DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	532	Identity:	152/532 - (28%)
Similarity:	257/532 - (48%)	Gaps:	65/532 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ALTYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIR--GNMEELQKTKNIHEIFQDHYN 64
            |.|:.|.....|||.|...:.||   |||:.|||  .|..|.  |.|  |:.....|....|.:.
Zfish     5 AETWTLLAFLAALLVIYGSWPHR---YFKKLGIP--GPKAIPFFGTM--LRYKDGFHVFDMDCFE 62

  Fly    65 KFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNK------GIFYN-----EKDDPI 117
            |:    ....|.:..:.|...::|..:.|.:|||: :|.|:|:      |..|:     |.||
Zfish    63 KY----GRIWGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRRNFRLNGALYDAVSIAEDDD-- 121

  Fly   118 SAHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARF 182
                       ||.:|:.||.:||||::|.|:..:...::..:..|.:...:....:|::....:
Zfish   122 -----------WRRIRSVLSPSFTSGRLKEMFGIMKKHSHILVDSMGKTAKRGESADIKEFFGAY 175

  Fly   183 TVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNG---FMRSYPKLA---RKLGMVR 241
            ::||:.:.||.:..:||.:.|..|:...|:.|    ...|||.   .:..:|.:|   .|:....
Zfish   176 SMDVVTSTAFSVDIDSLNNPKDPFVTNIKKML----KFDLLNPLFLLIAFFPFMAPVLEKMDFAL 236

  Fly   242 TAPHIQEFYSRIV--------TETVAVREKEHI-KRNDFMDMLIELKNQKEMTLENGDVVRGLTM 297
            ....:.:|:...:        |:|||   |::. ||.||:.::::.:...:...:.....:||:.
Zfish   237 FPTSVTDFFYAALQKIKSDRDTKTVA---KDNTKKRVDFLQLMVDSQTGVKHKSDGEHTEKGLSD 298

  Fly   298 EEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYL 362
            .|:|:|:.:|..||:||||||:.|..|.||.||:...|::.|::|.. .:.....||....:.||
Zfish   299 HEILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETF-PNQAPVDYETLMSMDYL 362

  Fly   363 NQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPER 427
            :..|.|:|||:.:...|:|:..|...:.|   .:|.....|::|:.|:|.||..:.||..|:|||
Zfish   363 DAALSESLRLFPVAARLERVCKKTVEING---LLIPKDLVVMVPTYALHRDPDYWSEPESFKPER 424

  Fly   428 FSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFV 492
            |:...........::|||.|||||||:||.|:..::.:..:::.|..|.|.:|..||...... :
Zfish   425 FTKGNKESIDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLELGFNG-L 488

  Fly   493 LGVKDGIYLKVE 504
            |..||.|.||::
Zfish   489 LSPKDPIKLKLQ 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	136/492 (28%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	137/496 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8421
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.820