DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	542	Identity:	152/542 - (28%)
Similarity:	248/542 - (45%)	Gaps:	90/542 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ILFQVAVALLAILTYYIHRKLTYF----KRRGIPFVA-PHLIRGNMEELQKTKNIHEIFQD---- 61
            |||...:.||...|.|...| .|.    :.|.||.:| .:.|.||  .||...|..:.|..
Zfish    12 ILFTAVLLLLLASTAYNPLK-NYIGKWNEMRPIPGMAGAYPIIGN--ALQFKTNAGDFFNQIIEG 73

  Fly    62 -HYNKFRESKAPFVGFFFFQSPAAFVIDLELAKQI-LIKDFSNFSNKGIFYNEKDDPISAHLFNL 124
             :.|:.......:||      |..|:| |..|:.| ::...|...:|...|......:...|...
Zfish    74 TNENRHLPLAKVWVG------PVPFLI-LYHAENIEVVLSNSRHLDKSYSYRFLHPWLGTGLLTS 131

  Fly   125 DGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEK----VPKNSVLEIRDLVARFTVD 185
            .|.:||..|..|:.||.           .|:.::|:.||:|:    :.|...||..:....|  :
Zfish   132 TGEKWRNRRKMLTPTFH-----------FSILSDFLEVMNEQTDILIQKMQKLEDGEPFNCF--N 183

  Fly   186 VIGTCAFGIQCNSLRDEK--------AEFL--YFGKRSLVDKRHGTLLNGFMRS--------YPK 232
            .|..||..|.|.:...:|        :|::  .:....::.||        .|:        |.|
Zfish   184 FITLCALDIICETAMGKKIYAQSNADSEYVQSVYKMSDIITKR--------QRAPWLWPDWIYNK 240

  Fly   233 L------ARKLGMVR--TAPHIQEFYSRIVTETVAVREKEHIKRNDFMDMLIELKNQKEMTLENG 289
            |      |::|.::.  ||..|:|....:.:|..:..::...||..|:|||:      :.|.|||
Zfish   241 LKEGKEHAKRLKILHSFTANVIRERAEFMSSEPDSDSDQGERKRQAFLDMLL------KTTYENG 299

  Fly   290 DVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYE 354
               :.|:.|::..:...|...|.:|::::|.:||:.:..:|::|..|:||::||....:::...|
Zfish   300 ---QKLSHEDIQEEVDTFMFEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFGSSERHVGVE 361

  Fly   355 CTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPE 419
            ..|.|:||..|:.|:||::..||...|...:...:.|   |.:..|.:.:|...|:|.||..:||
Zfish   362 DLKKLRYLECVIKESLRIFPSVPLFARSICEACHING---FKVPKGVNAVIIPYALHRDPRYFPE 423

  Fly   420 PFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTP--N 482
            |.||:||||.||.|.||...|::||..|||||||.||..|:.::.||.::|:|....|....  .
Zfish   424 PEEFQPERFMPENSKGRHPYAYIPFSAGPRNCIGQRFAMMEEKVVLATILRHFDVEACQSREELR 488

  Fly   483 PLVYDPKSFVLGVKDGIYLKVE 504
            ||    ...:|..:.||::|::
Zfish   489 PL----GELILRPEKGIWIKLQ 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	138/501 (28%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	140/506 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810