DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a8 and cyp4t8

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_954686.2	Gene:	cyp4t8 / 387527	ZFINID:	ZDB-GENE-031219-3	Length:	509	Species:	Danio rerio

Alignment Length:	546	Identity:	130/546 - (23%)
Similarity:	235/546 - (43%)	Gaps:	107/546 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AVALLAILTYYIHRKLTYFKRRGIP----FVAP--HLIRGNMEE-------LQKTKNIHEIFQDH 62
            |:..||.|...:  ||...:|:|:.    |..|  |.:.|:::|       |:|.....|::|
Zfish    18 ALIFLACLLTVV--KLLIVRRKGVKTMERFPGPPAHWLFGHVKEFRQDGHDLEKIVKWMELYQ-- 78

  Fly    63 YNKFRESKAPFVGFFFFQSPAAFVIDL---ELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNL 124
                       ..|..:..|:..|:::   ...|.||...           ..|||  .|:.|.:
Zfish    79 -----------FAFPLWFGPSLAVLNIHHPSYVKTILTTT-----------EPKDD--YAYKFFI 119

  Fly   125 ----------DGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMT---VMHEKVPKNSVLEIR 176
                      .|.:|...|..|:..|....:| .|..::|.:.:.|.   .:|.:..::  .|:.
Zfish   120 PWLGDGLLVSTGQKWFRHRRLLTPGFHYDVLK-PYVKLISDSTKVMLDKWEVHSRSEES--FELF 181

  Fly   177 DLVARFTVDVIGTCAFGIQCNS-LRDEKAEFLYFGKRSLVDKRHGTLLNGFMRSYPKLARKLGMV 240
            ..|:..|:|.|..|||  .||| .:.:.....|.  :::.|..|  |:|...|.:|..::  .:.
Zfish   182 KHVSLMTLDSIMKCAF--SCNSNCQTDSGTNPYI--QAVFDLCH--LVNLRFRVFPYHSK--AIF 238

  Fly   241 RTAPHIQEFYS-------------RIVTETVAVREKEHIKRN----DFMDMLIELKNQKEMTLEN 288
            ..:||...|..             |...|.:.:.|::.|.:|    ||:|:|:..:::.:
Zfish   239 HLSPHGYRFRKAASIAHNHTAEVIRKRKEVLKMEEEQGIVKNRRYLDFLDILLSARDEHQ----- 298

  Fly   289 GDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTY 353
                :||:.|::.|:...|...|.:|::|.:.:..|.||.||:.|:|.|.|:::.:: ......:
Zfish   299 ----QGLSDEDIRAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCRQEIQQALD-GKATLEW 358

  Fly   354 ECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYP 418
            |....:.|....:.|:|||:..||.:.|...|....  .....:..|.::.:....||.:.:::.
Zfish   359 EDLNKIPYTTMCIKESLRLHPPVPGISRKLTKPLTF--FDGRTVPEGCTIGVSIYGIHMNSTVWE 421

  Fly   419 EPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNP 483
            .|::|.|.||.||..|.|...|::||..|||||||..|...:.::.:||.::.:..   .|.|:
Zfish   422 NPYKFDPLRFLPENVANRSPHAFVPFSAGPRNCIGQNFAMNEMKVAVALTLKRYYL---IKDPD- 482

  Fly   484 LVYDPK---SFVLGVKDGIYLKVETV 506
              :.||   ..||...:||::|::.|
Zfish   483 --HTPKMIPQVVLRSLNGIHIKIKPV 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	119/509 (23%)
cyp4t8	NP_954686.2	p450	46..501	CDD:306555	119/509 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900