Protein Alignment Cyp6a8 and LOC4577431

DIOPT Version :10

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: XP_001237417.1
• Gene: LOC4577431 / 4577431
• VectorBaseID: AGAMI1_011574
• Length: 462
• Species: Anopheles gambiae
• Alignment Length: 512
• Identity: 122/512 - (23%)
• Similarity: 197/512 - (38%)
• Gaps: 105/512 - (20%)

  Fly     8 FQVAVALLAILTYYIHRKLTYFKRRGI------PFVA-PHLIRGNMEELQKTKNIHEIF--QDHY 63
            |.:|:....:||......|...|||.:      |... ..::.|:.....:|:  |.|:  |..|
Mosquito     6 FWIALGTTVLLTGAFGLCLILDKRRSLWVDRRFPSTGRTCVLYGDYGAAGRTE--HRIYTTQRLY 68

  Fly    64 NKFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLDGAQ 128
            .:|:..|.|..|...:.:|.....|..|.:.:|.::|..        |:|.....:.:|.   .:
Mosquito    69 REFKSKKWPIGGALMYLTPCVIPTDPHLIEFLLNEEFGK--------NKKSSIAGSSIFR---KR 122

  Fly   129 WRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKV-----PKNSVLEIRDLVARFTVDVIG 188
            |        |:|....    |.::|:||.|    ..|||     .....::::.:...:.|.:|.
Mosquito   123 W--------SSFEDEH----YNSLVNVATE----ESEKVVEMLCTSKQPVDVKVIAELYAVRMIA 171

  Fly   189 TCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQ------ 247
            .|.||.:|.   :|...|....|  |..:..|.:.:.|..::|.......:.:...|.|
Mosquito   172 RCVFGKRCT---EESHTFPITEK--LASQPGGIVWDVFSTAFPSTTFTATLRKLLDHFQKHPALL 231

  Fly   248 -EFYSRIVTE-TVAVREKEHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIA 310
             |..|..:|| |..|...:|:||.       |.:.:....:..|| .|.|.:|  |.|. |||:|
Mosquito   232 DELVSSFLTERTADVNFLQHLKRT-------EQRAKANERIAFGD-TRALMLE--LVQN-VFFVA 285

  Fly   311 GFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTI 375
                 |.|:...|:|:..|.|||..:...:     |....|..:.      |..|:.||||.|..
Mosquito   286 -----SGTIIACLFEMGHNGDIQKGLHETL-----QRSNPFAVDT------LENVISETLRKYPP 334

  Fly   376 VPNL-------DRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPER--FSPE 431
            |..:       :|:.:...|||.:..        |::|..|:.||...||:|..|.|:|  ||..
Mosquito   335 VGEISFVTVANNRLPSGELVVPKNTR--------VVVPIYALQHDAEHYPDPERFNPKRSIFSSS 391

  Fly   432 ESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDP 488
            |.    ||.:.|.|..|.. ||.....:..|:.|:.::.........::|..|...|
Mosquito   392 EQ----SVLYRPLGVQPLP-IGSSLALLMVRVALSNILGRCTVRLTPESPATLKISP 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	CYP6-like	70..500	CDD:410679	106/441 (24%)
LOC4577431	XP_001237417.1	cytochrome_P450	74..454	CDD:477761	106/442 (24%)