DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a8 and Cyp4f1

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_062569.2	Gene:	Cyp4f1 / 56266	RGDID:	70926	Length:	524	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	139/545 - (25%)
Similarity:	235/545 - (43%)	Gaps:	92/545 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TYILFQVAVALLAILT--YYIHRKLTYFKR-RGIP-------------FVAPHLIRGNMEELQKT 52
            |.:||..:..|..|||  |..:|.   |:| ||.|             .|.|  ....::||.:.
  Rat    21 TLLLFGASWILAQILTQIYAAYRN---FRRLRGFPQPPKRNWLMGHVGMVTP--TEQGLKELTRL 80

  Fly    53 KNIHEIFQDHYNKFRESKAPFVGFFFFQSPAAFVIDL---ELAKQIL-------IKDFSNFSNKG 107
            ...:.                .||..:..|...||.|   ::.:.||       :||.
  Rat    81 VGTYP----------------QGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDV------- 122

  Fly   108 IFYNEKDDPISAHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPK--- 169
            |||......:...|....|.:|...|..|:..|....:|    ..|.:.|:...:||.|..:
  Rat   123 IFYTILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILK----PYVKIFNDSTNIMHAKWKRLIS 183

  Fly   170 --NSVLEIRDLVARFTVDVIGTCAFGIQCNSLRDEKAEFL--YFGKRSLVDKRHGTLLNGFMRSY 230
              :|.|::.:.|:..|:|.:..|.|....| .:::.:|::  .....:||.|||...|......|
  Rat   184 EGSSRLDMFEHVSLMTLDSLQKCVFSFDSN-CQEKSSEYIAAILELSALVAKRHQQPLLFMDLLY 247

  Fly   231 PKLARKLGMVRTAPHIQEFYSRIVTE---TVA-------VREKEHIKRNDFMDMLIELKNQKEMT 285
            ......:...:....:.||...::.|   |:.       ::.|...|..||:|:|:..|:
  Rat   248 NLTPDGMRFHKACNLVHEFTDAVIRERRRTLPDQGLDEFLKSKAKSKTLDFIDVLLLTKD----- 307

  Fly   286 LENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHD-Q 349
             |:|   :.|:.|::.|:|..|...|.:|::|.:.:.||.|||:|:.|::.|.||:|::...| :
  Rat   308 -EDG---KELSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRDPE 368

  Fly   350 NFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDP 414
            ...::....|.:|...:.|:|||:..|..:.|...:..::|  ....|..|...:|....|||:|
  Rat   369 EIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLP--DGRTIPKGIICLISIFGIHHNP 431

  Fly   415 SIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSK 479
            |::|:|..:.|.||.||.......:|::||..|||||||..|...:.::.|||.:..|:.....|
  Rat   432 SVWPDPEVYNPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPDDK 496

  Fly   480 TPNPLVYDPKSFVLGVKDGIYLKVE 504
            .|.   ..|: .:|..:.|::|:||
  Rat   497 EPR---RQPE-LILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	122/491 (25%)
Cyp4f1	NP_062569.2	CYP4F	74..515	CDD:410772	120/483 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900