DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a8 and Cyp4d20

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	131/549 - (23%)
Similarity:	236/549 - (42%)	Gaps:	120/549 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ALLAILTYYIHRK---LTYFKRRGIP-----------FVAPHLIRGNMEELQKTKNIHEIFQDHY 63
            ||:.:||:...||   :..|::..||           ..|.||...|:     ...:.|.|..:.
  Fly     9 ALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENI-----IGWVGEKFDKYG 68

  Fly    64 NKFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLDGAQ 128
            ..||        |:.......:..||:..:.||  ..:....||..|......::..|....|.:
  Fly    69 KTFR--------FWILGESLIYTKDLQYFETIL--SSTTLLEKGQLYEYLRPFLNDGLLVSTGRK 123

  Fly   129 WRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPK----NSVLEIRDLVARFTVDVIGT 189
            |...|...:..|   ..|:: ...|.:.:...:||.:.:.|    .:.:::...|:...:|||..
  Fly   124 WHARRKIFTHAF---HFKVL-EHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVITE 184

  Fly   190 CAFGIQCNSLRDEKAEFLYF-GKRSLV----------DKRHGTLLNGFMRSYPKLARK-LGMVRT 242
            .|.|:|.|:..|  .:|.|. ..:|:|          .:|:..|   |..:.|.|.|: |..:|.
  Fly   185 AAMGVQVNAQND--PDFPYIKALKSVVYIQPDRMFRFSRRYNWL---FPLAAPLLHRQLLSDIRV 244

  Fly   243 APHIQEFYSRIVTETVAVREKEHIKRND----------------------FMDMLIE--LKNQKE 283
               :.:|..::::|     .:|.::|..                      .:|:|::  :.||
  Fly   245 ---MHDFTDKVISE-----RRETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQSSINNQ-- 299

  Fly   284 MTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVI-EQH 347
             .|.:.|:     .|||  ..|:|  .|.:|:||.:..|||.:|::|::|.::..|::.|: ...
  Fly   300 -PLSDADI-----REEV--DTFMF--EGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDA 354

  Fly   348 DQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAI-- 410
            ....|....:|||||:.|:.||:|||..||.:.|.|.|.          :|.|...|..:::|
  Fly   355 SAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKE----------LEIGDKTIPANTSIYL 409

  Fly   411 -----HHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIR 470
                 |.|.:.:|:|..||||||..::..|..:.|::||..||:||||.:|..::.::.::.::|
  Fly   410 VLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLR 474

  Fly   471 NFKFSTCSKTPNPLVYDPKSFVLGVKDGI 499
            .::.....:...|::    :|:|....||
  Fly   475 FYELLPLGEELKPML----NFILRSASGI 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	121/509 (24%)
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	120/516 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910