DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and cyp3c2

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	XP_021330384.1	Gene:	cyp3c2 / 558473	ZFINID:	ZDB-GENE-081103-62	Length:	503	Species:	Danio rerio

Alignment Length:	510	Identity:	149/510 - (29%)
Similarity:	262/510 - (51%)	Gaps:	48/510 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALTYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNK 65
            :::|:||..:.:.||.:...:.|   .:||:.|||...|....|..  |..||.......:...|
Zfish     7 LSVTWILVVLVLTLLYMYGVWPH---GFFKKLGIPGPRPWPFFGTF--LSYTKGFFNFDMECAKK 66

  Fly    66 FRESKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNKGIFYNEKDDPISAHLFNLDGAQW 129
            :    ....|.:..:.|...|.|||:.|.|::|: :|.|:|:.....:...|::..:..:...:|
Zfish    67 Y----GKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREINVDLAGPLADGITAVKDERW 127

  Fly   130 RLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAFGI 194
            :.:|..||..||||::|.::|..::.|:.|:..| :|......::|::::|.:::||:.:.||.:
Zfish   128 KRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNM-QKGDHEQPVKIKEVMASYSLDVVTSSAFSV 191

  Fly   195 QCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGMVR----TAPHIQEFYSRIVT 255
            ..:|:.:....|:...|..|.....| |....:..:|.:|..||.:.    :.|.:..||..:
Zfish   192 DIDSINNPDDPFVTNIKNFLKFNLFG-LFVLLLTVFPSIANLLGKMGLSMFSKPTVDFFYKAL-- 253

  Fly   256 ETVAVREKEHIKRNDFMDMLIELKNQ------KEMTLENGDVVRGLTMEEVLAQAFVFFIAGFET 314
            ..:....|:...|.||..::|:  |:      |:.|.|..:  :|||..|:|:|:|:|.:.|:||
Zfish   254 RKIKEEHKDSNGRVDFFRLMIQ--NEIPDDQVKDTTSEQPE--KGLTDHEILSQSFIFIMGGYET 314

  Fly   315 SSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNF------TYECTKDLKYLNQVLDETLRLY 373
            :|:|:.|.||.||.|||.       :|:::|:.|:||      :|:....:.||...::|::||.
Zfish   315 TSTTLTFLLYNLAINPDC-------LEKLVEKIDKNFPLDTPISYDALMKIDYLEMSINESMRLL 372

  Fly   374 TIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPS 438
            ...|.|:|:..|...:.|   ..|.....:.||:..::.||.::..|.||||||||||..:....
Zfish   373 PTAPRLERVCKKTVEMNG---ITIPKDTMITIPTYVLNQDPQLWDSPHEFRPERFSPENKSEFLQ 434

  Fly   439 VAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPL----VYDPK 489
            .|::|||.|||||||:|:..|..::.:..|::||...||.:|..||    |:.||
Zfish   435 YAFMPFGLGPRNCIGMRYALMIVKLLVVKLLQNFSVETCKETQIPLELNPVFQPK 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	138/472 (29%)
cyp3c2	XP_021330384.1	p450	38..496	CDD:306555	139/476 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910