DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a8 and Cyp4e1

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	128/572 - (22%)
Similarity:	251/572 - (43%)	Gaps:	122/572 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YILFQVAVAL-LAILTYY----IHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKN---------I 55
            :|:....:|| |.::||:    :.||....|.:| |.:.|  :.||..::..|..         .
  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQG-PSMLP--LVGNAHQMGNTPTEILNRFFGWW 63

  Fly    56 HEIFQDHYNKFRESKAPFVGFF---FFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPI 117
            ||..:|::..       ::|::   ...:|.  .::..|:.|.||       :|...|:.....:
  Fly    64 HEYGKDNFRY-------WIGYYSNIMVTNPK--YMEFILSSQTLI-------SKSDVYDLTHPWL 112

  Fly   118 SAHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPK-----------NS 171
            ...|....|::|...|..::..|.           .::..:|..||:|...|           .:
  Fly   113 GLGLLTSTGSKWHKHRKMITPAFH-----------FNILQDFHEVMNENSTKFIDQLKKVADGGN 166

  Fly   172 VLEIRDLVARFTVDVIGTCAFGIQCNSLRDEKAEFLYFGK--------RSLVDKRHGTLLNGFMR 228
            :.:.::.....|:|||...|.|:..|::.:..:..:...|        |:....:....|..|..
  Fly   167 IFDFQEEAHYLTLDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAP 231

  Fly   229 SYPKLARKLGMVRTAPHIQEFYSRIVTETVAVRE---KEHIKRNDFMDMLIELKNQKEM----TL 286
            .||:.:      :|...:|:|.:.|:.:.:.||:   :..||.::|        ::|:|    ||
  Fly   232 EYPEYS------KTLKTLQDFTNEIIAKRIEVRKSGLEVGIKADEF--------SRKKMAFLDTL 282

  Fly   287 ENGDV-VRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQH--D 348
            .:..| .|.||.:|:..:...|...|.:|::|.:|||:|.|:::||.|:|:..|..:|:...  .
  Fly   283 LSSKVDGRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLG 347

  Fly   349 QNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHD 413
            ::.|::....:|:|:..:.|..|||..||.:.|...|.||:.|.   ::..|.::.:....:.::
  Fly   348 RDATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVIDGD---IVPKGTTLNLGLLMLGYN 409

  Fly   414 PSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFK----- 473
            ..::.:|.:|:||||..|:..   ...::||..|||||||.:|..::.:..::.:||||:
  Fly   410 DRVFKDPHKFQPERFDREKPG---PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPAL 471

  Fly   474 ---------FSTC---------SKTPNPLVYDP---KSFVLGVKDGIYLKVE 504
                     .||.         |:..:...|||   .|..|..::|::|:::
  Fly   472 DELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPILSASMTLKSENGLHLRMK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	117/530 (22%)
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	109/484 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810