DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a8 and Cyp6g1

DIOPT Version :9

Sequence 1:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	188/521 - (36%)
Similarity:	287/521 - (55%)	Gaps:	29/521 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALTYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKN---IHEIFQDH 62
            |.||.:||.|..||:|:.|:: .|..:|::|:|||::.|..|.||.:.:.|.:|   :|  ..:.
  Fly     1 MVLTEVLFVVVAALVALYTWF-QRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMH--LSEI 62

  Fly    63 YNKFRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPIS-AHLFNLDG 126
            ||..|......||.:....|...:.|:||.|.||||||:.|.|:....:...||:. .:||.:..
  Fly    63 YNDPRLKDEAVVGIYSMNKPGLIIRDIELIKSILIKDFNRFHNRYARCDPHGDPLGYNNLFFVRD 127

  Fly   127 AQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNS---VLEIRDLVARFTVDVIG 188
            |.|:.:|.||:..|||||:|.||..:..:..:....:..:..|||   :.||:::.|:|:.|.|.
  Fly   128 AHWKGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIA 192

  Fly   189 TCAFGIQCNSLRDEKAEFLYFGKRSL---VDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFY 250
            |.||||:.|||.:..|||..:|::..   |.:.....:..|:   |||...:.:.........|.
  Fly   193 TIAFGIRANSLENPNAEFRNYGRKMFTFTVARAKDFFVAFFL---PKLVSLMRIQFFTADFSHFM 254

  Fly   251 SRIVTETVAVREKEHIKRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETS 315
            ...:...:..||:..:.|||.:|:|:.|:  ||...|..........:.::|||.|||.||||||
  Fly   255 RSTIGHVMEERERSGLLRNDLIDVLVSLR--KEAAAEPSKPHYAKNQDFLVAQAGVFFTAGFETS 317

  Fly   316 SSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLD 380
            ||||.|||||:||:|::|.::|.|:.|.:.:...:.:||..:.|:||..|:||.||:|.::|.||
  Fly   318 SSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLPFLD 382

  Fly   381 RMAAKRYVVPGHP--------NFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRP 437
            |   :...|.|.|        ::.:|.|..|.||..|:||||..:..|.:|.||||||.......
  Fly   383 R---EYESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRKNIV 444

  Fly   438 SVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYDPKSFVLGVKDGIYLK 502
            ::|:.|||.||.||||.|.|.:|:::||..|::|.....|..|...:.:|||.|||....||:|:
  Fly   445 AMAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGFVLQADGGIHLE 509

  Fly   503 V 503
            :
  Fly   510 I 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	172/481 (36%)
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	165/461 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461091
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800