Protein Alignment Cyp6a8 and CYP3A43

DIOPT Version :9

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 147/520 - (28%)
• Similarity: 253/520 - (48%)
• Gaps: 54/520 - (10%)

  Fly     4 TYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRE 68
            |::|...::.||.|...:.|:   .||:.|||...|....|.:  |...:.:....::...|:.|
Human    11 TWVLVATSLVLLYIYGTHSHK---LFKKLGIPGPTPLPFLGTI--LFYLRGLWNFDRECNEKYGE 70

  Fly    69 SKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNK------GIFYNEKDDPISAHLFNLDG 126
                ..|.:..|.|...::|.::.|.:|:|: :|.|:|:      |.        :.:.|...:.
Human    71 ----MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGF--------LKSALSFAED 123

  Fly   127 AQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCA 191
            .:|:.:|..||..|||.|.|.|.|.:....:..:..:.::...:..:.::|....:|:|||....
Human   124 EEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTL 188

  Fly   192 FGIQCNSLRDEKAEFLYFGKRSL-VDKRHGTLLNGFMRSYPKL-----ARKLGMVRTAPHIQEFY 250
            ||:..:||.:.:..||...|:.| :|.....||  .:..:|.|     |..:|:.  ...:..|.
Human   189 FGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLL--LISLFPFLTPVFEALNIGLF--PKDVTHFL 249

  Fly   251 SRIVTETVAVREKEHIK-RNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFET 314
            ...:......|.|:..| |.||...:|:.:|.||....     :.|:..|::||:.:...|.::|
Human   250 KNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSH-----KALSDLELVAQSIIIIFAAYDT 309

  Fly   315 SSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNL 379
            :|:|:.|.:||||.:||:|.|::.|::.|: .:....||:....::||:.|::|||||:.:|..:
Human   310 TSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRV 373

  Fly   380 DRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPE-RFSPEESAGRPSVAWLP 443
            .|:..|...:.|   ..|..|.:|::|..|:||||..:.||.:|.|| |||.:.........::|
Human   374 TRVCKKDIEING---VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIP 435

  Fly   444 FGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYD-------PKSFVLGV--KDGI 499
            ||.|||||||:||.....::.:...::||.|..|.:|..||..|       .|..||.|  :|||
Human   436 FGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGI 500

  Fly   500  499
            Human   501  500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	136/485 (28%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	133/481 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.720