Protein Alignment Cyp6a8 and Cyp3a73

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: XP_038945885.1
• Gene: Cyp3a73 / 498198
• RGDID: 1595705
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 521
• Identity: 156/521 - (29%)
• Similarity: 252/521 - (48%)
• Gaps: 71/521 - (13%)

  Fly    14 LLAILTYYIHRKLT----YFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRESKAPFV 74
            ||||:....:|..|    .||::|||...|....|.:  |...:.:.:...:.|.|.    ....
  Rat    14 LLAIILVLFYRFGTRTHGIFKKQGIPGPKPLPFLGTV--LNYYRGLWKFDMECYKKC----GKIW 72

  Fly    75 GFFFFQSPAAFVIDLELAKQILIKD-FSNFSNK------GIFYNE----KDDPISAHLFNLDGAQ 128
            |.|..|:|...::|.|:.|.:|:|: ||.|:|:      ||....    ||:            :
  Rat    73 GLFDGQTPVFAIMDTEMIKSVLVKECFSVFTNRRNIGPVGIMSKSISVAKDE------------E 125

  Fly   129 WRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAFG 193
            |:..|..||.|||||::|.|:|.:....:..:..:.:||.|...|.::::...:::|||.:.:|.
  Rat   126 WKRYRAFLSPTFTSGRLKEMFPIIEHYGDILVKYLKQKVEKGKPLAMKEVFGAYSMDVITSTSFE 190

  Fly   194 IQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMR------------SYPKLARKLGMVRTAPHI 246
            :..||:.:.|..|        |:|     :..|.|            .:|.|.....|:......
  Rat   191 VNINSINNPKDPF--------VEK-----VKKFQRFDFFDPLFLSVVLFPFLTPIYEMLNICLFP 242

  Fly   247 QE---FYSRIVTETVAVR-EKEHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVF 307
            ::   |:.:.|......| :.:|..|.||:.:::...|..:..:.:    :.|:..|::|||.:|
  Rat   243 KDSVAFFQKFVYRMKQTRLDSKHKHRVDFLQLMMNAHNNSKDKVSH----KALSDIEIVAQAIIF 303

  Fly   308 FIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRL 372
            ..|.:||:|||:.|.||.||.:||.|.|::.|::..:...... ||:...:::||:.||:||.||
  Rat   304 IFASYETTSSTLSFVLYSLATHPDSQKKLQEEIDRALPNKAPP-TYDTVMEMEYLDMVLNETPRL 367

  Fly   373 YTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRP 437
            |.|...|:|:..|...:.|   ..|..|..|:||...:.|||..:|||.||.|||||.|......
  Rat   368 YPIGYRLERVCKKDIKLDG---VFIPKGSVVMIPFYTLQHDPQHWPEPEEFLPERFSKENKGSID 429

  Fly   438 SVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLK 502
            ...:||||:|||||||:||..|..::.|..:::||.|..|.:|..||... :..:.|.:..|.||
  Rat   430 PYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQLCEETQIPLKLS-RQRLFGPEKPIVLK 493

  Fly   503 V 503
            |
  Rat   494 V 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	136/456 (30%)
Cyp3a73	XP_038945885.1	CYP3A	67..493	CDD:410743	138/463 (30%)