DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	509	Identity:	150/509 - (29%)
Similarity:	264/509 - (51%)	Gaps:	46/509 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALTYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNK 65
            :::|:.|..:.:.||.:...:.|   .:||:.|||...|....|..  |..||.......:...|
Zfish     7 LSVTWTLVFLVITLLYMYGVWPH---GFFKKLGIPGPRPWPFFGTF--LSYTKGFFNFDMECAKK 66

  Fly    66 FRESKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNKGIFYNEKDDPISAHLFNLDGAQW 129
            :    ....|.:..:.|...|.|||:.|.|::|: :|.|:|:.....:...|::..:..:...:|
Zfish    67 Y----GKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADGISAVKDERW 127

  Fly   130 RLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAFGI 194
            :.:|..||..||||::|.::|..::.|:.|:..|.::..:..| :|:::||.:::||:.:.:|.:
Zfish   128 KRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKRDHEQPV-KIKEVVAPYSLDVVTSSSFSV 191

  Fly   195 QCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFYSRIVTETVA 259
            ..:|:.:....|:...|..|.......|:. |:..:|.:|..||.:..:...:...:...|....
Zfish   192 DIDSINNPDDPFVTNIKNFLKFSLFSPLIL-FLTLFPSIANLLGKMGISVFSRSIMNFFYTALRK 255

  Fly   260 VREKEHIKRN---DFMDMLIELKNQ------KEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETS 315
            ::: ||...|   ||:.::|:  ||      |:.|.|  ..|:|||..|:|:|:|:|.:.|:||:
Zfish   256 IKD-EHKDSNGRVDFLRLMIQ--NQIPDDQAKDTTSE--QPVKGLTDHEILSQSFIFILGGYETT 315

  Fly   316 SSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNF------TYECTKDLKYLNQVLDETLRLYT 374
            |:|:.|.|:.||.|||.       :|:::|:.|:||      :|:....:.||...::|::||..
Zfish   316 STTLSFLLHNLATNPDC-------LEKLVEEIDKNFPLDTPISYDALMKMDYLEMSINESMRLLP 373

  Fly   375 IVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSV 439
            ..|.|:|:..|...:.|   ..|.....|.||:..::.||.::..|.||||||||||..:.....
Zfish   374 TAPRLERVCKKTVELNG---ITIPKDTLVAIPTYVLNRDPQLWDSPQEFRPERFSPENKSEFLQY 435

  Fly   440 AWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPL----VYDPK 489
            |::|||.|||||||:||..|..::.:..|::||...||.:|..||    |:.||
Zfish   436 AFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKETQIPLELTPVFQPK 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	140/471 (30%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	141/475 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8421
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.720