Protein Alignment Cyp6a8 and Cyp3a57

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_001093650.1
• Gene: Cyp3a57 / 622127
• MGIID: 3646373
• Length: 503
• Species: Mus musculus
• Alignment Length: 511
• Identity: 136/511 - (26%)
• Similarity: 256/511 - (50%)
• Gaps: 52/511 - (10%)

  Fly     4 TYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRE 68
            |::|...::....|...|.|   ..||:.|||...|..:.||:  :.....:.:...|.|.|:
Mouse    11 TWVLLVTSLVFFYIYGTYSH---GLFKKLGIPGPKPLPLFGNI--INYLDGMWKFDDDCYKKY-- 68

  Fly    69 SKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNKGIF----YNEKDDPISAHLFNLDGAQ 128
              ....||:....|...::|.|:.|.:|:|: :|.|:|:..|    :.:|...||      :..:
Mouse    69 --GKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRPFGPVGFLKKSITIS------EDEE 125

  Fly   129 WRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAFG 193
            |:.||..||.||||.|:|.|:|.:....:..:..:..:..|...:.::|:...:::|||...:.|
Mouse   126 WKRLRTLLSPTFTSSKLKEMFPIMRQYGDILVRNLRREEEKEEPINMKDIFGAYSMDVITGTSCG 190

  Fly   194 IQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRS---YPKLARKLGMV-------RTAPHIQE 248
            :..:||.:.:..|:...|:.|..|    ..:.|:.|   :|.|.....|:       ::....::
Mouse   191 VNIDSLNNPQDPFVQKIKKILKFK----FFDPFLLSVVLFPFLTPIYEMLNLSIFPRQSMNFFKK 251

  Fly   249 FYSRIVTETVAVREKEHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFE 313
            |..::..:.:...:|..:   ||:.:::..:|.|     ..:.::.|:..|:.||..:|...|::
Mouse   252 FVKKMKKDRLDYNQKNRV---DFLQLMMNTQNSK-----GQESLKALSDLEMAAQTLIFIFGGYD 308

  Fly   314 TSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPN 378
            .:|:::.|.:||||.:||:|.|::.|::..: .:....||:...|::||:.|::|:||||.:|..
Mouse   309 GTSTSISFIMYELATHPDVQKKLQDEIDRAL-PNKAPVTYDALMDMEYLDMVVNESLRLYPVVSR 372

  Fly   379 LDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLP 443
            :||.:.|...:.|   ..|..|..|:||...:|.||..:|||.:|.|||||.|.........::|
Mouse   373 IDRFSKKDVEIHG---VFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPERFSKENKGNIDPYIYMP 434

  Fly   444 FGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPL------VYDPKSFVL 493
            ||:|||||||:||..:..::.:..:::||....|.:|..|:      ::.|:..::
Mouse   435 FGNGPRNCIGMRFALISVKLAVTGVLQNFTVQPCEETQIPVKISRQPIFRPEKPII 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	120/445 (27%)
Cyp3a57	NP_001093650.1	cytochrome_P450	67..492	CDD:477761	121/450 (27%)