :9

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 414
• Identity: 106/414 - (25%)
• Similarity: 202/414 - (48%)
• Gaps: 72/414 - (17%)

  Fly   126 GAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVM-----HEKVPKNSVLEIRDLVARFTVD 185
            |.:|...|..|:..|....:|    :.:::.|:...:|     |.....:|.|::.:.::..|:|
Human   141 GDKWSRHRRMLTPAFHFNILK----SYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLD 201

  Fly   186 VIGTCAFG----------------IQCNSLRDEKA-------EFLYF----GKRSLVDKRHGTLL 223
            .:..|.|.                ::.::|.::::       :|||:    |:|.   .|...|:
Human   202 SLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRF---HRACRLV 263

  Fly   224 NGFMRSYPKLARKLGMVRTAP--HIQEFYSRIVTETVAVREKEHIKRNDFMDMLIELKNQKEMTL 286
            :.|..:..:..|     ||.|  .|.:|:          ::|...|..||:|:|:..|:
Human   264 HDFTDAVIRERR-----RTLPTQGIDDFF----------KDKAKSKTLDFIDVLLLSKD------ 307

  Fly   287 ENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHD-QN 350
            |:|   :.|:.|::.|:|..|...|.:|::|.:.:.||.||::|:.|::.|.||:|:::..| :.
Human   308 EDG---KALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKE 369

  Fly   351 FTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPS 415
            ..::....|.:|...:.|:|||:...|.:.|...:..|:|  ...||..|.:.:|....:||:|:
Human   370 IEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLP--DGRVIPKGITCLIDIIGVHHNPT 432

  Fly   416 IYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKT 480
            ::|:|..:.|.||.||.|.||..:|::||..|||||||..|...:.::.|||::.:|:|......
Human   433 VWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTE 497

  Fly   481 PNPLVYDPKSFVLGVKDGIYLKVE 504
            |...:    ..::..:.|::|:||
Human   498 PRRKL----ELIMRAEGGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	104/411 (25%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	102/401 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810