Protein Alignment Cyp6a8 and CYP4F3

DIOPT Version :9

• Sequence 1: NP_523749.2
• Gene: Cyp6a8 / 36666
• FlyBaseID: FBgn0013772
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 418
• Identity: 110/418 - (26%)
• Similarity: 200/418 - (47%)
• Gaps: 44/418 - (10%)

  Fly   108 IFYNEKDDPISAHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEK----VP 168
            :||:.....:...|....|.:|...|..|:..|....:|    ..:.:.||.:.:||.|    ..
Human   123 VFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILK----PYMKIFNESVNIMHAKWQLLAS 183

  Fly   169 KNSV-LEIRDLVARFTVDVIGTCAFGIQCNSLRDEKAEFL--YFGKRSLVDKRHGTLLNGFMRSY 230
            :.|. |::.:.::..|:|.:..|.|... :..:::.:|::  .....:||.|||..:|......|
Human   184 EGSARLDMFEHISLMTLDSLQKCVFSFD-SHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLY 247

  Fly   231 ------PKLARKLGMVR--TAPHIQEFYSRIVTETV--AVREKEHIKRNDFMDMLIELKNQKEMT 285
                  .:..|...:|.  |...|||....:.::.|  .::.|...|..||:|:|:..|:
Human   248 YLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKD----- 307

  Fly   286 LENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHD-Q 349
             |:|   :.|:.|::.|:|..|...|.:|::|.:.:.||.|||:|:.|::.|.||:|:::..: :
Human   308 -EDG---KKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPK 368

  Fly   350 NFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDP 414
            ...::....|.:|...:.|:|||:..||.:.|...:..|:|  ...||..|...:|.....||:|
Human   369 EIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLP--DGRVIPKGIICLISVFGTHHNP 431

  Fly   415 SIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSK 479
            :::|:|..:.|.||.|:....|..:|::||..|||||||..|...:.::.|.|.:..|:..
Human   432 AVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVL---- 492

  Fly   480 TPNPLVYDPK---SFVLGVKDGIYLKVE 504
               |...:|:   ..||..:.|::|:||
Human   493 ---PDHTEPRRKPELVLRAEGGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	108/415 (26%)
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	107/414 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810