Protein Alignment Cyp6a8 and Cyp4a1

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_787031.1
• Gene: Cyp4a1 / 50549
• RGDID: 68945
• Length: 509
• Species: Rattus norvegicus
• Alignment Length: 547
• Identity: 138/547 - (25%)
• Similarity: 235/547 - (42%)
• Gaps: 117/547 - (21%)

  Fly     9 QVA--VALLAILT----YYIHRK--LTYFKRRGIPFVAP--HLIRGNME-----ELQKTKNIHEI 58
            |||  :.||.:|.    :|:.|:  |..|::    |.:|  |...|:.:     |||:.....|.
  Rat    20 QVASVLGLLLLLVKAVQFYLQRQWLLKAFQQ----FPSPPFHWFFGHKQFQGDKELQQIMTCVEN 80

  Fly    59 FQDHYNK-FRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLF 122
            |...:.: |..|||..:           |.|.:..|.||.:  |:....|: |......|...|.
  Rat    81 FPSAFPRWFWGSKAYLI-----------VYDPDYMKVILGR--SDPKANGV-YRLLAPWIGYGLL 131

  Fly   123 NLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVM---HEKVPKNSVLEIRDLVARFTV 184
            .|:|..|...|..|:..|   ...::.|.|.::|:....::   .:...::|.:||...::..|:
  Rat   132 LLNGQPWFQHRRMLTPAF---HYDILKPYVKNMADSIRLMLDKWEQLAGQDSSIEIFQHISLMTL 193

  Fly   185 DVIGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTL-LNGFMRSYPKLARKL-----GMVRTA 243
            |.:..|||                        ..:|:: ::|..:||.:....|     ..||..
  Rat   194 DTVMKCAF------------------------SHNGSVQVDGNYKSYIQAIGNLNDLFHSRVRNI 234

  Fly   244 PH----IQEF------YSRIV------TETVAVREKEHI------------KRNDFMDMLIELKN 280
            .|    |..|      ::|..      |:.|....|:.:            :|.||:|:|:..:
  Rat   235 FHQNDTIYNFSSNGHLFNRACQLAHDHTDGVIKLRKDQLQNAGELEKVKKKRRLDFLDILLLAR- 298

  Fly   281 QKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIE 345
                 :||||   .|:.:::.|:...|...|.:|::|.:.:..|.||.:|:.|.:.|.||:.|:.
  Rat   299 -----MENGD---SLSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSVLG 355

  Fly   346 QHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAI 410
            . ..:.|::....:.|....:.|.||||..||.:.|..:.....|...:  :..|..|.:....:
  Rat   356 D-GSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRS--LPKGIQVTLSIYGL 417

  Fly   411 HHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFK-F 474
            ||:|.::|.|..|.|.||:|:  :.|.|.::|||..|.|||||.:|...:.::.:||.:..|: .
  Rat   418 HHNPKVWPNPEVFDPSRFAPD--SPRHSHSFLPFSGGARNCIGKQFAMSEMKVIVALTLLRFELL 480

  Fly   475 STCSKTPNPLVYDPKSFVLGVKDGIYL 501
            ...:|.|.||   |: .||..|:||||
  Rat   481 PDPTKVPIPL---PR-LVLKSKNGIYL 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	114/467 (24%)
Cyp4a1	NP_787031.1	CYP4B-like	71..504	CDD:410771	123/492 (25%)