DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a8 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	169/521 - (32%)
Similarity:	265/521 - (50%)	Gaps:	36/521 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YILFQVAVALLAILTY-YIHRKLTYFKRRGIPFVAPHLIRGNMEEL-QKTKNIHEIFQDHYNKFR 67
            :.||.:|.||.    | :......:||.|||.:..|.|..|||..: .:.:.:.:|..|.|.|..
  Fly     6 FALFAIAAALF----YRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYTKGG 66

  Fly    68 ESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSN-KGIFYNEKDDP-------ISAHLFNL 124
            ..|  |.|.|..:.|...|.|.:|.|||.||||.:|.| :.:|....||.       ..:.||::
  Fly    67 SKK--FFGIFEQRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLFGSSLFSM 129

  Fly   125 DGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHE---KVPKNSVLEIRDLVARFTVDV 186
            ..|:|:.:|:.||..||..||:.|:..:..||.|.:..:.:   :|.:|. |:::|...|||.||
  Fly   130 RDARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENE-LDMKDYCTRFTNDV 193

  Fly   187 IGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNG--FMRSYP-KLARKLGMVRTAPH-IQ 247
            |.:.|||:|.||.:|.:..|...||:...    .|.|..  ||..:. |...|:..|..... ..
  Fly   194 IASTAFGLQVNSFKDRENTFYQMGKKLTT----FTFLQSMKFMLFFALKGLNKILKVELFDRKST 254

  Fly   248 EFYSRIVTETVAVREKEHIKRNDFMDMLIELKN--QKEMTLENGDVVRGLTMEEVLAQAFVFFIA 310
            :::.|:|.:.:..|::.:|.|.|.::||:|.:.  |.|.|  ....||..:..:::||.||||.|
  Fly   255 QYFVRLVLDAMKYRQEHNIVRPDMINMLMEARGIIQTEKT--KASAVREWSDRDIVAQCFVFFFA 317

  Fly   311 GFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQ-HDQNFTYECTKDLKYLNQVLDETLRLYT 374
            |||||:..|.|..:||.:|.|:|.::..||::|.:. ..:..|||....:|||:||::|.||.:.
  Fly   318 GFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGKELTYEAIMGMKYLDQVVNEVLRKWP 382

  Fly   375 IVPNLDRMAAK--RYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRP 437
            ....:||...|  .:.|.|. ...::.|..:.:|:...|.||..:..|.:|.|||||.|......
  Fly   383 AAIAVDRECNKDITFDVDGQ-KVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQ 446

  Fly   438 SVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLK 502
            ...:.|||.|.|||||.||..::|:..:..|:::::|:...|:..||......|.|..|.|.::|
  Fly   447 PFTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWIK 511

  Fly   503 V 503
            :
  Fly   512 L 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	157/484 (32%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	157/483 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461235
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800